A nomogram for predicting neonatal acute respiratory distress syndrome in patients with neonatal pneumonia after 34 weeks of gestation
ObjectiveTo establish a prediction nomogram for early prediction of neonatal acute respiratory distress syndrome (NARDS).MethodsThis is a retrospective cross-sectional study conducted between January 2021 and December 2023. Clinical characteristics and laboratory results of cases with neonatal pneum...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2025-01-01
|
| Series: | Frontiers in Pediatrics |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fped.2024.1451466/full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1841553895847886848 |
|---|---|
| author | Aosong Yu Huanhuan Hou Huanhuan Hou Lingyi Ran Xiaojia Sun Wanchun Xin Tong Feng |
| author_facet | Aosong Yu Huanhuan Hou Huanhuan Hou Lingyi Ran Xiaojia Sun Wanchun Xin Tong Feng |
| author_sort | Aosong Yu |
| collection | DOAJ |
| description | ObjectiveTo establish a prediction nomogram for early prediction of neonatal acute respiratory distress syndrome (NARDS).MethodsThis is a retrospective cross-sectional study conducted between January 2021 and December 2023. Clinical characteristics and laboratory results of cases with neonatal pneumonia were compared in terms of presence of NARDS diagnosis based on the Montreux Definition. The NARDS group and non-NARDS group were then compared to establish a prediction nomogram for early prediction of NARDS. The predictive accuracy and compliance of the model were evaluated using subject operating characteristic curves, area under the ROC curve, and calibration curves, and the model performance was estimated by self-lifting weight sampling. The Hosmer–Lemeshow test was used to assess the goodness of fit of the model.FindingsNARDS group consisted of 104, non-NARDS group consisted of 238 newborns in our study. Gestational age, triple concave sign, blood glucose measurement after birth (Glu), Apgar score at the 5th minute (Apgar5), neutrophil count (ANC) and platelet count (PLT) are independent predictors of NARDS in late preterm and term newborns who present with progressive respiratory distress and require varying degrees of respiratory support within the first 24 h of life to minimize work of breathing and restore organismal oxygenation. The area under the ROC curve was 0.829 (95% CI = 0.785–0.873), indicating the model's strong predictive power. In addition, decision curve analysis showed that the model had significantly better net benefits.ConclusionIn this study, a predictive column-line plot was constructed based on six clinically accessible conventional variables. Early application of this model has a better predictive effect on the early diagnosis of NARDS, thus facilitating more timely and effective interventions. |
| format | Article |
| id | doaj-art-733f0d47303647aa8a6c5479a3b490a3 |
| institution | Kabale University |
| issn | 2296-2360 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pediatrics |
| spelling | doaj-art-733f0d47303647aa8a6c5479a3b490a32025-01-09T06:10:55ZengFrontiers Media S.A.Frontiers in Pediatrics2296-23602025-01-011210.3389/fped.2024.14514661451466A nomogram for predicting neonatal acute respiratory distress syndrome in patients with neonatal pneumonia after 34 weeks of gestationAosong Yu0Huanhuan Hou1Huanhuan Hou2Lingyi Ran3Xiaojia Sun4Wanchun Xin5Tong Feng6Department of Pediatrics, Dandong Central Hospital, China Medical University, Dandong, ChinaDepartment of Pediatrics, Dandong Central Hospital, China Medical University, Dandong, ChinaSchool of Clinical Medicine, Xinjiang Medical University, Urumqi, ChinaSchool of Clinical Medicine, Xinjiang Medical University, Urumqi, ChinaSchool of Clinical Medicine, Xinjiang Medical University, Urumqi, ChinaSchool of Clinical Medicine, Xinjiang Medical University, Urumqi, ChinaDepartment of Pediatrics, Dandong Central Hospital, China Medical University, Dandong, ChinaObjectiveTo establish a prediction nomogram for early prediction of neonatal acute respiratory distress syndrome (NARDS).MethodsThis is a retrospective cross-sectional study conducted between January 2021 and December 2023. Clinical characteristics and laboratory results of cases with neonatal pneumonia were compared in terms of presence of NARDS diagnosis based on the Montreux Definition. The NARDS group and non-NARDS group were then compared to establish a prediction nomogram for early prediction of NARDS. The predictive accuracy and compliance of the model were evaluated using subject operating characteristic curves, area under the ROC curve, and calibration curves, and the model performance was estimated by