The Role of Bone-Derived Osteocalcin in Testicular Steroidogenesis: Contributing Factor to Male Fertility

Osteocalcin (OCN), a protein predominantly produced by osteoblasts in bone, has emerged as a significant factor in bone metabolism and reproductive function. This article reviews the latest research on the role of OCN beyond its traditional functions in bone mineralisation, particularly its influenc...

Full description

Saved in:
Bibliographic Details
Main Authors: Izatus Shima Taib, Putri Ayu Jayusman
Format: Article
Language:English
Published: MDPI AG 2024-12-01
Series:Diseases
Subjects:
Online Access:https://www.mdpi.com/2079-9721/12/12/335
Tags: Add Tag
No Tags, Be the first to tag this record!
_version_ 1846104997368954880
author Izatus Shima Taib
Putri Ayu Jayusman
author_facet Izatus Shima Taib
Putri Ayu Jayusman
author_sort Izatus Shima Taib
collection DOAJ
description Osteocalcin (OCN), a protein predominantly produced by osteoblasts in bone, has emerged as a significant factor in bone metabolism and reproductive function. This article reviews the latest research on the role of OCN beyond its traditional functions in bone mineralisation, particularly its influence on testicular steroidogenesis and male fertility. The structure and modifications of OCN are elaborated upon, highlighting its uncarboxylated form (ucOCN), which is becoming increasingly recognised for its bioactive properties. The impact of OCN on bone quantity, quality and strength is summarised, emphasising its role as a regulator of bone metabolism. Furthermore, the influence of ucOCN on testicular steroidogenesis and the involvement of GPRC6A, a G protein-coupled receptor, in mediating these effects are also explored. Evidence suggests that ucOCN regulates testosterone synthesis and spermatogenesis, which indirectly have the potential to influence bone metabolism integrity. In conclusion, OCN, particularly in its uncarboxylated form, plays a crucial role in bone metabolism and male fertility by regulating testicular steroidogenesis, with GPRC6A mediating these effects, thereby linking bone health and reproductive functions.
format Article
id doaj-art-73dba5b4f6fd479e9eb40b227e0bebd5
institution Kabale University
issn 2079-9721
language English
publishDate 2024-12-01
publisher MDPI AG
record_format Article
series Diseases
spelling doaj-art-73dba5b4f6fd479e9eb40b227e0bebd52024-12-27T14:21:23ZengMDPI AGDiseases2079-97212024-12-01121233510.3390/diseases12120335The Role of Bone-Derived Osteocalcin in Testicular Steroidogenesis: Contributing Factor to Male FertilityIzatus Shima Taib0Putri Ayu Jayusman1Centre of Diagnostics, Therapeutics and Investigative Studies, Faculty of Health Sciences, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, Kuala Lumpur 50300, MalaysiaDepartment of Craniofacial Diagnostics and Biosciences, Faculty of Dentistry, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, Kuala Lumpur 50300, MalaysiaOsteocalcin (OCN), a protein predominantly produced by osteoblasts in bone, has emerged as a significant factor in bone metabolism and reproductive function. This article reviews the latest research on the role of OCN beyond its traditional functions in bone mineralisation, particularly its influence on testicular steroidogenesis and male fertility. The structure and modifications of OCN are elaborated upon, highlighting its uncarboxylated form (ucOCN), which is becoming increasingly recognised for its bioactive properties. The impact of OCN on bone quantity, quality and strength is summarised, emphasising its role as a regulator of bone metabolism. Furthermore, the influence of ucOCN on testicular steroidogenesis and the involvement of GPRC6A, a G protein-coupled receptor, in mediating these effects are also explored. Evidence suggests that ucOCN regulates testosterone synthesis and spermatogenesis, which indirectly have the potential to influence bone metabolism integrity. In conclusion, OCN, particularly in its uncarboxylated form, plays a crucial role in bone metabolism and male fertility by regulating testicular steroidogenesis, with GPRC6A mediating these effects, thereby linking bone health and reproductive functions.https://www.mdpi.com/2079-9721/12/12/335uncarboxylated osteocalcinosteoblasttestosteronetesticular steroidogenesis
spellingShingle Izatus Shima Taib
Putri Ayu Jayusman
The Role of Bone-Derived Osteocalcin in Testicular Steroidogenesis: Contributing Factor to Male Fertility
Diseases
uncarboxylated osteocalcin
osteoblast
testosterone
testicular steroidogenesis
title The Role of Bone-Derived Osteocalcin in Testicular Steroidogenesis: Contributing Factor to Male Fertility
title_full The Role of Bone-Derived Osteocalcin in Testicular Steroidogenesis: Contributing Factor to Male Fertility
title_fullStr The Role of Bone-Derived Osteocalcin in Testicular Steroidogenesis: Contributing Factor to Male Fertility
title_full_unstemmed The Role of Bone-Derived Osteocalcin in Testicular Steroidogenesis: Contributing Factor to Male Fertility
title_short The Role of Bone-Derived Osteocalcin in Testicular Steroidogenesis: Contributing Factor to Male Fertility
title_sort role of bone derived osteocalcin in testicular steroidogenesis contributing factor to male fertility
topic uncarboxylated osteocalcin
osteoblast
testosterone
testicular steroidogenesis
url https://www.mdpi.com/2079-9721/12/12/335
work_keys_str_mv AT izatusshimataib theroleofbonederivedosteocalcinintesticularsteroidogenesiscontributingfactortomalefertility
AT putriayujayusman theroleofbonederivedosteocalcinintesticularsteroidogenesiscontributingfactortomalefertility
AT izatusshimataib roleofbonederivedosteocalcinintesticularsteroidogenesiscontributingfactortomalefertility
AT putriayujayusman roleofbonederivedosteocalcinintesticularsteroidogenesiscontributingfactortomalefertility