Shenlian Decoction Ameliorates LPS-Related Inflammation in db/db Mice: Coupling Network Pharmacology With Experimental Verification
Conclusions: This research investigated the multigene pharmacological mechanism of SL decoction against T2DM using network pharmacology and in vivo experiments. SL decoction treatment of T2DM may reverse inflammation by inhibiting LPS-related pathway activation and improving intestinal function.
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| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2025-01-01
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| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/jdr/3823051 |
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| _version_ | 1841542617116966912 |
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| author | Yi-fan Liu Yuan-yuan Liu Yao Xiao Wei-jun Huang Rui-xi Sun Jie Hu Xiao-zhe Fu Chu-xiao Tian Qiang Fu Jin-xi Zhao |
| author_facet | Yi-fan Liu Yuan-yuan Liu Yao Xiao Wei-jun Huang Rui-xi Sun Jie Hu Xiao-zhe Fu Chu-xiao Tian Qiang Fu Jin-xi Zhao |
| author_sort | Yi-fan Liu |
| collection | DOAJ |
| description | Conclusions: This research investigated the multigene pharmacological mechanism of SL decoction against T2DM using network pharmacology and in vivo experiments. SL decoction treatment of T2DM may reverse inflammation by inhibiting LPS-related pathway activation and improving intestinal function. |
| format | Article |
| id | doaj-art-735f3c6d98664d2daf6f345361a05116 |
| institution | Kabale University |
| issn | 2314-6753 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj-art-735f3c6d98664d2daf6f345361a051162025-01-14T00:00:05ZengWileyJournal of Diabetes Research2314-67532025-01-01202510.1155/jdr/3823051Shenlian Decoction Ameliorates LPS-Related Inflammation in db/db Mice: Coupling Network Pharmacology With Experimental VerificationYi-fan Liu0Yuan-yuan Liu1Yao Xiao2Wei-jun Huang3Rui-xi Sun4Jie Hu5Xiao-zhe Fu6Chu-xiao Tian7Qiang Fu8Jin-xi Zhao9Section II of Endocrinology & Nephropathy DepartmentInstitute of Chinese Medical Literature and CultureNephropathy DepartmentKey Laboratory of Chinese Internal Medicine of Ministry of Education and BeijingInstitute of Basic TheorySection II of Endocrinology & Nephropathy DepartmentSection II of Endocrinology & Nephropathy DepartmentSection II of Endocrinology & Nephropathy DepartmentSection II of Endocrinology & Nephropathy DepartmentSection II of Endocrinology & Nephropathy DepartmentConclusions: This research investigated the multigene pharmacological mechanism of SL decoction against T2DM using network pharmacology and in vivo experiments. SL decoction treatment of T2DM may reverse inflammation by inhibiting LPS-related pathway activation and improving intestinal function.http://dx.doi.org/10.1155/jdr/3823051 |
| spellingShingle | Yi-fan Liu Yuan-yuan Liu Yao Xiao Wei-jun Huang Rui-xi Sun Jie Hu Xiao-zhe Fu Chu-xiao Tian Qiang Fu Jin-xi Zhao Shenlian Decoction Ameliorates LPS-Related Inflammation in db/db Mice: Coupling Network Pharmacology With Experimental Verification Journal of Diabetes Research |
| title | Shenlian Decoction Ameliorates LPS-Related Inflammation in db/db Mice: Coupling Network Pharmacology With Experimental Verification |
| title_full | Shenlian Decoction Ameliorates LPS-Related Inflammation in db/db Mice: Coupling Network Pharmacology With Experimental Verification |
| title_fullStr | Shenlian Decoction Ameliorates LPS-Related Inflammation in db/db Mice: Coupling Network Pharmacology With Experimental Verification |
| title_full_unstemmed | Shenlian Decoction Ameliorates LPS-Related Inflammation in db/db Mice: Coupling Network Pharmacology With Experimental Verification |
| title_short | Shenlian Decoction Ameliorates LPS-Related Inflammation in db/db Mice: Coupling Network Pharmacology With Experimental Verification |
| title_sort | shenlian decoction ameliorates lps related inflammation in db db mice coupling network pharmacology with experimental verification |
| url | http://dx.doi.org/10.1155/jdr/3823051 |
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