Impact of infection in patients with non-ST elevation acute coronary syndrome undergoing percutaneous coronary intervention: insight from a multicentre observational cohort from China
Objective We aimed to describe the association between in-hospital infection and prognosis among patients with non-ST elevation acute coronary syndrome (NSTE-ACS) who received percutaneous coronary intervention (PCI).Design This observational cohort originated from a database of patients with NSTE-A...
Saved in:
| Main Authors: | , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMJ Publishing Group
2020-09-01
|
| Series: | BMJ Open |
| Online Access: | https://bmjopen.bmj.com/content/10/9/e038551.full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1841554105169870848 |
|---|---|
| author | Jun Li Lei Jiang Wei Chen Ning Tan Wei Guo Ji-yan Chen Yuan-hui Liu Peng-cheng He Peng-Yuan Chen Chong-Yang Duan Xue-Biao Wei Yin-Lin Zhou Zhu-Jun Chen Jian-Fang Luo Dan-Qing Yu Qing-Shan Geng Chun-Ying Lin Zhi-Qiang Guo Yan-Song Guo Yi-Yue Chen Wen-Sheng Li |
| author_facet | Jun Li Lei Jiang Wei Chen Ning Tan Wei Guo Ji-yan Chen Yuan-hui Liu Peng-cheng He Peng-Yuan Chen Chong-Yang Duan Xue-Biao Wei Yin-Lin Zhou Zhu-Jun Chen Jian-Fang Luo Dan-Qing Yu Qing-Shan Geng Chun-Ying Lin Zhi-Qiang Guo Yan-Song Guo Yi-Yue Chen Wen-Sheng Li |
| collection | DOAJ |
| description | Objective We aimed to describe the association between in-hospital infection and prognosis among patients with non-ST elevation acute coronary syndrome (NSTE-ACS) who received percutaneous coronary intervention (PCI).Design This observational cohort originated from a database of patients with NSTE-ACS who underwent PCI from 1 January 2010 to 31 December 2014.Setting Five centres in South China.Participants This multicentre observational cohort study consecutively included 8197 patients with NSTE-ACS who received PCI. Only patients with adequate information to diagnose or rule out infection were included. Patients were excluded if they were diagnosed with a malignant tumour, were pregnant or presented with cardiogenic shock at the index date. Patients were grouped by whether they had in-hospital infection or not.Primary and secondary outcome measures The primary outcome was all-cause death and major bleeding during hospitalisation. The secondary outcomes included all-cause death and major bleeding during follow-up and in-hospital myocardial infarction.Results Of the 5215 patients, 206 (3.95%) acquired infection. Patients with infection had a higher rate of in-hospital all-cause death and major bleeding (4.4% vs 0.2% and 16.5% vs 1.2%, respectively; p<0.001). After adjusting for confounders, infection remained independently associated with in-hospital and long-term all-cause death (OR, 13.19, 95% CI 4.59 to 37.87; HR, 2.03, 95% CI 1.52 to 2.71; p<0.001) and major bleeding (OR, 10.24, 95% CI 6.17 to 16.98; HR, 5.31, 95% CI 3.49 to 8.08; p<0.001). A subgroup analysis confirmed these results.Conclusions The incidence of infection is low during hospitalisation, but is associated with worse in-hospital and long-term outcomes. |
| format | Article |
| id | doaj-art-72ea90b2acad41cb9f149609c7ab727a |
| institution | Kabale University |
| issn | 2044-6055 |
| language | English |
| publishDate | 2020-09-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open |
| spelling | doaj-art-72ea90b2acad41cb9f149609c7ab727a2025-01-08T22:05:11ZengBMJ Publishing GroupBMJ Open2044-60552020-09-0110910.1136/bmjopen-2020-038551Impact of infection in patients with non-ST elevation acute coronary syndrome undergoing percutaneous coronary intervention: insight from a multicentre observational cohort from China 0Jun Li1Lei Jiang2Wei Chen3Ning Tan4Wei Guo5Ji-yan Chen6Yuan-hui Liu7Peng-cheng He8Peng-Yuan Chen9Chong-Yang Duan10Xue-Biao Wei11Yin-Lin ZhouZhu-Jun ChenJian-Fang LuoDan-Qing YuQing-Shan GengChun-Ying LinZhi-Qiang GuoYan-Song GuoYi-Yue ChenWen-Sheng LiGENYO, Pfizer-University, Granada, Spain, Granada, Spain1 Department of Neurosurgery, Center for Functional Neurosurgery, Shanghai Jiao Tong University Medical School Affiliated Ruijin Hospital, Shanghai, ChinaModerna Inc, Cambridge, Massachusetts, USA2 Department of Rehabilitation Medicine, XuZhou Central Hospital, Xuzhou, ChinaThe Second School of Clinical Medicine, Guangdong Provincial People’s Hospital, Southern Medical