Novel environmental and sustainable approach for concurrent assay of antineoplastics in VMP regimen with a comprehensive Pharmacokinetic study

Novel environmental and sustainable approach for concurrent assay of antineoplastics in VMP regimen with a comprehensive Pharmacokinetic study

Abstract Multiple myeloma (MM) is a blood cancer that, unfortunately, has a high morbidity and mortality rate. The VMP regimen, which includes bortezomib (BOR), melphalan (MEL), and prednisolone (PRD), is a safe and effective salvage regimen for refractory or relapsed MM. Up to now, there is no esta...

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Bibliographic Details
Main Authors: Marco M. Z. Sharkawi, Noha H. Amin, Norhan R. Mohamed, Shimaa S. Zaki, Loah R. Hemeda
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Scientific Reports
Subjects:
Bortezomib
Melphalan
Prednisolone
LC-MS/MS method
Green chemistry
Pharmacokinetics
Online Access:https://doi.org/10.1038/s41598-025-15078-6
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