Oxidative stress response: a critical factor affecting the ecological competitiveness of Streptococcus mutans
Oral microecological balance is closely associated with the development of dental caries. Oxidative stress is one of the important factors regulating the composition and structure of the oral microbial community. Streptococcus mutans is linked to the occurrence and development of dental caries. The...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2024-12-01
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| Series: | Journal of Oral Microbiology |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/20002297.2023.2292539 |
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| _version_ | 1846156390205227008 |
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| author | Xingqun Cheng Xin Xu Xuedong Zhou Jia Ning |
| author_facet | Xingqun Cheng Xin Xu Xuedong Zhou Jia Ning |
| author_sort | Xingqun Cheng |
| collection | DOAJ |
| description | Oral microecological balance is closely associated with the development of dental caries. Oxidative stress is one of the important factors regulating the composition and structure of the oral microbial community. Streptococcus mutans is linked to the occurrence and development of dental caries. The ability of S. mutans to withstand oxidative stress affects its survival competitiveness in biofilms. The oxidative stress regulatory mechanisms of S. mutans include synthesis of reductase, regulation of metal ions uptake, regulator PerR, transcription regulator Spx, extracellular uptake of glutathione, and other related signal transduction systems. Here, we provide an overview of how S. mutans adapts to oxidative stress and its influence on oral microecology, which may offer novel options to investigate the cariogenic mechanisms of S. mutans in the oral microenvironment, and new targets for the ecological prevention and treatment of dental caries. |
| format | Article |
| id | doaj-art-749d5e7d1d7f4ec79d61b8abfaf597df |
| institution | Kabale University |
| issn | 2000-2297 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Journal of Oral Microbiology |
| spelling | doaj-art-749d5e7d1d7f4ec79d61b8abfaf597df2024-11-26T06:52:11ZengTaylor & Francis GroupJournal of Oral Microbiology2000-22972024-12-0116110.1080/20002297.2023.2292539Oxidative stress response: a critical factor affecting the ecological competitiveness of Streptococcus mutansXingqun Cheng0Xin Xu1Xuedong Zhou2Jia Ning3State Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, ChinaState Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, ChinaState Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, ChinaDepartment of General Dentistry, School & Hospital of Stomatology, Tianjin Medical University, Tianjin, ChinaOral microecological balance is closely associated with the development of dental caries. Oxidative stress is one of the important factors regulating the composition and structure of the oral microbial community. Streptococcus mutans is linked to the occurrence and development of dental caries. The ability of S. mutans to withstand oxidative stress affects its survival competitiveness in biofilms. The oxidative stress regulatory mechanisms of S. mutans include synthesis of reductase, regulation of metal ions uptake, regulator PerR, transcription regulator Spx, extracellular uptake of glutathione, and other related signal transduction systems. Here, we provide an overview of how S. mutans adapts to oxidative stress and its influence on oral microecology, which may offer novel options to investigate the cariogenic mechanisms of S. mutans in the oral microenvironment, and new targets for the ecological prevention and treatment of dental caries.https://www.tandfonline.com/doi/10.1080/20002297.2023.2292539Streptococcus mutansoxidative stresshydrogen peroxideoral microecologydental caries |
| spellingShingle | Xingqun Cheng Xin Xu Xuedong Zhou Jia Ning Oxidative stress response: a critical factor affecting the ecological competitiveness of Streptococcus mutans Journal of Oral Microbiology Streptococcus mutans oxidative stress hydrogen peroxide oral microecology dental caries |
| title | Oxidative stress response: a critical factor affecting the ecological competitiveness of Streptococcus mutans |
| title_full | Oxidative stress response: a critical factor affecting the ecological competitiveness of Streptococcus mutans |
| title_fullStr | Oxidative stress response: a critical factor affecting the ecological competitiveness of Streptococcus mutans |
| title_full_unstemmed | Oxidative stress response: a critical factor affecting the ecological competitiveness of Streptococcus mutans |
| title_short | Oxidative stress response: a critical factor affecting the ecological competitiveness of Streptococcus mutans |
| title_sort | oxidative stress response a critical factor affecting the ecological competitiveness of streptococcus mutans |
| topic | Streptococcus mutans oxidative stress hydrogen peroxide oral microecology dental caries |
| url | https://www.tandfonline.com/doi/10.1080/20002297.2023.2292539 |
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