University, Guangzhou, ChinaDepartment of Cardiology, Guangdong Cardiovascular Institute, Guangdong Provincial Key Laboratory of Coronary Heart Disease Prevention, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Guangzhou, ChinaDepartment of Cardiology, Guangdong Cardiovascular Institute, Guangdong Provincial Key Laboratory of Coronary Heart Disease Prevention, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong, ChinaDepartment of Cardiology, Guangdong Cardiovascular Institute, Guangdong Provincial Key Laboratory of Coronary Heart Disease Prevention, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Guangzhou, ChinaDepartment of Cardiology, Guangdong Cardiovascular Institute, Guangdong Provincial Key Laboratory of Coronary Heart Disease Prevention, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Guangzhou, ChinaDepartment of Cardiology, Guangdong Provincial People’s Hospital’s Nanhai Hospital, the Second Hospital of Nanhai District Foshan City, Foshan, China17 Biostatistics, The State Key Laboratory of Organ Failure Research, The Key Laboratory of Tropical Disease Research, School of Public HealthMedical University, Guangzhou, Guangdong, ChinaDepartment of Cardiology, Guangdong Cardiovascular Institute, Guangdong Provincial Key Laboratory of Coronary Heart Disease Prevention, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Guangzhou, ChinaObjective We aimed to describe the association between in-hospital infection and prognosis among patients with non-ST elevation acute coronary syndrome (NSTE-ACS) who received percutaneous coronary intervention (PCI).Design This observational cohort originated from a database of patients with NSTE-ACS who underwent PCI from 1 January 2010 to 31 December 2014.Setting Five centres in South China.Participants This multicentre observational cohort study consecutively included 8197 patients with NSTE-ACS who received PCI. Only patients with adequate information to diagnose or rule out infection were included. Patients were excluded if they were diagnosed with a malignant tumour, were pregnant or presented with cardiogenic shock at the index date. Patients were grouped by whether they had in-hospital infection or not.Primary and secondary outcome measures The primary outcome was all-cause death and major bleeding during hospitalisation. The secondary outcomes included all-cause death and major bleeding during follow-up and in-hospital myocardial infarction.Results Of the 5215 patients, 206 (3.95%) acquired infection. Patients with infection had a higher rate of in-hospital all-cause death and major bleeding (4.4% vs 0.2% and 16.5% vs 1.2%, respectively; p<0.001). After adjusting for confounders, infection remained independently associated with in-hospital and long-term all-cause death (OR, 13.19, 95% CI 4.59 to 37.87; HR, 2.03, 95% CI 1.52 to 2.71; p<0.001) and major bleeding (OR, 10.24, 95% CI 6.17 to 16.98; HR, 5.31, 95% CI 3.49 to 8.08; p<0.001). A subgroup analysis confirmed these results.Conclusions The incidence of infection is low during hospitalisation, but is associated with worse in-hospital and long-term outcomes.https://bmjopen.bmj.com/content/10/9/e038551.full |
| spellingShingle | Jun Li Lei Jiang Wei Chen Ning Tan Wei Guo Ji-yan Chen Yuan-hui Liu Peng-cheng He Peng-Yuan Chen Chong-Yang Duan Xue-Biao Wei Yin-Lin Zhou Zhu-Jun Chen Jian-Fang Luo Dan-Qing Yu Qing-Shan Geng Chun-Ying Lin Zhi-Qiang Guo Yan-Song Guo Yi-Yue Chen Wen-Sheng Li Impact of infection in patients with non-ST elevation acute coronary syndrome undergoing percutaneous coronary intervention: insight from a multicentre observational cohort from China BMJ Open |
| title | Impact of infection in patients with non-ST elevation acute coronary syndrome undergoing percutaneous coronary intervention: insight from a multicentre observational cohort from China |
| title_full | Impact of infection in patients with non-ST elevation acute coronary syndrome undergoing percutaneous coronary intervention: insight from a multicentre observational cohort from China |
| title_fullStr | Impact of infection in patients with non-ST elevation acute coronary syndrome undergoing percutaneous coronary intervention: insight from a multicentre observational cohort from China |
| title_full_unstemmed | Impact of infection in patients with non-ST elevation acute coronary syndrome undergoing percutaneous coronary intervention: insight from a multicentre observational cohort from China |
