Exploring the efficacy and constraints of platinum nanoparticles as adjuvant therapy in silicosis management
Silicosis represents a formidable occupational lung pathology precipitated by the pulmonary assimilation of respirable crystalline silica particulates. This condition engenders a cascade of cellular oxidative stress via the activation of bioavailable silica, culminating in the generation of reactive...
Saved in:
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2025-12-01
|
| Series: | Drug Delivery |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/10717544.2024.2445257 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1841543408747806720 |
|---|---|
| author | Ge Ban Yuanjie Chen Yingbing Liang Xiaona Wang Dan Ding Rui Liu Jingjing Jia Ran Zhao Chenxia Wang Na Li |
| author_facet | Ge Ban Yuanjie Chen Yingbing Liang Xiaona Wang Dan Ding Rui Liu Jingjing Jia Ran Zhao Chenxia Wang Na Li |
| author_sort | Ge Ban |
| collection | DOAJ |
| description | Silicosis represents a formidable occupational lung pathology precipitated by the pulmonary assimilation of respirable crystalline silica particulates. This condition engenders a cascade of cellular oxidative stress via the activation of bioavailable silica, culminating in the generation of reactive oxygen species (ROS). Such oxidative mechanisms lead to irrevocable pulmonary impairment. Contemporary scholarly examinations have underscored the substantial antioxidative efficacy of platinum nanoparticles (PtNPs), postulating their utility as an adjunct therapeutic modality in silicosis management. The physicochemical interaction between PtNPs and silica demonstrates a propensity for adsorption, thereby facilitating the amelioration and subsequent pulmonary clearance of silica aggregates. In addition to their detoxifying attributes, PtNPs exhibit pronounced anti-inflammatory and antioxidative activities, which can neutralize ROS and inhibit macrophage-mediated inflammatory processes. Such attributes are instrumental in attenuating inflammatory responses and forestalling subsequent lung tissue damage. This discourse delineates the interplay between ROS and PtNPs, the pathogenesis of silicosis and its progression to pulmonary fibrosis, and critically evaluates the potential adjunct role of PtNPs in the therapeutic landscape of silicosis, alongside a contemplation of the inherent limitations associated with PtNPs application in this context. |
| format | Article |
| id | doaj-art-73868e2ecdc6446eb3b3ec6db4bbf096 |
| institution | Kabale University |
| issn | 1071-7544 1521-0464 |
| language | English |
| publishDate | 2025-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Drug Delivery |
| spelling | doaj-art-73868e2ecdc6446eb3b3ec6db4bbf0962025-01-13T12:34:30ZengTaylor & Francis GroupDrug Delivery1071-75441521-04642025-12-0132110.1080/10717544.2024.2445257Exploring the efficacy and constraints of platinum nanoparticles as adjuvant therapy in silicosis managementGe Ban0Yuanjie Chen1Yingbing Liang2Xiaona Wang3Dan Ding4Rui Liu5Jingjing Jia6Ran Zhao7Chenxia Wang8Na Li9School of Intelligent Medical Engineering, Sanquan College of Xinxiang Medical University, Xinxiang, ChinaSchool of Intelligent Medical Engineering, Sanquan College of Xinxiang Medical University, Xinxiang, ChinaDepartment of Chemistry and Biotechnology, Graduate School of Engineering Tottori University, Tottori, JapanSchool of Intelligent Medical Engineering, Sanquan College of Xinxiang Medical University, Xinxiang, ChinaSchool of Intelligent Medical Engineering, Sanquan College of Xinxiang Medical University, Xinxiang, ChinaSchool of Life Sciences and Biotechnology, Sanquan College of Xinxiang Medical University, ChinaSchool of Intelligent Medical Engineering, Sanquan College of Xinxiang Medical University, Xinxiang, ChinaSchool of Intelligent Medical Engineering, Sanquan College of Xinxiang Medical University, Xinxiang, ChinaDepartment of Respiratory Medicine, People’s Hospital of Huojia County, Xinxiang, ChinaCollege of Pharmacy, Xinxiang