Recombinant Human Leptin Does Not Alter Gut Hormone Levels after Gastric Bypass but May Attenuate Sweet Cravings
Bariatric surgery improves glucose homeostasis and alters gut hormones partly independent of weight loss. Leptin plays a role in these processes; levels are decreased following bariatric surgery, creating a relative leptin insufficiency. We previously showed that leptin administration in a weight-re...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2014/120286 |
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| author | Rushika Conroy Gerardo Febres Donald J. McMahon Michael O. Thorner Bruce D. Gaylinn Irene Conwell Louis Aronne Judith Korner |
| author_facet | Rushika Conroy Gerardo Febres Donald J. McMahon Michael O. Thorner Bruce D. Gaylinn Irene Conwell Louis Aronne Judith Korner |
| author_sort | Rushika Conroy |
| collection | DOAJ |
| description | Bariatric surgery improves glucose homeostasis and alters gut hormones partly independent of weight loss. Leptin plays a role in these processes; levels are decreased following bariatric surgery, creating a relative leptin insufficiency. We previously showed that leptin administration in a weight-reduced state after Roux-en-Y gastric bypass (RYGB) caused no further weight loss. Here, we discuss the impact of leptin administration on gut hormones, glucostasis, and appetite. Weight stable women after RYGB were randomized to receive placebo or recombinant human metreleptin (0.05 mg/kg twice daily). At weeks 0 and 16, a liquid meal challenge was performed. Glucose, insulin, C-peptide, GLP-1, PYY, glucagon, and ghrelin (total, acyl, and desacyl) were measured fasting and postprandially. Appetite was assessed using a visual analog scale. Mean post-op period was 53±2.3 months; mean BMI was 34.6±0.2 kg/m2. At 16 weeks, there was no significant change in weight within or between groups. Fasting PYY was significantly different between groups and the leptin group had lower sweets craving at week 16 than the placebo group (P<0.05). No other differences were observed. Leptin replacement does not alter gut hormones or glucostasis but may diminish sweet cravings compared to placebo in this population of post-RYGB women. |
| format | Article |
| id | doaj-art-7327ce6437df46bf84cc4fa46df20467 |
| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
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| series | International Journal of Endocrinology |
| spelling | doaj-art-7327ce6437df46bf84cc4fa46df204672025-02-03T01:10:29ZengWileyInternational Journal of Endocrinology1687-83371687-83452014-01-01201410.1155/2014/120286120286Recombinant Human Leptin Does Not Alter Gut Hormone Levels after Gastric Bypass but May Attenuate Sweet CravingsRushika Conroy0Gerardo Febres1Donald J. McMahon2Michael O. Thorner3Bruce D. Gaylinn4Irene Conwell5Louis Aronne6Judith Korner7Division of Pediatric Endocrinology, Columbia University Medical Center, New York , NY 10032, USADivision of Endocrinology, Columbia University Medical Center, New York, NY 10032, USADivision of Endocrinology, Columbia University Medical Center, New York, NY 10032, USADivision of Medicine, University of Virginia Medical Center, Charlottesville, VA 22902, USADivision of Medicine, University of Virginia Medical Center, Charlottesville, VA 22902, USADivision of Endocrinology, Columbia University Medical Center, New York, NY 10032, USADivision of Medicine, Cornell University Medical Center, New York, NY 10021, USADivision of Endocrinology, Columbia University Medical Center, New York, NY 10032, USABariatric surgery improves glucose homeostasis and alters gut hormones partly independent of weight loss. Leptin plays a role in these processes; levels are decreased following bariatric surgery, creating a relative leptin insufficiency. We previously showed that leptin administration in a weight-reduced state after Roux-en-Y gastric bypass (RYGB) caused no further weight loss. Here, we discuss the impact of leptin administration on gut hormones, glucostasis, and appetite. Weight stable women after RYGB were randomized to receive placebo or recombinant human metreleptin (0.05 mg/kg twice daily). At weeks 0 and 16, a liquid meal challenge was performed. Glucose, insulin, C-peptide, GLP-1, PYY, glucagon, and ghrelin (total, acyl, and desacyl) were measured fasting and postprandially. Appetite was assessed using a visual analog scale. Mean post-op period was 53±2.3 months; mean BMI was 34.6±0.2 kg/m2. At 16 weeks, there was no significant change in weight within or between groups. Fasting PYY was significantly different between groups and the leptin group had lower sweets craving at week 16 than the placebo group (P<0.05). No other differences were observed. Leptin replacement does not alter gut hormones or glucostasis but may diminish sweet cravings compared to placebo in this population of post-RYGB women.http://dx.doi.org/10.1155/2014/120286 |
| spellingShingle | Rushika Conroy Gerardo Febres Donald J. McMahon Michael O. Thorner Bruce D. Gaylinn Irene Conwell Louis Aronne Judith Korner Recombinant Human Leptin Does Not Alter Gut Hormone Levels after Gastric Bypass but May Attenuate Sweet Cravings International Journal of Endocrinology |
| title | Recombinant Human Leptin Does Not Alter Gut Hormone Levels after Gastric Bypass but May Attenuate Sweet Cravings |
| title_full | Recombinant Human Leptin Does Not Alter Gut Hormone Levels after Gastric Bypass but May Attenuate Sweet Cravings |
| title_fullStr | Recombinant Human Leptin Does Not Alter Gut Hormone Levels after Gastric Bypass but May Attenuate Sweet Cravings |
| title_full_unstemmed | Recombinant Human Leptin Does Not Alter Gut Hormone Levels after Gastric Bypass but May Attenuate Sweet Cravings |
| title_short | Recombinant Human Leptin Does Not Alter Gut Hormone Levels after Gastric Bypass but May Attenuate Sweet Cravings |
| title_sort | recombinant human leptin does not alter gut hormone levels after gastric bypass but may attenuate sweet cravings |
| url | http://dx.doi.org/10.1155/2014/120286 |
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