Research progress in the relationship between FOXM1 and neoplasm metabolism
FOXM1 (forkhead box M1) is an important member of the FOX transcription factor family and plays a critical role in driving the progression of multiple malignancies through its transcriptional regulatory functions. Moreover, the overexpression of FOXM1 is associated with poor prognosis in many types...
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| Format: | Article |
| Language: | zho |
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Editorial Office of Journal of Shanghai Jiao Tong University (Medical Science)
2024-10-01
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| Series: | Shanghai Jiaotong Daxue xuebao. Yixue ban |
| Subjects: | |
| Online Access: | https://xuebao.shsmu.edu.cn/CN/10.3969/j.issn.1674-8115.2024.10.015 |
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| _version_ | 1846169419780194304 |
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| author | LI Yu JIANG Yifan TONG Rongliang CHEN Diyu WU Jian |
| author_facet | LI Yu JIANG Yifan TONG Rongliang CHEN Diyu WU Jian |
| author_sort | LI Yu |
| collection | DOAJ |
| description | FOXM1 (forkhead box M1) is an important member of the FOX transcription factor family and plays a critical role in driving the progression of multiple malignancies through its transcriptional regulatory functions. Moreover, the overexpression of FOXM1 is associated with poor prognosis in many types of cancer, as it regulates a variety of biological processes such as gene expression, cell proliferation, invasion, metastasis, and apoptosis. Presently, aberrant metabolic reprogramming has been considered as the major characteristic of cancer development, determining the survival, growth, and proliferation of tumor cells. Accumulating evidence suggests that FOXM1 serves as a "bridge" between metabolism and tumorigenesis. This review aims to provide a comprehensive summary of the research progress in the relationship between FOXM1 and tumor cell metabolism, offering theoretical insights for the development of novel anti-cancer drugs targeting FOXM1. |
| format | Article |
| id | doaj-art-74ce78466e074e32b5be2ff0b2e80fee |
| institution | Kabale University |
| issn | 1674-8115 |
| language | zho |
| publishDate | 2024-10-01 |
| publisher | Editorial Office of Journal of Shanghai Jiao Tong University (Medical Science) |
| record_format | Article |
| series | Shanghai Jiaotong Daxue xuebao. Yixue ban |
| spelling | doaj-art-74ce78466e074e32b5be2ff0b2e80fee2024-11-13T03:13:33ZzhoEditorial Office of Journal of Shanghai Jiao Tong University (Medical Science)Shanghai Jiaotong Daxue xuebao. Yixue ban1674-81152024-10-0144101323132910.3969/j.issn.1674-8115.2024.10.0151674-8115（2024）10-1323-07Research progress in the relationship between FOXM1 and neoplasm metabolismLI Yu0JIANG Yifan1TONG Rongliang2CHEN Diyu3WU Jian4Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou310003, ChinaDivision of Hepatobiliary and Pancreatic Surgery, Department of Surgery, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou310003, ChinaDivision of Hepatobiliary and Pancreatic Surgery, Department of Surgery, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou310003, ChinaDivision of Hepatobiliary and Pancreatic Surgery, Department of Surgery, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou310003, ChinaDivision of Hepatobiliary and Pancreatic Surgery, Department of Surgery, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou310003, ChinaFOXM1 (forkhead box M1) is an important member of the FOX transcription factor family and plays a critical role in driving the progression of multiple malignancies through its transcriptional regulatory functions. Moreover, the overexpression of FOXM1 is associated with poor prognosis in many types of cancer, as it regulates a variety of biological processes such as gene expression, cell proliferation, invasion, metastasis, and apoptosis. Presently, aberrant metabolic reprogramming has been considered as the major characteristic of cancer development, determining the survival, growth, and proliferation of tumor cells. Accumulating evidence suggests that FOXM1 serves as a "bridge" between metabolism and tumorigenesis. This review aims to provide a comprehensive summary of the research progress in the relationship between FOXM1 and tumor cell metabolism, offering theoretical insights for the development of novel anti-cancer drugs targeting FOXM1.https://xuebao.shsmu.edu.cn/CN/10.3969/j.issn.1674-8115.2024.10.015forkhead box m1 (foxm1)tumormetabolisminhibitortumor microenvironment |
| spellingShingle | LI Yu JIANG Yifan TONG Rongliang CHEN Diyu WU Jian Research progress in the relationship between FOXM1 and neoplasm metabolism Shanghai Jiaotong Daxue xuebao. Yixue ban forkhead box m1 (foxm1) tumor metabolism inhibitor tumor microenvironment |
| title | Research progress in the relationship between FOXM1 and neoplasm metabolism |
| title_full | Research progress in the relationship between FOXM1 and neoplasm metabolism |
| title_fullStr | Research progress in the relationship between FOXM1 and neoplasm metabolism |
| title_full_unstemmed | Research progress in the relationship between FOXM1 and neoplasm metabolism |
| title_short | Research progress in the relationship between FOXM1 and neoplasm metabolism |
| title_sort | research progress in the relationship between foxm1 and neoplasm metabolism |
| topic | forkhead box m1 (foxm1) tumor metabolism inhibitor tumor microenvironment |
| url | https://xuebao.shsmu.edu.cn/CN/10.3969/j.issn.1674-8115.2024.10.015 |
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