Hand acceleration time (HAT) as a diagnostic tool in the assessment of haemodialysis access-induced distal ischaemia (HAIDI): study protocol for a prospective cohort study in the Barcelona south metropolitan area
Introduction Chronic hand ischaemia may affect some haemodialysis patients with an arteriovenous fistula (AVF) or graft (AVG), a condition known as haemodialysis access-induced distal ischaemia (HAIDI). Duplex ultrasonography (DUS) can provide comprehensive insights into anatomical and perfusion pro...
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BMJ Publishing Group
2025-01-01
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| Series: | BMJ Open |
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| author | Sebastian Videla Begoña Gonzalo Emma Espinar Siloé Palacios Carolina Herranz Elena Iborra Ortega |
| author_facet | Sebastian Videla Begoña Gonzalo Emma Espinar Siloé Palacios Carolina Herranz Elena Iborra Ortega |
| author_sort | Sebastian Videla |
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| description | Introduction Chronic hand ischaemia may affect some haemodialysis patients with an arteriovenous fistula (AVF) or graft (AVG), a condition known as haemodialysis access-induced distal ischaemia (HAIDI). Duplex ultrasonography (DUS) can provide comprehensive insights into anatomical and perfusion properties, and measuring the hand acceleration time (HAT) has been demonstrated to be sensitive within the framework of chronic upper limb ischaemia.Methods and analysis This single-centre, prospective cohort study will involve adult end-stage renal disease (ESRD) patients requiring either AVF or AVG for haemodialysis. The primary outcome will be HAT values (measured at the radial, ulnar and four hand arteries) before and after surgery. Secondary outcomes will include the incidence of HAIDI, vascular access patency, and the incidence of complications. A sample size of 126 subjects will be required to estimate HAIDI incidence with a 95% CI and ±5% precision. Statistical analyses will involve paired t-tests to compare preoperative and postoperative HAT values and determine optimal HAT cut-off values for diagnosing HAIDI.Ethics and dissemination This study was approved by the Bellvitge University Hospital Institutional Review Board (PR 201/23). Written informed consent will be obtained from all study participants before any study-related procedure is performed. Results will be published in peer-reviewed journals.Trial registration number ClinicalTrial.gov: NCT06187207. Pre Results. |
| format | Article |
| id | doaj-art-745e2603e4bf42a9a1e65eb075a2c63c |
| institution | Kabale University |
| issn | 2044-6055 |
| language | English |
| publishDate | 2025-01-01 |
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| spelling | doaj-art-745e2603e4bf42a9a1e65eb075a2c63c2025-01-06T18:35:12ZengBMJ Publishing GroupBMJ Open2044-60552025-01-0115110.1136/bmjopen-2024-093911Hand acceleration time (HAT) as a diagnostic tool in the assessment of haemodialysis access-induced distal ischaemia (HAIDI): study protocol for a prospective cohort study in the Barcelona south metropolitan areaSebastian Videla0Begoña Gonzalo1Emma Espinar2Siloé Palacios3Carolina Herranz4Elena Iborra Ortega53 Clinical Pharmacology Department, Hospital Germans Trias i Pujol, Badalona, Catalunya, Spain1 Angiology, Vascular and Endovascular Surgery Department, Bellvitge University Hospital, Carrer de la Feixa Llarga, s/n, 08907 – L’Hospitalet de Llobregat, Barcelona, Spain1 Angiology, Vascular and Endovascular Surgery Department, Bellvitge University Hospital, Carrer de la Feixa Llarga, s/n, 08907 – L’Hospitalet de Llobregat, Barcelona, Spain1 Angiology, Vascular and Endovascular Surgery Department, Bellvitge University Hospital, Carrer de la Feixa Llarga, s/n, 08907 – L’Hospitalet de Llobregat, Barcelona, Spain1 Angiology, Vascular and Endovascular Surgery Department, Bellvitge University Hospital, Carrer de la Feixa Llarga, s/n, 08907 – L’Hospitalet de Llobregat, Barcelona, Spain2 Bio Heart Cardiovascular Diseases Research Group, Bellvitge Institute for Biomedical Research, L`Hospitalet de Llobregat, Barcelona, SpainIntroduction Chronic hand ischaemia may affect some haemodialysis patients with an arteriovenous fistula (AVF) or graft (AVG), a condition known as haemodialysis access-induced distal ischaemia (HAIDI). Duplex ultrasonography (DUS) can provide comprehensive insights into anatomical and perfusion properties, and measuring the hand acceleration time (HAT) has been demonstrated to be sensitive within the framework of chronic upper limb ischaemia.Methods and analysis This single-centre, prospective cohort study will involve adult end-stage renal disease (ESRD) patients requiring either AVF or AVG for haemodialysis. The primary outcome will be HAT values (measured at the radial, ulnar and four hand arteries) before and after surgery. Secondary outcomes will include the incidence of HAIDI, vascular access patency, and the incidence of complications. A sample size of 126 subjects will be required to estimate HAIDI incidence with a 95% CI and ±5% precision. Statistical analyses will involve paired t-tests to compare preoperative and postoperative HAT values and determine optimal HAT cut-off values for diagnosing HAIDI.Ethics and dissemination This study was approved by the Bellvitge University Hospital Institutional Review Board (PR 201/23). Written informed consent will be obtained from all study participants before any study-related procedure is performed. Results will be published in peer-reviewed journals.Trial registration number ClinicalTrial.gov: NCT06187207. Pre Results.https://bmjopen.bmj.com/content/15/1/e093911.full |
| spellingShingle | Sebastian Videla Begoña Gonzalo Emma Espinar Siloé Palacios Carolina Herranz Elena Iborra Ortega Hand acceleration time (HAT) as a diagnostic tool in the assessment of haemodialysis access-induced distal ischaemia (HAIDI): study protocol for a prospective cohort study in the Barcelona south metropolitan area BMJ Open |
| title | Hand acceleration time (HAT) as a diagnostic tool in the assessment of haemodialysis access-induced distal ischaemia (HAIDI): study protocol for a prospective cohort study in the Barcelona south metropolitan area |
| title_full | Hand acceleration time (HAT) as a diagnostic tool in the assessment of haemodialysis access-induced distal ischaemia (HAIDI): study protocol for a prospective cohort study in the Barcelona south metropolitan area |
| title_fullStr | Hand acceleration time (HAT) as a diagnostic tool in the assessment of haemodialysis access-induced distal ischaemia (HAIDI): study protocol for a prospective cohort study in the Barcelona south metropolitan area |
| title_full_unstemmed | Hand acceleration time (HAT) as a diagnostic tool in the assessment of haemodialysis access-induced distal ischaemia (HAIDI): study protocol for a prospective cohort study in the Barcelona south metropolitan area |
| title_short | Hand acceleration time (HAT) as a diagnostic tool in the assessment of haemodialysis access-induced distal ischaemia (HAIDI): study protocol for a prospective cohort study in the Barcelona south metropolitan area |
| title_sort | hand acceleration time hat as a diagnostic tool in the assessment of haemodialysis access induced distal ischaemia haidi study protocol for a prospective cohort study in the barcelona south metropolitan area |
| url | https://bmjopen.bmj.com/content/15/1/e093911.full |
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