Exploring the Therapeutical Potential of <i>Asparagopsis armata</i> Biomass: A Novel Approach for Acne Vulgaris Treatment
Acne vulgaris, a high-prevalence skin condition afflicting people, persists as a significant challenge in the absence of effective treatments and emerging antibiotic resistance. To address this pressing concern, exploration of innovative approaches is of the utmost importance. <i>Asparagopsis...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2024-10-01
|
| Series: | Marine Drugs |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1660-3397/22/11/489 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1846153075345063936 |
|---|---|
| author | Adriana P. Januário Carina Félix Rafael Félix Katie Shiels Patrick Murray Patrícia Valentão Marco F. L. Lemos |
| author_facet | Adriana P. Januário Carina Félix Rafael Félix Katie Shiels Patrick Murray Patrícia Valentão Marco F. L. Lemos |
| author_sort | Adriana P. Januário |
| collection | DOAJ |
| description | Acne vulgaris, a high-prevalence skin condition afflicting people, persists as a significant challenge in the absence of effective treatments and emerging antibiotic resistance. To address this pressing concern, exploration of innovative approaches is of the utmost importance. <i>Asparagopsis armata</i>, an invasive red seaweed renowned for its diverse array of bioactive compounds, emerges as a promising candidate. This study seeks to elucidate the potential utility of <i>A. armata</i> biomass in the treatment of acne vulgaris. Crude extracts were obtained through solid–liquid extraction, and fractions were obtained using liquid–liquid extraction. The analyzed bioactivities included antioxidant, antimicrobial, and anti-inflammatory. Also, chemical characterization was performed to identify free fatty acids and compounds through LC-MS and elements. The present findings unveil compelling attributes, including anti-<i>Cutibacterium acnes</i> activity, cytotoxic and non-cytotoxic effects, antioxidant properties, and its ability to reduce nitric oxide production with consequent anti-inflammatory potential. Additionally, chemical characterization provides insights into its mineral elements, free fatty acids, and diverse compounds. The observed antimicrobial efficacy may be linked to halogenated compounds and fatty acids. Cytoprotection appears to be associated with the presence of glycerolipids and glycosylated metabolites. Furthermore, its antioxidant activity, coupled with anti-inflammatory properties, can be attributed to phenolic compounds, such as flavonoids. This study underscores the potential of <i>A. armata</i> as a natural ingredient in skincare formulations, offering an important contribution to the ongoing battle against acne vulgaris. |
| format | Article |
| id | doaj-art-74ce303e2ad24c7ebabf68f7d98c307f |
| institution | Kabale University |
| issn | 1660-3397 |
| language | English |
| publishDate | 2024-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Marine Drugs |
| spelling | doaj-art-74ce303e2ad24c7ebabf68f7d98c307f2024-11-26T18:11:19ZengMDPI AGMarine Drugs1660-33972024-10-01221148910.3390/md22110489Exploring the Therapeutical Potential of <i>Asparagopsis armata</i> Biomass: A Novel Approach for Acne Vulgaris TreatmentAdriana P. Januário0Carina Félix1Rafael Félix2Katie Shiels3Patrick Murray4Patrícia Valentão5Marco F. L. Lemos6MARE—Marine and Environmental Sciences Centre, ARNET—Aquatic Research Network Associated Laboratory, ESTM, Instituto Politécnico de Leiria, 2520-641 Peniche, PortugalMARE—Marine and Environmental Sciences Centre, ARNET—Aquatic Research Network Associated Laboratory, ESTM, Instituto Politécnico de Leiria, 2520-641 Peniche, PortugalMARE—Marine and Environmental Sciences Centre, ARNET—Aquatic Research Network Associated Laboratory, ESTM, Instituto Politécnico de Leiria, 2520-641 Peniche, PortugalLIFE—Health and Wellbeing Biosciences Research Institute, Shannon Applied Biotechnology Centre, Technological University of the Shannon, Moylish Park, V94 E8YF Limerick, IrelandLIFE—Health and Wellbeing Biosciences Research Institute, Shannon Applied Biotechnology Centre, Technological University of the Shannon, Moylish Park, V94 E8YF Limerick, IrelandLAVQ—Associated Laboratory for Green Chemistry, REQUIMTE—Network of Chemistry and Technology, Faculdade de Farmácia, Universidade