| title_short | Impact of infection in patients with non-ST elevation acute coronary syndrome undergoing percutaneous coronary intervention: insight from a multicentre observational cohort from China |
| title_sort | impact of infection in patients with non st elevation acute coronary syndrome undergoing percutaneous coronary intervention insight from a multicentre observational cohort from china |
| url | https://bmjopen.bmj.com/content/10/9/e038551.full |
| work_keys_str_mv | AT impactofinfectioninpatientswithnonstelevationacutecoronarysyndromeundergoingpercutaneouscoronaryinterventioninsightfromamulticentreobservationalcohortfromchina AT junli impactofinfectioninpatientswithnonstelevationacutecoronarysyndromeundergoingpercutaneouscoronaryinterventioninsightfromamulticentreobservationalcohortfromchina AT leijiang impactofinfectioninpatientswithnonstelevationacutecoronarysyndromeundergoingpercutaneouscoronaryinterventioninsightfromamulticentreobservationalcohortfromchina AT weichen impactofinfectioninpatientswithnonstelevationacutecoronarysyndromeundergoingpercutaneouscoronaryinterventioninsightfromamulticentreobservationalcohortfromchina AT ningtan impactofinfectioninpatientswithnonstelevationacutecoronarysyndromeundergoingpercutaneouscoronaryinterventioninsightfromamulticentreobservationalcohortfromchina AT weiguo impactofinfectioninpatientswithnonstelevationacutecoronarysyndromeundergoingpercutaneouscoronaryinterventioninsightfromamulticentreobservationalcohortfromchina AT jiyanchen impactofinfectioninpatientswithnonstelevationacutecoronarysyndromeundergoingpercutaneouscoronaryinterventioninsightfromamulticentreobservationalcohortfromchina AT yuanhuiliu impactofinfectioninpatientswithnonstelevationacutecoronarysyndromeundergoingpercutaneouscoronaryinterventioninsightfromamulticentreobservationalcohortfromchina AT pengchenghe impactofinfectioninpatientswithnonstelevationacutecoronarysyndromeundergoingpercutaneouscoronaryinterventioninsightfromamulticentreobservationalcohortfromchina AT pengyuanchen impactofinfectioninpatientswithnonstelevationacutecoronarysyndromeundergoingpercutaneouscoronaryinterventioninsightfromamulticentreobservationalcohortfromchina AT chongyangduan impactofinfectioninpatientswithnonstelevationacutecoronarysyndromeundergoingpercutaneouscoronaryinterventioninsightfromamulticentreobservationalcohortfromchina AT xuebiaowei impactofinfectioninpatientswithnonstelevationacutecoronarysyndromeundergoingpercutaneouscoronaryinterventioninsightfromamulticentreobservationalcohortfromchina AT yinlinzhou impactofinfectioninpatientswithnonstelevationacutecoronarysyndromeundergoingpercutaneouscoronaryinterventioninsightfromamulticentreobservationalcohortfromchina AT zhujunchen impactofinfectioninpatientswithnonstelevationacutecoronarysyndromeundergoingpercutaneouscoronaryinterventioninsightfromamulticentreobservationalcohortfromchina AT jianfangluo impactofinfectioninpatientswithnonstelevationacutecoronarysyndromeundergoingpercutaneouscoronaryinterventioninsightfromamulticentreobservationalcohortfromchina AT danqingyu impactofinfectioninpatientswithnonstelevationacutecoronarysyndromeundergoingpercutaneouscoronaryinterventioninsightfromamulticentreobservationalcohortfromchina AT qingshangeng impactofinfectioninpatientswithnonstelevationacutecoronarysyndromeundergoingpercutaneouscoronaryinterventioninsightfromamulticentreobservationalcohortfromchina AT chunyinglin impactofinfectioninpatientswithnonstelevationacutecoronarysyndromeundergoingpercutaneouscoronaryinterventioninsightfromamulticentreobservationalcohortfromchina AT zhiqiangguo impactofinfectioninpatientswithnonstelevationacutecoronarysyndromeundergoingpercutaneouscoronaryinterventioninsightfromamulticentreobservationalcohortfromchina AT yansongguo impactofinfectioninpatientswithnonstelevationacutecoronarysyndromeundergoingpercutaneouscoronaryinterventioninsightfromamulticentreobservationalcohortfromchina AT yiyuechen impactofinfectioninpatientswithnonstelevationacutecoronarysyndromeundergoingpercutaneouscoronaryinterventioninsightfromamulticentreobservationalcohortfromchina AT wenshengli impactofinfectioninpatientswithnonstelevationacutecoronarysyndromeundergoingpercutaneouscoronaryinterventioninsightfromamulticentreobservationalcohortfromchina |