Molecular characteristics of NPM1 mutations in AML patients using targeted NGS

Molecular characteristics of NPM1 mutations in AML patients using targeted NGS

Background Acute myeloid leukemia (AML) is a clonal hematopoietic stem cell malignancy characterized by the accumulation of myeloid progenitor cells with arrested differentiation, leading to the suppression of normal hematopoiesis. The disease exhibits significant heterogeneity, with less than 30% f...

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Bibliographic Details
Main Authors: Reham AboElwafa, Magdy Elbordiny, Ashraf Elghandour, Rania Swelem, Sherouk Shoeib
Format: Article
Language:English
Published: Taylor & Francis Group 2024-12-01
Series:Alexandria Journal of Medicine
Subjects:
Acute myeloid leukemia (AML)
Nucleophosmin 1 (NPM1)
targeted sequencing (NGS)
variant allele frequency (VAF)
indel mutations
Online Access:https://www.tandfonline.com/doi/10.1080/20905068.2024.2395583
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