Prodromal Parkinson’s disease and subsequent risk of Parkinson’s disease and mortality
Abstract Association of prodromal Parkinson’s disease (PD) with risk of PD and risk of mortality in individuals with PD warrant investigation through large-scale prospective study. We included 501,475 participants without PD at baseline. Eight prodromal features were measured. Incident PD cases were...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2025-01-01
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| Series: | npj Parkinson's Disease |
| Online Access: | https://doi.org/10.1038/s41531-024-00863-3 |
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| author | Xiao Chen Yaqi Li Yun Shen Michael A. Schwarzschild Xiang Gao |
| author_facet | Xiao Chen Yaqi Li Yun Shen Michael A. Schwarzschild Xiang Gao |
| author_sort | Xiao Chen |
| collection | DOAJ |
| description | Abstract Association of prodromal Parkinson’s disease (PD) with risk of PD and risk of mortality in individuals with PD warrant investigation through large-scale prospective study. We included 501,475 participants without PD at baseline. Eight prodromal features were measured. Incident PD cases were identified via hospital admission, death register, and self-report. Cox regression models were used to compute hazard ratios (HRs) and 95% confidence intervals (CIs). Multivariable-adjusted HRs3+vs.0 prodromal PD features and 95%CIs were 3.12 (2.58–3.78) for men and 2.71 (2.11–3.47) for women. Prodromal PD predicted only PD onset occurred during the first 6 years of follow-up (HR3+vs.0 prodromal features = 10.5; 95% CI: 8.60–12.9), but not after 6 years (HR = 1.00; 95%CI: 0.76-1.32). The presence of prodromal PD conferred a higher risk of mortality among participants with PD. Having prodromal PD were associated with higher probability of developing PD in short-term and higher risk of mortality among individuals with PD. |
| format | Article |
| id | doaj-art-73d530fdcee9470184c17e0683aebf37 |
| institution | Kabale University |
| issn | 2373-8057 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Nature Portfolio |
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| series | npj Parkinson's Disease |
| spelling | doaj-art-73d530fdcee9470184c17e0683aebf372025-01-12T12:12:37ZengNature Portfolionpj Parkinson's Disease2373-80572025-01-011111810.1038/s41531-024-00863-3Prodromal Parkinson’s disease and subsequent risk of Parkinson’s disease and mortalityXiao Chen0Yaqi Li1Yun Shen2Michael A. Schwarzschild3Xiang Gao4Department of Nutrition and Food Hygiene, School of Public Health, Institute of Nutrition, Zhongshan Hospital, Fudan UniversityDepartment of Nutrition and Food Hygiene, School of Public Health, Institute of Nutrition, Zhongshan Hospital, Fudan UniversityDepartment of Neurology, The Second Affiliated Hospital of Soochow UniversityMolecular Neurobiology Laboratory, MassGeneral Institute for Neurodegenerative Disease, Department of Neurology, Massachusetts General HospitalDepartment of Nutrition and Food Hygiene, School of Public Health, Institute of Nutrition, Zhongshan Hospital, Fudan UniversityAbstract Association of prodromal Parkinson’s disease (PD) with risk of PD and risk of mortality in individuals with PD warrant investigation through large-scale prospective study. We included 501,475 participants without PD at baseline. Eight prodromal features were measured. Incident PD cases were identified via hospital admission, death register, and self-report. Cox regression models were used to compute hazard ratios (HRs) and 95% confidence intervals (CIs). Multivariable-adjusted HRs3+vs.0 prodromal PD features and 95%CIs were 3.12 (2.58–3.78) for men and 2.71 (2.11–3.47) for women. Prodromal PD predicted only PD onset occurred during the first 6 years of follow-up (HR3+vs.0 prodromal features = 10.5; 95% CI: 8.60–12.9), but not after 6 years (HR = 1.00; 95%CI: 0.76-1.32). The presence of prodromal PD conferred a higher risk of mortality among participants with PD. Having prodromal PD were associated with higher probability of developing PD in short-term and higher risk of mortality among individuals with PD.https://doi.org/10.1038/s41531-024-00863-3 |
| spellingShingle | Xiao Chen Yaqi Li Yun Shen Michael A. Schwarzschild Xiang Gao Prodromal Parkinson’s disease and subsequent risk of Parkinson’s disease and mortality npj Parkinson's Disease |
| title | Prodromal Parkinson’s disease and subsequent risk of Parkinson’s disease and mortality |
| title_full | Prodromal Parkinson’s disease and subsequent risk of Parkinson’s disease and mortality |
| title_fullStr | Prodromal Parkinson’s disease and subsequent risk of Parkinson’s disease and mortality |
| title_full_unstemmed | Prodromal Parkinson’s disease and subsequent risk of Parkinson’s disease and mortality |
| title_short | Prodromal Parkinson’s disease and subsequent risk of Parkinson’s disease and mortality |
| title_sort | prodromal parkinson s disease and subsequent risk of parkinson s disease and mortality |
| url | https://doi.org/10.1038/s41531-024-00863-3 |
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