Distinct late-stage osteoarthritis profiles identified through NF-κB, TNF-α, and TGF-β–driven synovial inflammation and pain

Distinct late-stage osteoarthritis profiles identified through NF-κB, TNF-α, and TGF-β–driven synovial inflammation and pain

Abstract This study delineates distinct late-stage osteoarthritis (OA) profiles, characterized by NF-κB, TNF-α, and TGF-β–mediated synovial inflammation and pain, in a cohort of 31 patients undergoing joint arthroplasty. Histopathological analysis demonstrated synoviocyte hyperplasia, increased stro...

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Bibliographic Details
Main Authors: Sofija Semenistaja, Liba Sokolovska, Simons Svirskis, Peteris Studers, Valerija Groma, Sandra Skuja
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Scientific Reports
Subjects:
Osteoarthritis
Synovial microenvironment
Inflammation
Pain perception
Statistical modeling
Online Access:https://doi.org/10.1038/s41598-025-16078-2
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