Role of neutrophils and NETs in osteosarcoma and soft tissue sarcoma
Neutrophils are one of the important components of the tumor microenvironment. Neutrophil extra cellular traps (NETs) are a network structure released by neutrophils, and their formation process is called neutrophil inflammatory apoptosis (NETosis). Neutrophils in the tumor microenvironment, also kn...
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| Format: | Article |
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| Language: | zho |
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Institute of Basic Medical Sciences and Peking Union Medical College Hospital, Chinese Academy of Medical Sciences / Peking Union Medical College.
2024-10-01
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| Series: | Jichu yixue yu linchuang |
| Subjects: | |
| Online Access: | https://journal11.magtechjournal.com/Jwk_jcyxylc/fileup/1001-6325/PDF/1001-6325-2024-44-10-1442.pdf |
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| collection | DOAJ |
| description | Neutrophils are one of the important components of the tumor microenvironment. Neutrophil extra cellular traps (NETs) are a network structure released by neutrophils, and their formation process is called neutrophil inflammatory apoptosis (NETosis). Neutrophils in the tumor microenvironment, also known as tumor associated neutrophils (TANs). TANs including N1 phenotype and N2 phenotype have a bidirectional regulatory effect on tumors. While N1 phenotype inhibits tumor growth, and N2 phenotype promotes tumor growth, and N1 and N2 types undergo mutual transformation due to the influence of the tumor microenvironment. Neutrophils and NETs also play important roles in bone and osteosarcoma tissue sarcoma, which can affect tumor progression and predict patient prognosis. Blocking the formation of NETs may be a potential therapeutic target. |
| format | Article |
| id | doaj-art-729a94d49c314e6d8a6a681601a7979d |
| institution | Kabale University |
| issn | 1001-6325 |
| language | zho |
| publishDate | 2024-10-01 |
| publisher | Institute of Basic Medical Sciences and Peking Union Medical College Hospital, Chinese Academy of Medical Sciences / Peking Union Medical College. |
| record_format | Article |
| series | Jichu yixue yu linchuang |
| spelling | doaj-art-729a94d49c314e6d8a6a681601a7979d2024-11-12T06:26:09ZzhoInstitute of Basic Medical Sciences and Peking Union Medical College Hospital, Chinese Academy of Medical Sciences / Peking Union Medical College.Jichu yixue yu linchuang1001-63252024-10-0144101442144610.16352/j.issn.1001-6325.2024.10.1442Role of neutrophils and NETs in osteosarcoma and soft tissue sarcoma0Department of Pathology, the Second Affiliated Hospital of Guangzhou Medical University, Guangzhou 510260, ChinaNeutrophils are one of the important components of the tumor microenvironment. Neutrophil extra cellular traps (NETs) are a network structure released by neutrophils, and their formation process is called neutrophil inflammatory apoptosis (NETosis). Neutrophils in the tumor microenvironment, also known as tumor associated neutrophils (TANs). TANs including N1 phenotype and N2 phenotype have a bidirectional regulatory effect on tumors. While N1 phenotype inhibits tumor growth, and N2 phenotype promotes tumor growth, and N1 and N2 types undergo mutual transformation due to the influence of the tumor microenvironment. Neutrophils and NETs also play important roles in bone and osteosarcoma tissue sarcoma, which can affect tumor progression and predict patient prognosis. Blocking the formation of NETs may be a potential therapeutic target.https://journal11.magtechjournal.com/Jwk_jcyxylc/fileup/1001-6325/PDF/1001-6325-2024-44-10-1442.pdfosteosarcoma|soft tissue sarcoma|neutrophil|neutrophil extracellular traps|tumor-associated neutrophils |
| spellingShingle | Role of neutrophils and NETs in osteosarcoma and soft tissue sarcoma Jichu yixue yu linchuang osteosarcoma|soft tissue sarcoma|neutrophil|neutrophil extracellular traps|tumor-associated neutrophils |
| title | Role of neutrophils and NETs in osteosarcoma and soft tissue sarcoma |
| title_full | Role of neutrophils and NETs in osteosarcoma and soft tissue sarcoma |
| title_fullStr | Role of neutrophils and NETs in osteosarcoma and soft tissue sarcoma |
| title_full_unstemmed | Role of neutrophils and NETs in osteosarcoma and soft tissue sarcoma |
| title_short | Role of neutrophils and NETs in osteosarcoma and soft tissue sarcoma |
| title_sort | role of neutrophils and nets in osteosarcoma and soft tissue sarcoma |
| topic | osteosarcoma|soft tissue sarcoma|neutrophil|neutrophil extracellular traps|tumor-associated neutrophils |
| url | https://journal11.magtechjournal.com/Jwk_jcyxylc/fileup/1001-6325/PDF/1001-6325-2024-44-10-1442.pdf |