High-intensity interval training modulates thrombotic susceptibility in metabolic syndrome: Attenuation of plasma PAI-1 and fibrinogen via ameliorated metabolic dysfunction
Metabolic syndrome (MetS) elevates thrombotic risk through dysregulated coagulation factors, including plasminogen activator inhibitor-1 (PAI-1) and fibrinogen, driven by visceral adiposity and metabolic dysfunction. High-intensity interval training (HIIT) improves cardiometabolic health, but its ef...
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| Format: | Article |
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2025-03-01
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| Series: | Journal of Exercise & Organ Cross Talk |
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| Online Access: | https://www.jeoct.com/article_222673_9b2b8057d2e5235b446f426bf74cb79c.pdf |
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| author | Niyousha Ghazbani Arezoo Razmdideh Amin Alimohammadi Danial Bagherzadeh Ehsan Rezaee Moeini Mohammad Reza Mozaffari Mohammad Sadra Roshani Koosha |
| author_facet | Niyousha Ghazbani Arezoo Razmdideh Amin Alimohammadi Danial Bagherzadeh Ehsan Rezaee Moeini Mohammad Reza Mozaffari Mohammad Sadra Roshani Koosha |
| author_sort | Niyousha Ghazbani |
| collection | DOAJ |
| description | Metabolic syndrome (MetS) elevates thrombotic risk through dysregulated coagulation factors, including plasminogen activator inhibitor-1 (PAI-1) and fibrinogen, driven by visceral adiposity and metabolic dysfunction. High-intensity interval training (HIIT) improves cardiometabolic health, but its effects on hemostatic markers in MetS remain underexplored. Twenty-four men with MetS (ATP-III criteria; age 44.4 ± 5.4 years, BMI 31.7 ± 2.3 kg·m⁻²) were randomized to HIIT (n=12) or control (n=12). HIIT comprised 3 sessions/week for 8 weeks (4 × 4-min intervals at 90% HRmax, interspersed with 3-min active recovery at 70% HRmax). Fasting plasma PAI-1, fibrinogen, insulin resistance (HOMA-IR), body composition, and lipid profiles were assessed pre/post-intervention. HIIT significantly reduced PAI-1 (−30.7%, p<0.001) and fibrinogen (−21.8%, p<0.001) versus controls. Concurrent improvements occurred in HOMA-IR (−20.6%, p<0.001), body fat (−3.8%, p<0.05), systolic/diastolic BP (−7.5%/−5.2%, p<0.05), LDL-c (−5.6%), triglycerides (−9.4%), and HDL-c (+3.0%; all p<0.05). Control group exhibited no significant changes. HIIT attenuates prothrombotic risk in MetS, evidenced by reductions in PAI-1 and fibrinogen. These hemostatic improvements are mechanistically linked to ameliorated metabolic dysfunction, highlighting HIIT’s role in modulating adipose tissue–vascular cross talk. |
| format | Article |
| id | doaj-art-73eef8e07b454c5a839c4b313a6eb44e |
| institution | Kabale University |
| issn | 2783-2074 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | JEOCT publisher |
| record_format | Article |
| series | Journal of Exercise & Organ Cross Talk |
| spelling | doaj-art-73eef8e07b454c5a839c4b313a6eb44e2025-08-20T03:58:44ZengJEOCT publisherJournal of Exercise & Organ Cross Talk2783-20742025-03-0151192510.22122/jeoct.2025.528002.1158222673High-intensity interval training modulates thrombotic susceptibility in metabolic syndrome: Attenuation of plasma PAI-1 and fibrinogen via ameliorated metabolic dysfunctionNiyousha Ghazbani0Arezoo Razmdideh1Amin Alimohammadi2Danial Bagherzadeh3Ehsan Rezaee Moeini4Mohammad Reza Mozaffari5Mohammad Sadra Roshani Koosha6Department of Physical Education and Sport Sciences, Science and Research Branch, Islamic Azad University, Tehran, Iran.Department of Physical Education and Sport Sciences, Faculty of Literature, Humanities and Social Sciences, Science and Research Branch, Islamic Azad University, Tehran, Iran.Department of Physical Education and Sport Sciences, Science and Research Branch, Islamic Azad University, Tehran, Iran.Department of