Prevalence and factors associated with high risk for obstructive sleep apnea in schizophrenia spectrum disorder patients on long-term clozapine
Aim: This study aimed to evaluate the prevalence of obstructive sleep apnea (OSA) and its correlates among schizophrenia spectrum disorder patients receiving clozapine. Methods: For this, 200 schizophrenia spectrum disorder patients receiving clozapine for at least one year were assessed on the Berl...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2024-12-01
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| Series: | Indian Journal of Psychiatry |
| Subjects: | |
| Online Access: | https://journals.lww.com/10.4103/indianjpsychiatry.indianjpsychiatry_544_24 |
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| Summary: | Aim:
This study aimed to evaluate the prevalence of obstructive sleep apnea (OSA) and its correlates among schizophrenia spectrum disorder patients receiving clozapine.
Methods:
For this, 200 schizophrenia spectrum disorder patients receiving clozapine for at least one year were assessed on the Berlin Sleep Questionnaire for OSA.
Results:
Around one-sixth of the study sample (16.5%) had a high risk for OSA at a body mass index (BMI) cut-off of 30 kg/m2. When a BMI cut-off of 25 kg/m2 was used, the prevalence of OSA was 36%. A high risk for OSA is associated with a higher prevalence of depression, a higher number of psychiatric comorbidities, diabetes mellitus, a higher mean total chlorpromazine equivalent dose, a higher number of total medications, poorer quality of life in some of the domains, and scored high for all domains and the total score of UKU.
Conclusion:
To conclude, this study suggests that a high risk of OSA is associated with the presence of depression, a higher number of psychiatric comorbidities, diabetes mellitus, use of higher total chlorpromazine equivalent dose, the total number of medications, poorer quality of life, and a higher prevalence of other side effects. |
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| ISSN: | 0019-5545 1998-3794 |