Passive hyperthermia alters the resting-state functional connectivity of mouse brain
Purpose To investigate how passive hyperthermia affect the resting-state functional brain activity based on an acute mouse model after heat stress exposure.Materials and methods Twenty-eight rs-fMRI data of C57BL/6J male mice which weighing about 24 ∼ 29 g and aged 12 ∼ 16 weeks were collected. The...
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| Format: | Article |
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Taylor & Francis Group
2024-12-01
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| Series: | International Journal of Hyperthermia |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/02656736.2024.2376678 |
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| author | Yang Ruan Kai Liu Bo Li Shaowen Qian Hongxia Lei Yao Xing Gang Sun |
| author_facet | Yang Ruan Kai Liu Bo Li Shaowen Qian Hongxia Lei Yao Xing Gang Sun |
| author_sort | Yang Ruan |
| collection | DOAJ |
| description | Purpose To investigate how passive hyperthermia affect the resting-state functional brain activity based on an acute mouse model after heat stress exposure.Materials and methods Twenty-eight rs-fMRI data of C57BL/6J male mice which weighing about 24 ∼ 29 g and aged 12 ∼ 16 weeks were collected. The mice in the hyperthermia group (HT, 40 °C ± 0.5 °C, 40 min) were subjected to passive hyperthermia before the anesthesia preparation for scanning. While the normal control group (NC) was subjected to normothermia condition (NC, 20 °C ± 2 °C, 40 min). After data preprocessing, we performed independent component analysis (ICA) and region of interested (ROI)-ROI functional connectivity (FC) analyses on the data of both HT (n = 13) and NC (n = 15).Results The group ICA analysis showed that the HT and the NC both included 11 intrinsic connectivity networks (ICNs), and can be divided into four types of networks: the cortical network (CN), the subcortical network (SN), the default mode network (DMN), and cerebellar networks. CN and SN belongs to sensorimotor network. Compared with NC, the functional network organization of ICNs in the HT was altered and the overall functional intensity was decreased. Furthermore, 13 ROIs were selected in CN, SN, and DMN for further ROI-ROI FC analysis. The ROI-ROI FC analysis showed that passive hyperthermia exposure significantly reduced the FC strength in the overall brain represented by CN, SN, DMN of mice.Conclusion Prolonged exposure to high temperature has a greater impact on the overall perception and cognitive level of mice, which might help understand the relationship between neuronal activities and physiological thermal sensation and regulation as well as behavioral changes. |
| format | Article |
| id | doaj-art-746a67bb911c4bf2b7063052dfacc5bd |
| institution | Kabale University |
| issn | 0265-6736 1464-5157 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | International Journal of Hyperthermia |
| spelling | doaj-art-746a67bb911c4bf2b7063052dfacc5bd2025-01-03T09:30:27ZengTaylor & Francis GroupInternational Journal of Hyperthermia0265-67361464-51572024-12-0141110.1080/02656736.2024.2376678Passive hyperthermia alters the resting-state functional connectivity of mouse brainYang Ruan0Kai Liu1Bo Li2Shaowen Qian3Hongxia Lei4Yao Xing5Gang Sun6Wuhan United Imaging Life Science Instruments Ltd., Wuhan, Hubei, PR China960th Hosp Joint Logist Support Force PLA, Dept Radiology, Jinan, Shandong, PR China960th Hosp Joint Logist Support Force PLA, Dept Radiology, Jinan, Shandong, PR China960th Hosp Joint Logist Support Force PLA, Dept Radiology, Jinan, Shandong, PR ChinaWuhan United Imaging Life Science Instruments Ltd., Wuhan, Hubei, PR ChinaWuhan United Imaging Life Science Instruments Ltd., Wuhan, Hubei, PR China960th Hosp Joint Logist Support Force PLA, Dept Radiology, Jinan, Shandong, PR ChinaPurpose To investigate how passive hyperthermia affect the resting-state functional brain activity based on an acute mouse model after heat stress exposure.Materials and methods Twenty-eight rs-fMRI data of C57BL/6J male mice which weighing about 24 ∼ 29 g and aged 12 ∼ 16 weeks were collected. The mice in the hyperthermia group (HT, 40 °C ± 0.5 °C, 40 min) were subjected to passive hyperthermia before the anesthesia preparation for scanning. While the normal control group (NC) was subjected to normothermia condition (NC, 20 °C ± 2 °C, 40 min). After data preprocessing, we performed independent component analysis (ICA) and region of interested (ROI)-ROI functional connectivity (FC) analyses on the data of both HT (n = 13) and NC (n = 15).Results The group ICA analysis showed that the HT and the NC both included 11 intrinsic connectivity networks (ICNs), and can be divided into four types of networks: the cortical network (CN), the subcortical network (SN), the default mode network (DMN), and cerebellar networks. CN and SN belongs to sensorimotor network. Compared with NC, the functional network organization of ICNs in the HT was altered and the overall functional intensity was decreased. Furthermore, 13 ROIs were selected in CN, SN, and DMN for further ROI-ROI FC analysis. The ROI-ROI FC analysis showed that passive hyperthermia exposure significantly reduced the FC strength in the overall brain represented by CN, SN, DMN of mice.Conclusion Prolonged exposure to high temperature has a greater impact on the overall perception and cognitive level of mice, which might help understand the relationship between neuronal activities and physiological thermal sensation and regulation as well as behavioral changes.https://www.tandfonline.com/doi/10.1080/02656736.2024.2376678Passive hyperthermiaresting stateblood oxygenation level-dependentfunctional connectivityICAmouse |
| spellingShingle | Yang Ruan Kai Liu Bo Li Shaowen Qian Hongxia Lei Yao Xing Gang Sun Passive hyperthermia alters the resting-state functional connectivity of mouse brain International Journal of Hyperthermia Passive hyperthermia resting state blood oxygenation level-dependent functional connectivity ICA mouse |
| title | Passive hyperthermia alters the resting-state functional connectivity of mouse brain |
| title_full | Passive hyperthermia alters the resting-state functional connectivity of mouse brain |
| title_fullStr | Passive hyperthermia alters the resting-state functional connectivity of mouse brain |
| title_full_unstemmed | Passive hyperthermia alters the resting-state functional connectivity of mouse brain |
| title_short | Passive hyperthermia alters the resting-state functional connectivity of mouse brain |
| title_sort | passive hyperthermia alters the resting state functional connectivity of mouse brain |
| topic | Passive hyperthermia resting state blood oxygenation level-dependent functional connectivity ICA mouse |
| url | https://www.tandfonline.com/doi/10.1080/02656736.2024.2376678 |
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