IFNα gene/cell therapy curbs colorectal cancer colonization of the liver by acting on the hepatic microenvironment

IFNα gene/cell therapy curbs colorectal cancer colonization of the liver by acting on the hepatic microenvironment

Abstract Colorectal cancer (CRC) metastatic dissemination to the liver is one of the most life‐threatening malignancies in humans and represents the leading cause of CRC‐related mortality. Herein, we adopted a gene transfer strategy into mouse hematopoietic stem/progenitor cells to generate immune‐c...

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Main Authors: Mario Catarinella, Andrea Monestiroli, Giulia Escobar, Amleto Fiocchi, Ngoc Lan Tran, Roberto Aiolfi, Paolo Marra, Antonio Esposito, Federica Cipriani, Luca Aldrighetti, Matteo Iannacone, Luigi Naldini, Luca G Guidotti, Giovanni Sitia
Format: Article
Language:English
Published: Springer Nature 2016-01-01
Series:EMBO Molecular Medicine
Subjects:
colorectal cancer
gene therapy
interferon‐alpha
liver metastases
tumor microenvironment
Online Access:https://doi.org/10.15252/emmm.201505395
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