Expression of serum miR‐135a in patients with allergic rhinitis and its relationship with Treg/Th17 balance
Abstract The dysregulation of microRNA (miRNA) expression contributes to the development of allergic rhinitis (AR). This study investigates serum miR‐135a levels and their association with regulatory T cell (Treg) and T helper cell 17 (Th17) balance in AR patients. A total of 93 AR patients and 76 h...
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| Format: | Article |
| Language: | English |
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Wiley
2025-01-01
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| Series: | Kaohsiung Journal of Medical Sciences |
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| Online Access: | https://doi.org/10.1002/kjm2.12918 |
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| author | Jing Cai Fang Wang Sheng‐Liu Shi |
| author_facet | Jing Cai Fang Wang Sheng‐Liu Shi |
| author_sort | Jing Cai |
| collection | DOAJ |
| description | Abstract The dysregulation of microRNA (miRNA) expression contributes to the development of allergic rhinitis (AR). This study investigates serum miR‐135a levels and their association with regulatory T cell (Treg) and T helper cell 17 (Th17) balance in AR patients. A total of 93 AR patients and 76 healthy controls were retrospectively recruited. Levels of serum miR‐135a, peripheral blood Th17 and Treg cells, and Treg/Th17‐related cytokines were measured. We assessed the diagnostic value of serum miR‐135a for AR and its relationship with Treg/Th17 balance. AR patients showed significantly elevated immunoglobulin E (IgE), peripheral blood Th17 cells, and IL‐17 and IL‐6 levels, alongside reduced serum miR‐135a, Treg cells, IL‐10, TGF‐β1, and Treg/Th17 ratios. A serum miR‐135a of ≤0.536 demonstrated diagnostic potential for AR. Patients with higher serum miR‐135a levels displayed increased Treg cell level and Treg/Th17 ratios, reduced Th17 cell, and lower total nasal symptom score (TNSS). Serum miR‐135a levels in AR patients negatively correlated with TNSS, IL‐17, IL‐6, and Th17 cell percentages, and positively correlated with IL‐10, TGF‐β1, Treg cell percentages, and Treg/Th17 ratios. Collectively, decreased serum miR‐135a levels in AR patients are associated with Treg/Th17 balance, supporting miR‐135a as a potential biomarker for AR diagnosis. |
| format | Article |
| id | doaj-art-748781107c91427893049c8d406bc2d1 |
| institution | Kabale University |
| issn | 1607-551X 2410-8650 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Kaohsiung Journal of Medical Sciences |
| spelling | doaj-art-748781107c91427893049c8d406bc2d12025-01-11T05:35:55ZengWileyKaohsiung Journal of Medical Sciences1607-551X2410-86502025-01-01411n/an/a10.1002/kjm2.12918Expression of serum miR‐135a in patients with allergic rhinitis and its relationship with Treg/Th17 balanceJing Cai0Fang Wang1Sheng‐Liu Shi2Department of Octolaryngology First Affiliated Hospital of Kunming Medical University Kunming People's Republic of ChinaDepartment of Octolaryngology First Affiliated Hospital of Kunming Medical University Kunming People's Republic of ChinaDepartment of Rehabilitation Medicine First Affiliated Hospital of Kunming Medical University Kunming People's Republic of ChinaAbstract The dysregulation of microRNA (miRNA) expression contributes to the development of allergic rhinitis (AR). This study investigates serum miR‐135a levels and their association with regulatory T cell (Treg) and T helper cell 17 (Th17) balance in AR patients. A total of 93 AR patients and 76 healthy controls were retrospectively recruited. Levels of serum miR‐135a, peripheral blood Th17 and Treg cells, and Treg/Th17‐related cytokines were measured. We assessed the diagnostic value of serum miR‐135a for AR and its relationship with Treg/Th17 balance. AR patients showed significantly elevated immunoglobulin E (IgE), peripheral blood Th17 cells, and IL‐17 and IL‐6 levels, alongside reduced serum miR‐135a, Treg cells, IL‐10, TGF‐β1, and Treg/Th17 ratios. A serum miR‐135a of ≤0.536 demonstrated diagnostic potential for AR. Patients with higher serum miR‐135a levels displayed increased Treg cell level and Treg/Th17 ratios, reduced Th17 cell, and lower total nasal symptom score (TNSS). Serum miR‐135a levels in AR patients negatively correlated with TNSS, IL‐17, IL‐6, and Th17 cell percentages, and positively correlated with IL‐10, TGF‐β1, Treg cell percentages, and Treg/Th17 ratios. Collectively, decreased serum miR‐135a levels in AR patients are associated with Treg/Th17 balance, supporting miR‐135a as a potential biomarker for AR diagnosis.https://doi.org/10.1002/kjm2.12918allergic rhinitiscell balancemicroRNAmicroRNA‐135aregulatory T cell/T helper cell 17 |
| spellingShingle | Jing Cai Fang Wang Sheng‐Liu Shi Expression of serum miR‐135a in patients with allergic rhinitis and its relationship with Treg/Th17 balance Kaohsiung Journal of Medical Sciences allergic rhinitis cell balance microRNA microRNA‐135a regulatory T cell/T helper cell 17 |
| title | Expression of serum miR‐135a in patients with allergic rhinitis and its relationship with Treg/Th17 balance |
| title_full | Expression of serum miR‐135a in patients with allergic rhinitis and its relationship with Treg/Th17 balance |
| title_fullStr | Expression of serum miR‐135a in patients with allergic rhinitis and its relationship with Treg/Th17 balance |
| title_full_unstemmed | Expression of serum miR‐135a in patients with allergic rhinitis and its relationship with Treg/Th17 balance |
| title_short | Expression of serum miR‐135a in patients with allergic rhinitis and its relationship with Treg/Th17 balance |
| title_sort | expression of serum mir 135a in patients with allergic rhinitis and its relationship with treg th17 balance |
| topic | allergic rhinitis cell balance microRNA microRNA‐135a regulatory T cell/T helper cell 17 |
| url | https://doi.org/10.1002/kjm2.12918 |
| work_keys_str_mv | AT jingcai expressionofserummir135ainpatientswithallergicrhinitisanditsrelationshipwithtregth17balance AT fangwang expressionofserummir135ainpatientswithallergicrhinitisanditsrelationshipwithtregth17balance AT shengliushi expressionofserummir135ainpatientswithallergicrhinitisanditsrelationshipwithtregth17balance |