Whole blood transcriptome profile identifies motor neurone disease RNA biomarker signatures

Blood-based biomarkers for motor neuron disease are needed for better diagnosis, progression prediction, and clinical trial monitoring. We used whole blood-derived total RNA and performed whole transcriptome analysis to compare the gene expression profiles in (motor neurone disease) MND patients to...

Full description

Saved in:

Bibliographic Details
Main Authors:	Sulev Kõks, Karin Rallmann, Mari Muldmaa, Jack Price, Abigail L. Pfaff, Pille Taba
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-01-01
Series:	Experimental Biology and Medicine
Subjects:	motor neuron disease amyotrophic lateral sclerosis RNA-seq whole transcriptome gene expression profiling
Online Access:	https://www.ebm-journal.org/articles/10.3389/ebm.2024.10401/full
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Whole transcriptome analysis of unmutated sporadic ALS patients' peripheral blood reveals phenotype-specific gene expression signature
by: Francesca Dragoni, et al.
Published: (2025-03-01)

Evaluation of a biomarker for amyotrophic lateral sclerosis derived from a hypomethylated DNA signature of human motor neurons
by: Calum Harvey, et al.
Published: (2025-01-01)

Evaluation of Dysphagia in Amyotrophic Lateral Sclerosis
by: Xiao QIU, et al.
Published: (2017-02-01)

Staging model for amyotrophic lateral sclerosis in Singapore
by: Yuan Teck Tay, et al.
Published: (2022-07-01)

Hypothalamic atrophy in primary lateral sclerosis, assessed by convolutional neural network-based automatic segmentation
by: Jan Kassubek, et al.
Published: (2025-01-01)

Associations of cachexia and frailty with amyotrophic lateral sclerosis
by: Tracy L. Peters, et al.
Published: (2025-02-01)

Polysomnographic titration of non-invasive ventilation in motor neurone disease (3TLA): study protocol for a randomised controlled trial
by: David J. Berlowitz, et al.
Published: (2025-01-01)

Analyzing the potential of neuronal pentraxin 2 as a biomarker in neurological disorders: A literature review
by: Ubaid Ansari, et al.
Published: (2024-12-01)

Shared prognostic information in amyotrophic lateral sclerosis – systematic assessment of the patients’ perception of neurofilament light chain and the ALS functional rating scale
by: Lukas Maximilian Möhwald, et al.
Published: (2025-02-01)

Optineurin overexpression ameliorates neurodegeneration through regulating neuroinflammation and mitochondrial quality in a murine model of amyotrophic lateral sclerosis
by: Shumin Zhao, et al.
Published: (2025-02-01)

Associations of Abnormal Sleep Duration and Chronotype with Higher Risk of Incident Amyotrophic Lateral Sclerosis: A UK Biobank Prospective Cohort Study
by: Gan Zhang, et al.
Published: (2024-12-01)

Rasch-Built Overall Amyotrophic Lateral Sclerosis Disability Scale as a Novel Tool to Measure Disease Progression
by: Can Sun, et al.
Published: (2025-01-01)

Multifocal motor neuropathy. A clinical case and literature review
by: O. Laucius, et al.
Published: (2023-10-01)

Prognostic Value of Cerebrospinal Fluid and Serum Neurofilament Light Chain in Amyotrophic Lateral Sclerosis: A Correlation Study
by: Siqi Dong, et al.
Published: (2025-01-01)

Integrative transcriptome profiling for identifying ALS potential treatment using the drug repurposing approach
by: Navid Kashani, et al.
Published: (2025-01-01)

Application of antisense oligonucleotide drugs in amyotrophic lateral sclerosis and Huntington’s disease
by: Kaili Ou, et al.
Published: (2025-01-01)

Metabolic rate and insulin-independent glucose uptake increase in a TDP-43Q331K mouse model of amyotrophic lateral sclerosis
by: Tanya S. McDonald, et al.
Published: (2025-02-01)

The use of the Strengths and Difficulties Questionnaire to assess mental health in adolescents with parents diagnosed with Amyotrophic Lateral Sclerosis
by: Stefan Nilsson, et al.
Published: (2025-12-01)

