Brain 18FDG-PET pattern in cognitively impaired elderly patients with bipolar disorder
Abstract Background Patients with bipolar disorder (BD) are at increased risk of dementia. The underlying mechanisms are debated. FDG-PET elucidates glucose metabolic reductions due to altered neuronal activity in the cerebral cortex, allowing detection and identification of neurodegenerative proces...
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| Format: | Article |
| Language: | English |
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SpringerOpen
2024-12-01
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| Series: | International Journal of Bipolar Disorders |
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| Online Access: | https://doi.org/10.1186/s40345-024-00366-3 |
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| author | Nouredine Saleh Capucine Blaise Amina Daoudi Matthieu Queneau Karim Fard Julien Dumurgier Esteban Munoz-Musat Emeline Marlinge Jacques Hugon Claire Hourregue Claire Paquet Emmanuel Cognat |
| author_facet | Nouredine Saleh Capucine Blaise Amina Daoudi Matthieu Queneau Karim Fard Julien Dumurgier Esteban Munoz-Musat Emeline Marlinge Jacques Hugon Claire Hourregue Claire Paquet Emmanuel Cognat |
| author_sort | Nouredine Saleh |
| collection | DOAJ |
| description | Abstract Background Patients with bipolar disorder (BD) are at increased risk of dementia. The underlying mechanisms are debated. FDG-PET elucidates glucose metabolic reductions due to altered neuronal activity in the cerebral cortex, allowing detection and identification of neurodegenerative processes. This study aims to investigate cerebral glucose metabolism in cognitively impaired elderly patients with BD using FDG-PET imaging, to elucidate potential underlying mechanisms and improve diagnostic accuracy. Methods We conducted a retrospective analysis of FDG-PET scans from 32 cognitively impaired elderly patients with BD (mean age 70.4 years). These were compared with scans from 35 non-degenerative controls (NDC) and patients diagnosed with Alzheimer’s disease (AD, n = 27), frontotemporal dementia (FTD, n = 26), and dementia with Lewy bodies (DLB, n = 18). Voxel-wise statistical analysis was performed using SPM software, adjusting for age and sex. Results No significant cortical hypometabolism was found in patients with BD compared to NDC. In contrast, typical patterns of hypometabolism were observed in the AD, FTD, and DLB groups. The findings suggest that late-life cognitive impairment in patients with BD is not due to a single common neurodegenerative process. Conclusion The absence of abnormal cortical metabolism in cognitively impaired elderly patients with BD suggests that cognitive impairment in this population may not be driven by a common neurodegenerative pathway. Further studies using other biomarkers are needed to investigate the brain processes involved, which could lead to improved understanding and management of cognitive impairment in patients with BD. |
| format | Article |
| id | doaj-art-7526397e1c57473899b7c48ecd8f31ec |
| institution | Kabale University |
| issn | 2194-7511 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | International Journal of Bipolar Disorders |
| spelling | doaj-art-7526397e1c57473899b7c48ecd8f31ec2025-01-05T12:05:19ZengSpringerOpenInternational Journal of Bipolar Disorders2194-75112024-12-011211610.1186/s40345-024-00366-3Brain 18FDG-PET pattern in cognitively impaired elderly patients with bipolar disorderNouredine Saleh0Capucine Blaise1Amina Daoudi2Matthieu Queneau3Karim Fard4Julien Dumurgier5Esteban Munoz-Musat6Emeline Marlinge7Jacques Hugon8Claire Hourregue9Claire Paquet10Emmanuel Cognat11Department of nuclear medicine, Centre de Neurologie Cognitive, GHU AP-HP.Nord, Site Lariboisière Fernand-WidalUniversité Paris Cité, UMRS 1144, INSERMUniversité Paris Cité, UMRS 1144, INSERMMolecular and functional Imaging, IMF GroupInstitut Caribéen d’imagerie nucléaire, ICIN, CHU MartiniqueCognitive Neurology Center, AP-HP.Nord, Site Lariboisière Fernand-WidalUniversité Paris Cité, UMRS 1144, INSERMDépartement de Psychiatrie, AP-HP.Nord, Site Lariboisière Fernand-WidalUniversité Paris Cité, UMRS 1144, INSERMUniversité Paris Cité, UMRS 1144, INSERMUniversité Paris Cité, UMRS 1144, INSERMUniversité Paris Cité, UMRS 1144, INSERMAbstract Background Patients with bipolar disorder (BD) are at increased risk of dementia. The underlying mechanisms are debated. FDG-PET elucidates glucose metabolic reductions due to altered neuronal activity in the cerebral cortex, allowing detection and identification of neurodegenerative processes. This study aims to investigate cerebral glucose metabolism in cognitively impaired elderly patients with BD using FDG-PET imaging, to elucidate potential underlying mechanisms and improve diagnostic accuracy. Methods We conducted a retrospective analysis of FDG-PET scans from 32 cognitively impaired elderly patients with BD (mean age 70.4 years). These were compared with scans from 35 non-degenerative controls (NDC) and patients diagnosed with Alzheimer’s disease (AD, n = 27), frontotemporal dementia (FTD, n = 26), and dementia with Lewy bodies (DLB, n = 18). Voxel-wise statistical analysis was performed using SPM software, adjusting for age and sex. Results No significant cortical hypometabolism was found in patients with BD compared to NDC. In contrast, typical patterns of hypometabolism were observed in the AD, FTD, and DLB groups. The findings suggest that late-life cognitive impairment in patients with BD is not due to a single common neurodegenerative process. Conclusion The absence of abnormal cortical metabolism in cognitively impaired elderly patients with BD suggests that cognitive impairment in this population may not be driven by a common neurodegenerative pathway. Further studies using other biomarkers are needed to investigate the brain processes involved, which could lead to improved understanding and management of cognitive impairment in patients with BD.https://doi.org/10.1186/s40345-024-00366-3Bipolar disorderElderlyNeurodegenerative disorderDementiaAlzheimer’s disease |
| spellingShingle | Nouredine Saleh Capucine Blaise Amina Daoudi Matthieu Queneau Karim Fard Julien Dumurgier Esteban Munoz-Musat Emeline Marlinge Jacques Hugon Claire Hourregue Claire Paquet Emmanuel Cognat Brain 18FDG-PET pattern in cognitively impaired elderly patients with bipolar disorder International Journal of Bipolar Disorders Bipolar disorder Elderly Neurodegenerative disorder Dementia Alzheimer’s disease |
| title | Brain 18FDG-PET pattern in cognitively impaired elderly patients with bipolar disorder |
| title_full | Brain 18FDG-PET pattern in cognitively impaired elderly patients with bipolar disorder |
| title_fullStr | Brain 18FDG-PET pattern in cognitively impaired elderly patients with bipolar disorder |
| title_full_unstemmed | Brain 18FDG-PET pattern in cognitively impaired elderly patients with bipolar disorder |
| title_short | Brain 18FDG-PET pattern in cognitively impaired elderly patients with bipolar disorder |
| title_sort | brain 18fdg pet pattern in cognitively impaired elderly patients with bipolar disorder |
| topic | Bipolar disorder Elderly Neurodegenerative disorder Dementia Alzheimer’s disease |
| url | https://doi.org/10.1186/s40345-024-00366-3 |
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