CFTR氯通道调控小鼠内毒素血症血小板活化及炎症因子生成
目的囊性纤维化跨膜转导调节因子（CFTR）氯通道参与血小板活化的调控。本研究探讨CFTR氯通道对脂多糖（LPS）引起的内毒素血症过程中血小板活化、血小板数目及血小板介导炎症因子生成的影响。方法应用8~12周龄CFTR全基因敲除（<italic>Cftr<sup>-/-</sup></italic>）小鼠及野生型（<italic>Cftr</italic><sup>+/+</sup>）小鼠，制备股静脉注射LPS诱导内毒素血症模型。分离小鼠外周血的血小板，采用免疫印迹法检测TLR4蛋白的表达，采用实时定...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | zho |
| Published: |
Editorial Office of Journal of Sun Yat-sen University
2022-05-01
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| Series: | Zhongshan Daxue xuebao. Yixue kexue ban |
| Subjects: | |
| Online Access: | http://xuebaoyx.sysu.edu.cn/zh/article/doi/10.13471/j.cnki.j.sun.yat-sen.univ(med.sci).2022.0302/ |
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