Lesson from a metastatic male breast cancer case: CDK4/6 plus aromatase inhibitors could not exceed tamoxifen
Abstract Male breast cancer (MaBC) is a rare disease, and treatment approaches are often extrapolated from female breast cancer protocols. We present the case of a 55-year-old male diagnosed with estrogen receptor-positive metastatic breast cancer who exhibited primary resistance to first-line treat...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Springer
2025-05-01
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| Series: | Discover Oncology |
| Subjects: | |
| Online Access: | https://doi.org/10.1007/s12672-025-02571-7 |
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| Summary: | Abstract Male breast cancer (MaBC) is a rare disease, and treatment approaches are often extrapolated from female breast cancer protocols. We present the case of a 55-year-old male diagnosed with estrogen receptor-positive metastatic breast cancer who exhibited primary resistance to first-line treatment with a combination of Palbociclib (CDK4/6 inhibitor) and Letrozole (aromatase inhibitor), despite the proven efficacy of this combination in female breast cancer. Surprisingly, upon switching to Tamoxifen, the patient showed rapid and significant clinical improvement documented as a good partial response on radiologic assessment. This case highlights the potential limitations of CDK4/6 inhibitors plus aromatase inhibitors in MaBC and suggests that Tamoxifen could remain a more reliable first-line endocrine therapy in males. It underscores the need for cautious extrapolation of female breast cancer treatment strategies to MaBC and emphasizes the adherence to classical approaches, such as tamoxifen. |
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| ISSN: | 2730-6011 |