self-lifting weight sampling. The Hosmer–Lemeshow test was used to assess the goodness of fit of the model.FindingsNARDS group consisted of 104, non-NARDS group consisted of 238 newborns in our study. Gestational age, triple concave sign, blood glucose measurement after birth (Glu), Apgar score at the 5th minute (Apgar5), neutrophil count (ANC) and platelet count (PLT) are independent predictors of NARDS in late preterm and term newborns who present with progressive respiratory distress and require varying degrees of respiratory support within the first 24 h of life to minimize work of breathing and restore organismal oxygenation. The area under the ROC curve was 0.829 (95% CI = 0.785–0.873), indicating the model's strong predictive power. In addition, decision curve analysis showed that the model had significantly better net benefits.ConclusionIn this study, a predictive column-line plot was constructed based on six clinically accessible conventional variables. Early application of this model has a better predictive effect on the early diagnosis of NARDS, thus facilitating more timely and effective interventions.https://www.frontiersin.org/articles/10.3389/fped.2024.1451466/fullneonatal acute respiratory distress syndromelate-preterm infantsfull-term infantsprediction nomogramneonatal pneumonia |
| spellingShingle | Aosong Yu Huanhuan Hou Huanhuan Hou Lingyi Ran Xiaojia Sun Wanchun Xin Tong Feng A nomogram for predicting neonatal acute respiratory distress syndrome in patients with neonatal pneumonia after 34 weeks of gestation Frontiers in Pediatrics neonatal acute respiratory distress syndrome late-preterm infants full-term infants prediction nomogram neonatal pneumonia |
| title | A nomogram for predicting neonatal acute respiratory distress syndrome in patients with neonatal pneumonia after 34 weeks of gestation |
| title_full | A nomogram for predicting neonatal acute respiratory distress syndrome in patients with neonatal pneumonia after 34 weeks of gestation |
| title_fullStr | A nomogram for predicting neonatal acute respiratory distress syndrome in patients with neonatal pneumonia after 34 weeks of gestation |
| title_full_unstemmed | A nomogram for predicting neonatal acute respiratory distress syndrome in patients with neonatal pneumonia after 34 weeks of gestation |
| title_short | A nomogram for predicting neonatal acute respiratory distress syndrome in patients with neonatal pneumonia after 34 weeks of gestation |
| title_sort | nomogram for predicting neonatal acute respiratory distress syndrome in patients with neonatal pneumonia after 34 weeks of gestation |
| topic | neonatal acute respiratory distress syndrome late-preterm infants full-term infants prediction nomogram neonatal pneumonia |
| url | https://www.frontiersin.org/articles/10.3389/fped.2024.1451466/full |
| work_keys_str_mv | AT aosongyu anomogramforpredictingneonatalacuterespiratorydistresssyndromeinpatientswithneonatalpneumoniaafter34weeksofgestation AT huanhuanhou anomogramforpredictingneonatalacuterespiratorydistresssyndromeinpatientswithneonatalpneumoniaafter34weeksofgestation AT huanhuanhou anomogramforpredictingneonatalacuterespiratorydistresssyndromeinpatientswithneonatalpneumoniaafter34weeksofgestation AT lingyiran anomogramforpredictingneonatalacuterespiratorydistresssyndromeinpatientswithneonatalpneumoniaafter34weeksofgestation AT xiaojiasun anomogramforpredictingneonatalacuterespiratorydistresssyndromeinpatientswithneonatalpneumoniaafter34weeksofgestation AT wanchunxin anomogramforpredictingneonatalacuterespiratorydistresssyndromeinpatientswithneonatalpneumoniaafter34weeksofgestation AT tongfeng anomogramforpredictingneonatalacuterespiratorydistresssyndromeinpatientswithneonatalpneumoniaafter34weeksofgestation AT aosongyu nomogramforpredictingneonatalacuterespiratorydistresssyndromeinpatientswithneonatalpneumoniaafter34weeksofgestation AT huanhuanhou nomogramforpredictingneonatalacuterespiratorydistresssyndromeinpatientswithneonatalpneumoniaafter34weeksofgestation AT huanhuanhou nomogramforpredictingneonatalacuterespiratorydistresssyndromeinpatientswithneonatalpneumoniaafter34weeksofgestation AT lingyiran nomogramforpredictingneonatalacuterespiratorydistresssyndromeinpatientswithneonatalpneumoniaafter34weeksofgestation AT xiaojiasun nomogramforpredictingneonatalacuterespiratorydistresssyndromeinpatientswithneonatalpneumoniaafter34weeksofgestation AT wanchunxin nomogramforpredictingneonatalacuterespiratorydistresssyndromeinpatientswithneonatalpneumoniaafter34weeksofgestation AT tongfeng nomogramforpredictingneonatalacuterespiratorydistresssyndromeinpatientswithneonatalpneumoniaafter34weeksofgestation |