Estimation of salivary and serum basic fibroblast growth factor in treated and untreated patients with oral squamous cell carcinoma
Objective: The purpose of this study was to evaluate salivary and serum basic fibroblast growth factor (bFGF) level in OSCC patients to provide a reliable biomarker for the early detection, monitoring, and prognosis of OSCC patients. Materials and methods: The study enrolled 90 subjects, equally gro...
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| Format: | Article |
| Language: | English |
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Elsevier
2019-01-01
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| Series: | Journal of Oral Biology and Craniofacial Research |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2212426818302197 |
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| author | Archana Gupta Anurag Tripathi Ranjitkumar Patil Vijay Kumar Vikram Khanna Vandana Singh |
| author_facet | Archana Gupta Anurag Tripathi Ranjitkumar Patil Vijay Kumar Vikram Khanna Vandana Singh |
| author_sort | Archana Gupta |
| collection | DOAJ |
| description | Objective: The purpose of this study was to evaluate salivary and serum basic fibroblast growth factor (bFGF) level in OSCC patients to provide a reliable biomarker for the early detection, monitoring, and prognosis of OSCC patients. Materials and methods: The study enrolled 90 subjects, equally grouped as recently diagnosed & untreated OSCC patients (Group I), treated OSCC without any recurrence (Group II) & as control (Group III). Enzyme-linked immunosorbent assay was employed to measure bFGF concentrations in saliva and serum samples of all three groups. The results were tabulated and analyzed statistically. Results: Group I showed high-level of bFGF expression profile in saliva (8.80 ± 1.26 pg/ml) whereas the levels of bFGF in group II (2.69 ± 0.17 pg/ml) and Group III (3.17 ± 0.43 pg/ml) are significantly lower than group I. Serum bFGF levels were also high in group I (6.33 ± 0.81 pg/ml) and decreased significantly in group II (3.52 ± 0.45 pg/ml) however, the control group showed elevated range of levels (7.63 ± 0.88 pg/ml). Conclusions: This study demonstrates the reliability of salivary bFGF marker as diagnostic as well as prognostic marker. Serum bFGF could also be used as prognostic marker only in Oral Squamous cell carcinoma patients. |
| format | Article |
| id | doaj-art-74c98ff3f088469bb7d3f6a091994276 |
| institution | Kabale University |
| issn | 2212-4268 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Oral Biology and Craniofacial Research |
| spelling | doaj-art-74c98ff3f088469bb7d3f6a0919942762024-11-23T06:27:42ZengElsevierJournal of Oral Biology and Craniofacial Research2212-42682019-01-01911923Estimation of salivary and serum basic fibroblast growth factor in treated and untreated patients with oral squamous cell carcinomaArchana Gupta0Anurag Tripathi1Ranjitkumar Patil2Vijay Kumar3Vikram Khanna4Vandana Singh5Department of Oral Medicine & Radiology, King George's Medical University, Lucknow, UP, IndiaCorresponding author.; Department of Oral Medicine & Radiology, King George's Medical University, Lucknow, UP, IndiaDepartment of Oral Medicine & Radiology, King George's Medical University, Lucknow, UP, IndiaDepartment of Oral Medicine & Radiology, King George's Medical University, Lucknow, UP, IndiaDepartment of Oral Medicine & Radiology, King George's Medical University, Lucknow, UP, IndiaDepartment of Oral Medicine & Radiology, King George's Medical University, Lucknow, UP, IndiaObjective: The purpose of this study was to evaluate salivary and serum basic fibroblast growth factor (bFGF) level in OSCC patients to provide a reliable biomarker for the early detection, monitoring, and prognosis of OSCC patients. Materials and methods: The study enrolled 90 subjects, equally grouped as recently diagnosed & untreated OSCC patients (Group I), treated OSCC without any recurrence (Group II) & as control (Group III). Enzyme-linked immunosorbent assay was employed to measure bFGF concentrations in saliva and serum samples of all three groups. The results were tabulated and analyzed statistically. Results: Group I showed high-level of bFGF expression profile in saliva (8.80 ± 1.26 pg/ml) whereas the levels of bFGF in group II (2.69 ± 0.17 pg/ml) and Group III (3.17 ± 0.43 pg/ml) are significantly lower than group I. Serum bFGF levels were also high in group I (6.33 ± 0.81 pg/ml) and decreased significantly in group II (3.52 ± 0.45 pg/ml) however, the control group showed elevated range of levels (7.63 ± 0.88 pg/ml). Conclusions: This study demonstrates the reliability of salivary bFGF marker as diagnostic as well as prognostic marker. Serum bFGF could also be used as prognostic marker only in Oral Squamous cell carcinoma patients.http://www.sciencedirect.com/science/article/pii/S2212426818302197Oral squamous cell carcinomaBasic fibroblast growth factorSerumSalivaBiomarker |
| spellingShingle | Archana Gupta Anurag Tripathi Ranjitkumar Patil Vijay Kumar Vikram Khanna Vandana Singh Estimation of salivary and serum basic fibroblast growth factor in treated and untreated patients with oral squamous cell carcinoma Journal of Oral Biology and Craniofacial Research Oral squamous cell carcinoma Basic fibroblast growth factor Serum Saliva Biomarker |
| title | Estimation of salivary and serum basic fibroblast growth factor in treated and untreated patients with oral squamous cell carcinoma |
| title_full | Estimation of salivary and serum basic fibroblast growth factor in treated and untreated patients with oral squamous cell carcinoma |
| title_fullStr | Estimation of salivary and serum basic fibroblast growth factor in treated and untreated patients with oral squamous cell carcinoma |
| title_full_unstemmed | Estimation of salivary and serum basic fibroblast growth factor in treated and untreated patients with oral squamous cell carcinoma |
| title_short | Estimation of salivary and serum basic fibroblast growth factor in treated and untreated patients with oral squamous cell carcinoma |
| title_sort | estimation of salivary and serum basic fibroblast growth factor in treated and untreated patients with oral squamous cell carcinoma |
| topic | Oral squamous cell carcinoma Basic fibroblast growth factor Serum Saliva Biomarker |
| url | http://www.sciencedirect.com/science/article/pii/S2212426818302197 |
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