Circadian Disruption Impacts Fetal Development in Mice Using High-Frequency Ultrasound
The developmental origins of health and disease theory suggests that environmental exposures during early life, particularly during prenatal life, can greatly influence health status later in life. Irregular light-dark cycles, such as those experienced during shift work, result in the repeated disru...
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| Language: | English |
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Ubiquity Press
2024-12-01
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| Series: | Journal of Circadian Rhythms |
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| Online Access: | https://account.jcircadianrhythms.com/index.php/up-j-jcr/article/view/249 |
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| author | Samantha M. Britz Shay Nelson Kylie M. Earhart James K. Pru Emily E. Schmitt |
| author_facet | Samantha M. Britz Shay Nelson Kylie M. Earhart James K. Pru Emily E. Schmitt |
| author_sort | Samantha M. Britz |
| collection | DOAJ |
| description | The developmental origins of health and disease theory suggests that environmental exposures during early life, particularly during prenatal life, can greatly influence health status later in life. Irregular light-dark cycles, such as those experienced during shift work, result in the repeated disruption of circadian rhythms, which negatively impacts physiological and behavioral cycles. The purpose of our study was to assess parameters in the developing mouse embryo and fetus using high frequency ultrasound when exposed to circadian disruption. Pregnant female mice were subjected to a seven-hour advanced circadian disrupted protocol or remained on a normal 12/12 light-dark cycle throughout pregnancy. Significant differences were observed in placental length (p = 0.00016), placental thickness (p = 0.0332), and stomach diameter (p = 0.0186) at E14.5–18.5. These findings suggest that circadian disruption in pregnant dams, mimicking shift work, alters embryonic and fetal development in specific organs in utero. |
| format | Article |
| id | doaj-art-732b945944164a57afb8f270498d9138 |
| institution | Kabale University |
| issn | 1740-3391 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Ubiquity Press |
| record_format | Article |
| series | Journal of Circadian Rhythms |
| spelling | doaj-art-732b945944164a57afb8f270498d91382025-01-08T07:58:30ZengUbiquity PressJournal of Circadian Rhythms1740-33912024-12-01224410.5334/jcr.249241Circadian Disruption Impacts Fetal Development in Mice Using High-Frequency UltrasoundSamantha M. Britz0Shay Nelson1Kylie M. Earhart2James K. Pru3https://orcid.org/0000-0003-2251-4494Emily E. Schmitt4https://orcid.org/0000-0001-6965-9768WWAMI Medical Education, University of Washington School of Medicine, Seattle, WAWWAMI Medical Education, University of Washington School of Medicine, Seattle, WADivision of Kinesiology & Health, University of Wyoming, Laramie, WYProgram in Reproductive Biology, Department of Animal Science, University of Wyoming, Laramie, WYWWAMI Medical Education, University of Washington School of Medicine, Seattle, WA; Division of Kinesiology & Health, University of Wyoming, Laramie, WYThe developmental origins of health and disease theory suggests that environmental exposures during early life, particularly during prenatal life, can greatly influence health status later in life. Irregular light-dark cycles, such as those experienced during shift work, result in the repeated disruption of circadian rhythms, which negatively impacts physiological and behavioral cycles. The purpose of our study was to assess parameters in the developing mouse embryo and fetus using high frequency ultrasound when exposed to circadian disruption. Pregnant female mice were subjected to a seven-hour advanced circadian disrupted protocol or remained on a normal 12/12 light-dark cycle throughout pregnancy. Significant differences were observed in placental length (p = 0.00016), placental thickness (p = 0.0332), and stomach diameter (p = 0.0186) at E14.5–18.5. These findings suggest that circadian disruption in pregnant dams, mimicking shift work, alters embryonic and fetal development in specific organs in utero.https://account.jcircadianrhythms.com/index.php/up-j-jcr/article/view/249circadian disruptiondevelopmentembryofetuspregnancyshift work |
| spellingShingle | Samantha M. Britz Shay Nelson Kylie M. Earhart James K. Pru Emily E. Schmitt Circadian Disruption Impacts Fetal Development in Mice Using High-Frequency Ultrasound Journal of Circadian Rhythms circadian disruption development embryo fetus pregnancy shift work |
| title | Circadian Disruption Impacts Fetal Development in Mice Using High-Frequency Ultrasound |
| title_full | Circadian Disruption Impacts Fetal Development in Mice Using High-Frequency Ultrasound |
| title_fullStr | Circadian Disruption Impacts Fetal Development in Mice Using High-Frequency Ultrasound |
| title_full_unstemmed | Circadian Disruption Impacts Fetal Development in Mice Using High-Frequency Ultrasound |
| title_short | Circadian Disruption Impacts Fetal Development in Mice Using High-Frequency Ultrasound |
| title_sort | circadian disruption impacts fetal development in mice using high frequency ultrasound |
| topic | circadian disruption development embryo fetus pregnancy shift work |
| url | https://account.jcircadianrhythms.com/index.php/up-j-jcr/article/view/249 |
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