Clonal GZMK+CD8+ T cells are identified as a hallmark of the pathogenesis of cGVHD-induced bronchiolitis obliterans syndrome after allogeneic hematopoietic stem cell transplantationResearch in context

Clonal GZMK+CD8+ T cells are identified as a hallmark of the pathogenesis of cGVHD-induced bronchiolitis obliterans syndrome after allogeneic hematopoietic stem cell transplantationResearch in context

Summary: Background: Bronchiolitis obliterans syndrome (BOS) is one of the most devastating outcomes of chronic graft-versus-host disease (cGVHD) after allogeneic hematopoietic stem cell transplantation (allo-HSCT). This remains an area of unmet clinical need for optimal therapy for BOS patients pa...

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Main Authors: Yang Gao, Ruixiang Liu, Jiawei Shi, Wei Shan, Hongyu Zhou, Zhi Chen, Xiaoyan Yue, Jie Zhang, Yi Luo, Wenjue Pan, Xiujie Zhao, Xun Zeng, Weiwei Yin, Haowen Xiao
Format: Article
Language:English
Published: Elsevier 2025-02-01
Series:EBioMedicine
Subjects:
Allogeneic hematopoietic stem cell transplantation
Chronic graft-versus-host disease
Bronchiolitis obliterans syndrome
Granzyme K
Bosutinib
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396424005711
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