Exploring Regulation of Chinese Medicine on Osteoclasts Based on OPG/RANKL/RANK Signaling Pathway
As the balance of bone metabolism, osteoclasts are closely related to the quantity and activity of bone metabolism. The discovery of osteoprotegerin (OPG) /RANKL/RANK signaling pathway is a new breakthrough in the study of bone metabolism as the key of maintaining bone balance. Important molecular r...
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| Format: | Article |
| Language: | English |
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Editorial Office of Rehabilitation Medicine
2018-10-01
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| Series: | 康复学报 |
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| Online Access: | http://kfxb.publish.founderss.cn/thesisDetails#10.3724/SP.J.1329.2018.05059 |
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| author | Chutian ZHANG Yanping LIN |
| author_facet | Chutian ZHANG Yanping LIN |
| author_sort | Chutian ZHANG |
| collection | DOAJ |
| description | As the balance of bone metabolism, osteoclasts are closely related to the quantity and activity of bone metabolism. The discovery of osteoprotegerin (OPG) /RANKL/RANK signaling pathway is a new breakthrough in the study of bone metabolism as the key of maintaining bone balance. Important molecular regulatory mechanisms play a key role in osteoclast precursor cell differentiation and bone resorption, and are the new directions in anti-osteoporosis drug research. Traditional Chinese medicine treatment of osteoporosis has a good clinical effect, but the mechanism of drug intervention in bone metabolism is not yet completely clear. In this paper, the recent studies on osteoclast biology and interventions and mechanisms of Chinese medicine on osteoclasts from the perspective of OPG/RANKL/RANK signaling pathway are summarized through reviewing the relevant literatures both at home and abroad. |
| format | Article |
| id | doaj-art-72c811a9953a48f89d5438f7d00fcbce |
| institution | Kabale University |
| issn | 2096-0328 |
| language | English |
| publishDate | 2018-10-01 |
| publisher | Editorial Office of Rehabilitation Medicine |
| record_format | Article |
| series | 康复学报 |
| spelling | doaj-art-72c811a9953a48f89d5438f7d00fcbce2025-01-14T10:04:56ZengEditorial Office of Rehabilitation Medicine康复学报2096-03282018-10-01285964,7023128223Exploring Regulation of Chinese Medicine on Osteoclasts Based on OPG/RANKL/RANK Signaling PathwayChutian ZHANGYanping LINAs the balance of bone metabolism, osteoclasts are closely related to the quantity and activity of bone metabolism. The discovery of osteoprotegerin (OPG) /RANKL/RANK signaling pathway is a new breakthrough in the study of bone metabolism as the key of maintaining bone balance. Important molecular regulatory mechanisms play a key role in osteoclast precursor cell differentiation and bone resorption, and are the new directions in anti-osteoporosis drug research. Traditional Chinese medicine treatment of osteoporosis has a good clinical effect, but the mechanism of drug intervention in bone metabolism is not yet completely clear. In this paper, the recent studies on osteoclast biology and interventions and mechanisms of Chinese medicine on osteoclasts from the perspective of OPG/RANKL/RANK signaling pathway are summarized through reviewing the relevant literatures both at home and abroad.http://kfxb.publish.founderss.cn/thesisDetails#10.3724/SP.J.1329.2018.05059osteoporosisOPG/RANKL/RANK signaling pathwayChinese medicineosteoclast |
| spellingShingle | Chutian ZHANG Yanping LIN Exploring Regulation of Chinese Medicine on Osteoclasts Based on OPG/RANKL/RANK Signaling Pathway 康复学报 osteoporosis OPG/RANKL/RANK signaling pathway Chinese medicine osteoclast |
| title | Exploring Regulation of Chinese Medicine on Osteoclasts Based on OPG/RANKL/RANK Signaling Pathway |
| title_full | Exploring Regulation of Chinese Medicine on Osteoclasts Based on OPG/RANKL/RANK Signaling Pathway |
| title_fullStr | Exploring Regulation of Chinese Medicine on Osteoclasts Based on OPG/RANKL/RANK Signaling Pathway |
| title_full_unstemmed | Exploring Regulation of Chinese Medicine on Osteoclasts Based on OPG/RANKL/RANK Signaling Pathway |
| title_short | Exploring Regulation of Chinese Medicine on Osteoclasts Based on OPG/RANKL/RANK Signaling Pathway |
| title_sort | exploring regulation of chinese medicine on osteoclasts based on opg rankl rank signaling pathway |
| topic | osteoporosis OPG/RANKL/RANK signaling pathway Chinese medicine osteoclast |
| url | http://kfxb.publish.founderss.cn/thesisDetails#10.3724/SP.J.1329.2018.05059 |
| work_keys_str_mv | AT chutianzhang exploringregulationofchinesemedicineonosteoclastsbasedonopgranklranksignalingpathway AT yanpinglin exploringregulationofchinesemedicineonosteoclastsbasedonopgranklranksignalingpathway |