do Porto, 4050-313 Porto, PortugalMARE—Marine and Environmental Sciences Centre, ARNET—Aquatic Research Network Associated Laboratory, ESTM, Instituto Politécnico de Leiria, 2520-641 Peniche, PortugalAcne vulgaris, a high-prevalence skin condition afflicting people, persists as a significant challenge in the absence of effective treatments and emerging antibiotic resistance. To address this pressing concern, exploration of innovative approaches is of the utmost importance. <i>Asparagopsis armata</i>, an invasive red seaweed renowned for its diverse array of bioactive compounds, emerges as a promising candidate. This study seeks to elucidate the potential utility of <i>A. armata</i> biomass in the treatment of acne vulgaris. Crude extracts were obtained through solid–liquid extraction, and fractions were obtained using liquid–liquid extraction. The analyzed bioactivities included antioxidant, antimicrobial, and anti-inflammatory. Also, chemical characterization was performed to identify free fatty acids and compounds through LC-MS and elements. The present findings unveil compelling attributes, including anti-<i>Cutibacterium acnes</i> activity, cytotoxic and non-cytotoxic effects, antioxidant properties, and its ability to reduce nitric oxide production with consequent anti-inflammatory potential. Additionally, chemical characterization provides insights into its mineral elements, free fatty acids, and diverse compounds. The observed antimicrobial efficacy may be linked to halogenated compounds and fatty acids. Cytoprotection appears to be associated with the presence of glycerolipids and glycosylated metabolites. Furthermore, its antioxidant activity, coupled with anti-inflammatory properties, can be attributed to phenolic compounds, such as flavonoids. This study underscores the potential of <i>A. armata</i> as a natural ingredient in skincare formulations, offering an important contribution to the ongoing battle against acne vulgaris.https://www.mdpi.com/1660-3397/22/11/489<i>Asparagopsis armata</i>acne vulgarisbioactive compoundsfatty acidshydroethanolic extractionRhodophyta |
| spellingShingle | Adriana P. Januário Carina Félix Rafael Félix Katie Shiels Patrick Murray Patrícia Valentão Marco F. L. Lemos Exploring the Therapeutical Potential of <i>Asparagopsis armata</i> Biomass: A Novel Approach for Acne Vulgaris Treatment Marine Drugs <i>Asparagopsis armata</i> acne vulgaris bioactive compounds fatty acids hydroethanolic extraction Rhodophyta |
| title | Exploring the Therapeutical Potential of <i>Asparagopsis armata</i> Biomass: A Novel Approach for Acne Vulgaris Treatment |
| title_full | Exploring the Therapeutical Potential of <i>Asparagopsis armata</i> Biomass: A Novel Approach for Acne Vulgaris Treatment |
| title_fullStr | Exploring the Therapeutical Potential of <i>Asparagopsis armata</i> Biomass: A Novel Approach for Acne Vulgaris Treatment |
| title_full_unstemmed | Exploring the Therapeutical Potential of <i>Asparagopsis armata</i> Biomass: A Novel Approach for Acne Vulgaris Treatment |
| title_short | Exploring the Therapeutical Potential of <i>Asparagopsis armata</i> Biomass: A Novel Approach for Acne Vulgaris Treatment |
| title_sort | exploring the therapeutical potential of i asparagopsis armata i biomass a novel approach for acne vulgaris treatment |
| topic | <i>Asparagopsis armata</i> acne vulgaris bioactive compounds fatty acids hydroethanolic extraction Rhodophyta |
| url | https://www.mdpi.com/1660-3397/22/11/489 |
| work_keys_str_mv | AT adrianapjanuario exploringthetherapeuticalpotentialofiasparagopsisarmataibiomassanovelapproachforacnevulgaristreatment AT carinafelix exploringthetherapeuticalpotentialofiasparagopsisarmataibiomassanovelapproachforacnevulgaristreatment AT rafaelfelix exploringthetherapeuticalpotentialofiasparagopsisarmataibiomassanovelapproachforacnevulgaristreatment AT katieshiels exploringthetherapeuticalpotentialofiasparagopsisarmataibiomassanovelapproachforacnevulgaristreatment AT patrickmurray exploringthetherapeuticalpotentialofiasparagopsisarmataibiomassanovelapproachforacnevulgaristreatment AT patriciavalentao exploringthetherapeuticalpotentialofiasparagopsisarmataibiomassanovelapproachforacnevulgaristreatment AT marcofllemos exploringthetherapeuticalpotentialofiasparagopsisarmataibiomassanovelapproachforacnevulgaristreatment |