The impact of solute carrier proteins on disrupting substance regulation in metabolic disorders: insights and clinical applications
Carbohydrates, lipids, bile acids, various inorganic salt ions and organic acids are the main nutrients or indispensable components of the human body. Dysregulation in the processes of absorption, transport, metabolism, and excretion of these metabolites can lead to the onset of severe metabolic dis...
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2024.1510080/full |
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| author | Jiangxia Du Minhui Shen Jiajia Chen Hao Yan Zhifei Xu Xiaochun Yang Bo Yang Bo Yang Peihua Luo Peihua Luo Kefeng Ding Yuhuai Hu Qiaojun He Qiaojun He Qiaojun He Qiaojun He |
| author_facet | Jiangxia Du Minhui Shen Jiajia Chen Hao Yan Zhifei Xu Xiaochun Yang Bo Yang Bo Yang Peihua Luo Peihua Luo Kefeng Ding Yuhuai Hu Qiaojun He Qiaojun He Qiaojun He Qiaojun He |
| author_sort | Jiangxia Du |
| collection | DOAJ |
| description | Carbohydrates, lipids, bile acids, various inorganic salt ions and organic acids are the main nutrients or indispensable components of the human body. Dysregulation in the processes of absorption, transport, metabolism, and excretion of these metabolites can lead to the onset of severe metabolic disorders, such as type 2 diabetes, non-alcoholic fatty liver disease, gout and hyperbilirubinemia. As the second largest membrane receptor supergroup, several major families in the solute carrier (SLC) supergroup have been found to play key roles in the transport of substances such as carbohydrates, lipids, urate, bile acids, monocarboxylates and zinc ions. Based on common metabolic dysregulation and related metabolic substances, we explored the relationship between several major families of SLC supergroup and metabolic diseases, providing examples of drugs targeting SLC proteins that have been approved or are currently in clinical/preclinical research as well as SLC-related diagnostic techniques that are in clinical use or under investigation. By highlighting these connections, we aim to provide insights that may contribute to the development of improved treatment strategies and targeted therapies for metabolic disorders. |
| format | Article |
| id | doaj-art-73ec83140c7c43b59ca11353e1633e68 |
| institution | Kabale University |
| issn | 1663-9812 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj-art-73ec83140c7c43b59ca11353e1633e682025-01-09T06:10:13ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122025-01-011510.3389/fphar.2024.15100801510080The impact of solute carrier proteins on disrupting substance regulation in metabolic disorders: insights and clinical applicationsJiangxia Du0Minhui Shen1Jiajia Chen2Hao Yan3Zhifei Xu4Xiaochun Yang5Bo Yang6Bo Yang7Peihua Luo8Peihua Luo9Kefeng Ding10Yuhuai Hu11Qiaojun He12Qiaojun He13Qiaojun He14Qiaojun He15Center for Medical Research and Innovation in Digestive System Tumors, Ministry of Education, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, ChinaCenter for Drug Safety Evaluation and Research of Zhejiang University, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, Zhejiang, ChinaCenter for Drug Safety Evaluation and Research of Zhejiang University, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, Zhejiang, ChinaCenter for Drug Safety Evaluation and Research of Zhejiang University, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, Zhejiang, ChinaCenter for Drug Safety Evaluation and Research of Zhejiang University, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, Zhejiang, ChinaCenter for Drug Safety Evaluation and Research of Zhejiang University, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, Zhejiang, ChinaInstitute of Pharmacology and Toxicology, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, Zhejiang, ChinaSchool of Medicine, Hangzhou City University, Hangzhou, Zhejiang, ChinaCenter for Drug Safety Evaluation and Research of Zhejiang University, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, Zhejiang, ChinaDepartment of Pharmaceutical and Translational Toxicology, Innovation Institute for Artificial Intelligence in Medicine of Zhejiang University, Hangzhou, Zhejiang, ChinaCenter for Medical Research and Innovation in Digestive System Tumors, Ministry of Education, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, ChinaYuhong Pharmaceutical Technology Co., Ltd., Hangzhou, Zhejiang, ChinaCenter for Medical Research and Innovation in Digestive System Tumors, Ministry of Education, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, ChinaCenter for Drug Safety Evaluation and Research of Zhejiang University, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, Zhejiang, ChinaSchool of Medicine, Hangzhou City University, Hangzhou, Zhejiang, ChinaDepartment of Pharmaceutical and Translational Toxicology, Innovation Institute for Artificial Intelligence in Medicine of Zhejiang University, Hangzhou, Zhejiang, ChinaCarbohydrates, lipids, bile acids, various inorganic salt ions and organic acids are the main nutrients or indispensable components of the human body. Dysregulation in the processes of absorption, transport, metabolism, and excretion of these metabolites can lead to the onset of severe metabolic disorders, such as type 2 diabetes, non-alcoholic fatty liver disease, gout and hyperbilirubinemia. As the second largest membrane receptor supergroup, several major families in the solute carrier (SLC) supergroup have been found to play key roles in the transport of substances such as carbohydrates, lipids, urate, bile acids, monocarboxylates and zinc ions. Based on common metabolic dysregulation and related metabolic substances, we explored the relationship between several major families of SLC supergroup and metabolic diseases, providing examples of drugs targeting SLC proteins that have been approved or are currently in clinical/preclinical research as well as SLC-related diagnostic techniques that are in clinical use or under investigation. By highlighting these connections, we aim to provide insights that may contribute to the development of improved treatment strategies and targeted therapies for metabolic disorders.https://www.frontiersin.org/articles/10.3389/fphar.2024.1510080/fullsolute carriermetabolic diseasetransport substratetransport dysregulationtherapeutic targets |
| spellingShingle | Jiangxia Du Minhui Shen Jiajia Chen Hao Yan Zhifei Xu Xiaochun Yang Bo Yang Bo Yang Peihua Luo Peihua Luo Kefeng Ding Yuhuai Hu Qiaojun He Qiaojun He Qiaojun He Qiaojun He The impact of solute carrier proteins on disrupting substance regulation in metabolic disorders: insights and clinical applications Frontiers in Pharmacology solute carrier metabolic disease transport substrate transport dysregulation therapeutic targets |
| title | The impact of solute carrier proteins on disrupting substance regulation in metabolic disorders: insights and clinical applications |
| title_full | The impact of solute carrier proteins on disrupting substance regulation in metabolic disorders: insights and clinical applications |
| title_fullStr | The impact of solute carrier proteins on disrupting substance regulation in metabolic disorders: insights and clinical applications |
| title_full_unstemmed | The impact of solute carrier proteins on disrupting substance regulation in metabolic disorders: insights and clinical applications |
| title_short | The impact of solute carrier proteins on disrupting substance regulation in metabolic disorders: insights and clinical applications |
| title_sort | impact of solute carrier proteins on disrupting substance regulation in metabolic disorders insights and clinical applications |
| topic | solute carrier metabolic disease transport substrate transport dysregulation therapeutic targets |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2024.1510080/full |
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