Multiomics profiling of DNA methylation, microRNA, and mRNA in skeletal muscle from monozygotic twin pairs discordant for type 2 diabetes identifies dysregulated genes controlling metabolism

Multiomics profiling of DNA methylation, microRNA, and mRNA in skeletal muscle from monozygotic twin pairs discordant for type 2 diabetes identifies dysregulated genes controlling metabolism

Abstract Background A large proportion of skeletal muscle insulin resistance in type 2 diabetes (T2D) is caused by environmental factors. Methods By applying multiomics mRNA, microRNA (miRNA), and DNA methylation platforms in biopsies from 20 monozygotic twin pairs discordant for T2D, we aimed to de...

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Main Authors: Charlotte Ling, Magdalena Vavakova, Bilal Ahmad Mir, Johanna Säll, Alexander Perfilyev, Melina Martin, Per-Anders Jansson, Cajsa Davegårdh, Olof Asplund, Ola Hansson, Allan Vaag, Emma Nilsson
Format: Article
Language:English
Published: BMC 2024-12-01
Series:BMC Medicine
Subjects:
Type 2 diabetes (T2D)
Skeletal muscle
DNA methylation
Epigenetics
Gene expression
MicroRNA (miRNA)
Online Access:https://doi.org/10.1186/s12916-024-03789-y
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https://doi.org/10.1186/s12916-024-03789-y

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