Physical Education and Sport Sciences, Science and Research Branch, Islamic Azad University, Tehran, Iran.Department of Exercise Physiology, Sport Sciences Research Institute, Tehran, Iran.Department of Exercise Physiology, University of Tehran, Tehran, Iran.Department of Physical Education, Islamic Azad University, Tehran, Iran.Metabolic syndrome (MetS) elevates thrombotic risk through dysregulated coagulation factors, including plasminogen activator inhibitor-1 (PAI-1) and fibrinogen, driven by visceral adiposity and metabolic dysfunction. High-intensity interval training (HIIT) improves cardiometabolic health, but its effects on hemostatic markers in MetS remain underexplored. Twenty-four men with MetS (ATP-III criteria; age 44.4 ± 5.4 years, BMI 31.7 ± 2.3 kg·m⁻²) were randomized to HIIT (n=12) or control (n=12). HIIT comprised 3 sessions/week for 8 weeks (4 × 4-min intervals at 90% HRmax, interspersed with 3-min active recovery at 70% HRmax). Fasting plasma PAI-1, fibrinogen, insulin resistance (HOMA-IR), body composition, and lipid profiles were assessed pre/post-intervention. HIIT significantly reduced PAI-1 (−30.7%, p<0.001) and fibrinogen (−21.8%, p<0.001) versus controls. Concurrent improvements occurred in HOMA-IR (−20.6%, p<0.001), body fat (−3.8%, p<0.05), systolic/diastolic BP (−7.5%/−5.2%, p<0.05), LDL-c (−5.6%), triglycerides (−9.4%), and HDL-c (+3.0%; all p<0.05). Control group exhibited no significant changes. HIIT attenuates prothrombotic risk in MetS, evidenced by reductions in PAI-1 and fibrinogen. These hemostatic improvements are mechanistically linked to ameliorated metabolic dysfunction, highlighting HIIT’s role in modulating adipose tissue–vascular cross talk.https://www.jeoct.com/article_222673_9b2b8057d2e5235b446f426bf74cb79c.pdfhigh-intensity interval trainingmetabolic syndromepai-1fibrinogenthrombotic riskhemostasisinsulin resistancevisceral adiposityexercise prescription |
| spellingShingle | Niyousha Ghazbani Arezoo Razmdideh Amin Alimohammadi Danial Bagherzadeh Ehsan Rezaee Moeini Mohammad Reza Mozaffari Mohammad Sadra Roshani Koosha High-intensity interval training modulates thrombotic susceptibility in metabolic syndrome: Attenuation of plasma PAI-1 and fibrinogen via ameliorated metabolic dysfunction Journal of Exercise & Organ Cross Talk high-intensity interval training metabolic syndrome pai-1 fibrinogen thrombotic risk hemostasis insulin resistance visceral adiposity exercise prescription |
| title | High-intensity interval training modulates thrombotic susceptibility in metabolic syndrome: Attenuation of plasma PAI-1 and fibrinogen via ameliorated metabolic dysfunction |
| title_full | High-intensity interval training modulates thrombotic susceptibility in metabolic syndrome: Attenuation of plasma PAI-1 and fibrinogen via ameliorated metabolic dysfunction |
| title_fullStr | High-intensity interval training modulates thrombotic susceptibility in metabolic syndrome: Attenuation of plasma PAI-1 and fibrinogen via ameliorated metabolic dysfunction |
| title_full_unstemmed | High-intensity interval training modulates thrombotic susceptibility in metabolic syndrome: Attenuation of plasma PAI-1 and fibrinogen via ameliorated metabolic dysfunction |
| title_short | High-intensity interval training modulates thrombotic susceptibility in metabolic syndrome: Attenuation of plasma PAI-1 and fibrinogen via ameliorated metabolic dysfunction |
| title_sort | high intensity interval training modulates thrombotic susceptibility in metabolic syndrome attenuation of plasma pai 1 and fibrinogen via ameliorated metabolic dysfunction |
| topic | high-intensity interval training metabolic syndrome pai-1 fibrinogen thrombotic risk hemostasis insulin resistance visceral adiposity exercise prescription |
| url | https://www.jeoct.com/article_222673_9b2b8057d2e5235b446f426bf74cb79c.pdf |
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