Medical University, Xinxiang, ChinaSilicosis represents a formidable occupational lung pathology precipitated by the pulmonary assimilation of respirable crystalline silica particulates. This condition engenders a cascade of cellular oxidative stress via the activation of bioavailable silica, culminating in the generation of reactive oxygen species (ROS). Such oxidative mechanisms lead to irrevocable pulmonary impairment. Contemporary scholarly examinations have underscored the substantial antioxidative efficacy of platinum nanoparticles (PtNPs), postulating their utility as an adjunct therapeutic modality in silicosis management. The physicochemical interaction between PtNPs and silica demonstrates a propensity for adsorption, thereby facilitating the amelioration and subsequent pulmonary clearance of silica aggregates. In addition to their detoxifying attributes, PtNPs exhibit pronounced anti-inflammatory and antioxidative activities, which can neutralize ROS and inhibit macrophage-mediated inflammatory processes. Such attributes are instrumental in attenuating inflammatory responses and forestalling subsequent lung tissue damage. This discourse delineates the interplay between ROS and PtNPs, the pathogenesis of silicosis and its progression to pulmonary fibrosis, and critically evaluates the potential adjunct role of PtNPs in the therapeutic landscape of silicosis, alongside a contemplation of the inherent limitations associated with PtNPs application in this context.https://www.tandfonline.com/doi/10.1080/10717544.2024.2445257Silicosisplatinum nanoparticles(PtNPs)reactive oxygen species(ROS)pulmonary fibrosis |
| spellingShingle | Ge Ban Yuanjie Chen Yingbing Liang Xiaona Wang Dan Ding Rui Liu Jingjing Jia Ran Zhao Chenxia Wang Na Li Exploring the efficacy and constraints of platinum nanoparticles as adjuvant therapy in silicosis management Drug Delivery Silicosis platinum nanoparticles(PtNPs) reactive oxygen species(ROS) pulmonary fibrosis |
| title | Exploring the efficacy and constraints of platinum nanoparticles as adjuvant therapy in silicosis management |
| title_full | Exploring the efficacy and constraints of platinum nanoparticles as adjuvant therapy in silicosis management |
| title_fullStr | Exploring the efficacy and constraints of platinum nanoparticles as adjuvant therapy in silicosis management |
| title_full_unstemmed | Exploring the efficacy and constraints of platinum nanoparticles as adjuvant therapy in silicosis management |
| title_short | Exploring the efficacy and constraints of platinum nanoparticles as adjuvant therapy in silicosis management |
| title_sort | exploring the efficacy and constraints of platinum nanoparticles as adjuvant therapy in silicosis management |
| topic | Silicosis platinum nanoparticles(PtNPs) reactive oxygen species(ROS) pulmonary fibrosis |
| url | https://www.tandfonline.com/doi/10.1080/10717544.2024.2445257 |
| work_keys_str_mv | AT geban exploringtheefficacyandconstraintsofplatinumnanoparticlesasadjuvanttherapyinsilicosismanagement AT yuanjiechen exploringtheefficacyandconstraintsofplatinumnanoparticlesasadjuvanttherapyinsilicosismanagement AT yingbingliang exploringtheefficacyandconstraintsofplatinumnanoparticlesasadjuvanttherapyinsilicosismanagement AT xiaonawang exploringtheefficacyandconstraintsofplatinumnanoparticlesasadjuvanttherapyinsilicosismanagement AT danding exploringtheefficacyandconstraintsofplatinumnanoparticlesasadjuvanttherapyinsilicosismanagement AT ruiliu exploringtheefficacyandconstraintsofplatinumnanoparticlesasadjuvanttherapyinsilicosismanagement AT jingjingjia exploringtheefficacyandconstraintsofplatinumnanoparticlesasadjuvanttherapyinsilicosismanagement AT ranzhao exploringtheefficacyandconstraintsofplatinumnanoparticlesasadjuvanttherapyinsilicosismanagement AT chenxiawang exploringtheefficacyandconstraintsofplatinumnanoparticlesasadjuvanttherapyinsilicosismanagement AT nali exploringtheefficacyandconstraintsofplatinumnanoparticlesasadjuvanttherapyinsilicosismanagement |