Homozygous mice with mutant protein FUS[1-359] overexpression: Innovative possibilities for ALS treatment
by: Nikita S. Zhunusov
Published: (2024-12-01)

Examining vaccination-related adverse events in frequent neurodegenerative diseases
by: Shabnam Sodagari, et al.
Published: (2025-02-01)

Genetic Insights Into the Role of Cathepsins in Alzheimer's Disease, Parkinson's Disease, and Amyotrophic Lateral Sclerosis: Evidence From Mendelian Randomization Study
by: Yanhong Jiang, et al.
Published: (2025-01-01)

Cortical thickness correlated with peripheral inflammatory cytokines in amyotrophic lateral sclerosis
by: Jing Yang, et al.
Published: (2025-01-01)

Decremental response in patients with amyotrophic lateral sclerosis during repetitive nerve stimulation and its relationships with impaired homeostasis
by: Jinghong Zhang, et al.
Published: (2025-01-01)

Tandem repeat expansions and copy number variations as risk factors and diagnostic tools for amyotrophic lateral sclerosis
by: Eleonora Sabetta, et al.
Published: (2025-02-01)

Deciphering the spectrum of astrocyte diversity: Insights into molecular, morphological, and functional dimensions in health and neurodegenerative diseases
by: Fumito Endo
Published: (2025-01-01)

Association of smoking with amyotrophic lateral sclerosis: A systematic review, and meta-analysis, including dose-response analysis
by: Kihun Kim<sup>+<sup/>, et al.
Published: (2024-01-01)

Host genetics and gut microbiota influence lipid metabolism and inflammation: potential implications for ALS pathophysiology in SOD1G93A mice
by: Elena Niccolai, et al.
Published: (2024-11-01)

Ten years preceding a diagnosis of neurodegenerative disease in Europe and Australia: medication use, health conditions, and biomarkers associated with Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosisResearch in context
by: Dang Wei, et al.
Published: (2025-03-01)

Frequency of orthostatic hypotension in the Pooled Resource Open-Access ALS Clinical Trials database
by: C. Quarracino, et al.
Published: (2025-01-01)

Epigenetic Mechanisms Underlying Sex Differences in Neurodegenerative Diseases
by: Andrea Stoccoro
Published: (2025-01-01)

A single-center, single-arm, prospective, open-label, and comparative trial to evaluate the safety and tolerability profile of a 90-day oral L-arginine hydrochloride intervention for patients with amyotrophic lateral sclerosis
by: Hiroyuki Naito, et al.
Published: (2025-01-01)

Calcium Signalling in Neurological Disorders, with Insights from Miniature Fluorescence Microscopy
by: Dechuan Sun, et al.
Published: (2024-12-01)

Data Report: Educational pathway addressing food and nutrition in amyotrophic lateral sclerosis on the AVASUS platform
by: Karla M. D. Coutinho, et al.
Published: (2025-01-01)

Gain-of-function ANXA11 mutation cause late-onset ALS with aberrant protein aggregation, neuroinflammation and autophagy impairment
by: Qing Liu, et al.
Published: (2025-01-01)

Direct and Indirect Protein Interactions Link FUS Aggregation to Histone Post-Translational Modification Dysregulation and Growth Suppression in an ALS/FTD Yeast Model
by: Seth A. Bennett, et al.
Published: (2025-01-01)

Daily Assistance for Amyotrophic Lateral Sclerosis Patients Based on a Wearable Multimodal Brain-Computer Interface Mouse
by: Ya Jiang, et al.
Published: (2025-01-01)

Sporadic ALS hiPSC-derived motor neurons show axonal defects linked to altered axon guidance pathways
by: Lisha Ye, et al.
Published: (2025-03-01)

Artificial intelligence empowered voice generation for amyotrophic lateral sclerosis patients
by: Stefano Regondi, et al.
Published: (2025-01-01)

Amyotrofik Lateral Skleroz Tanılı Bir Hastanın Henderson Hemşirelik Modeli’ne Göre Değerlendirilmesi: Olgu Sunumu
by: Gülşen Kılıç, et al.
Published: (2019-12-01)

Multi-functional role of apolipoprotein E in neurodegenerative diseases
by: Sadequl Islam, et al.
Published: (2025-01-01)