Correlation between circulating cell-free mitochondrial DNA content and severity of knee degeneration in patients with knee osteoarthritis: a cross-sectional study

Correlation between circulating cell-free mitochondrial DNA content and severity of knee degeneration in patients with knee osteoarthritis: a cross-sectional study

Abstract Background Knee osteoarthritis (KOA) is characterized by mitochondrial damage and increased inflammation. Circulating cell-free mitochondrial DNA (ccf-mtDNA), which originates from damaged mitochondria, is an endogenous damage-associated molecular pattern (DAMPs) molecule that may trigger i...

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Bibliographic Details
Main Authors:	Yan-lin Wu, Shao-gui Wan, Yi Long, Hua Ye, Jia-ming Yang, Yun Luo, Yan-biao Zhong, Li Xiao, Hai-yan Chen, Mao-yuan Wang
Format:	Article
Language:	English
Published:	BMC 2024-11-01
Series:	Arthritis Research & Therapy
Subjects:	Knee osteoarthritis Circulating cell-free mitochondrial DNA Liquid biopsy biomarker Case–control study
Online Access:	https://doi.org/10.1186/s13075-024-03438-y
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