Epoetin-alfa-induced osteogenesis in the bone organoid model

Epoetin-alfa-induced osteogenesis in the bone organoid model

Introduction: Erythropoietin interacts ETwith EPOR/βcR(CD131) and activates the non-canonical pathway JAK/STAT and PI3K/AKT. Phosphorylated STAT subunits were found to get dimerized and translocated into the nucleus to activate the expression of the Runx-2 and TGF-β genes. The purpose of the study w...

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Main Authors: Natalia A. Nadezhdina, Oleg S. Gudyrev, Sergey V. Nadezhdin, Lyudmila M. Danilenko, Aleksandr A. Dolzhikov, Kristina K. Kremleva, Tatyana G. Pokrovskaya
Format: Article
Language:English
Published: Belgorod National Research University 2024-12-01
Series:Research Results in Pharmacology
Subjects:
epoetin alfa
trabecular bone organoid
osteogenesis
Online Access:https://rrpharmacology.ru/index.php/journal/article/view/517
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