Nuclear pore and nucleocytoplasmic transport impairment in oxidative stress-induced neurodegeneration: relevance to molecular mechanisms in Pathogenesis of Parkinson’s and other related neurodegenerative diseases

Nuclear pore and nucleocytoplasmic transport impairment in oxidative stress-induced neurodegeneration: relevance to molecular mechanisms in Pathogenesis of Parkinson’s and other related neurodegenerative diseases

Abstract Nuclear pore complexes (NPCs) are embedded in the nuclear envelope and facilitate the exchange of macromolecules between the nucleus and cytoplasm in eukaryotic cells. The dysfunction of the NPC and nuclear transport plays a significant role in aging and the pathogenesis of various neurodeg...

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Bibliographic Details
Main Authors: Zainab Riaz, Gabriel S. Richardson, Huajun Jin, Gary Zenitsky, Vellareddy Anantharam, Arthi Kanthasamy, Anumantha G. Kanthasamy
Format: Article
Language:English
Published: BMC 2024-11-01
Series:Molecular Neurodegeneration
Subjects:
Parkinson’s disease
Nuclear pore complex
Nucleocytoplasmic transport
Oxidative stress
Alpha-synuclein
Neurodegeneration
Online Access:https://doi.org/10.1186/s13024-024-00774-0
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