(<i>E</i>)-1-(Benzo[<i>d</i>][1,3]dioxol-5-yl)-5,6,6-trimethylhept-4-en-3-one
The title compound (<b>1</b>) was obtained within a project to synthesize analogs of the antiepileptic drug stiripentol. Compound <b>1</b> was synthesized by aldol addition of the lithium enolate of 4-(benzo[<i>d</i>][1,3]dioxol-5-yl)butan-2-one (<b>2</b&...
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| Language: | English |
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2024-12-01
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| Online Access: | https://www.mdpi.com/1422-8599/2024/4/M1938 |
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| author | Mario Rico-Molina Joaquín Altarejos Sofía Salido |
| author_facet | Mario Rico-Molina Joaquín Altarejos Sofía Salido |
| author_sort | Mario Rico-Molina |
| collection | DOAJ |
| description | The title compound (<b>1</b>) was obtained within a project to synthesize analogs of the antiepileptic drug stiripentol. Compound <b>1</b> was synthesized by aldol addition of the lithium enolate of 4-(benzo[<i>d</i>][1,3]dioxol-5-yl)butan-2-one (<b>2</b>) to 3,3-dimethylbutan-2-one (<b>3</b>), followed by the dehydration of the resulting β-hydroxy-ketone under acid processing. The structure of <b>1</b> was established by 1D and 2D NMR spectroscopy and high-resolution mass spectrometry. |
| format | Article |
| id | doaj-art-71fdc7f933dc4a758fc91e934c9dca3f |
| institution | Kabale University |
| issn | 1422-8599 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molbank |
| spelling | doaj-art-71fdc7f933dc4a758fc91e934c9dca3f2024-12-27T14:42:18ZengMDPI AGMolbank1422-85992024-12-0120244M193810.3390/M1938(<i>E</i>)-1-(Benzo[<i>d</i>][1,3]dioxol-5-yl)-5,6,6-trimethylhept-4-en-3-oneMario Rico-Molina0Joaquín Altarejos1Sofía Salido2Department of Inorganic and Organic Chemistry, Faculty of Experimental Sciences, University of Jaén, Campus of International Excellence in Agri-Food (ceiA3), 23071 Jaen, SpainDepartment of Inorganic and Organic Chemistry, Faculty of Experimental Sciences, University of Jaén, Campus of International Excellence in Agri-Food (ceiA3), 23071 Jaen, SpainDepartment of Inorganic and Organic Chemistry, Faculty of Experimental Sciences, University of Jaén, Campus of International Excellence in Agri-Food (ceiA3), 23071 Jaen, SpainThe title compound (<b>1</b>) was obtained within a project to synthesize analogs of the antiepileptic drug stiripentol. Compound <b>1</b> was synthesized by aldol addition of the lithium enolate of 4-(benzo[<i>d</i>][1,3]dioxol-5-yl)butan-2-one (<b>2</b>) to 3,3-dimethylbutan-2-one (<b>3</b>), followed by the dehydration of the resulting β-hydroxy-ketone under acid processing. The structure of <b>1</b> was established by 1D and 2D NMR spectroscopy and high-resolution mass spectrometry.https://www.mdpi.com/1422-8599/2024/4/M1938stiripentol analogsaldol additionlithium enolateacid dehydration |
| spellingShingle | Mario Rico-Molina Joaquín Altarejos Sofía Salido (<i>E</i>)-1-(Benzo[<i>d</i>][1,3]dioxol-5-yl)-5,6,6-trimethylhept-4-en-3-one Molbank stiripentol analogs aldol addition lithium enolate acid dehydration |
| title | (<i>E</i>)-1-(Benzo[<i>d</i>][1,3]dioxol-5-yl)-5,6,6-trimethylhept-4-en-3-one |
| title_full | (<i>E</i>)-1-(Benzo[<i>d</i>][1,3]dioxol-5-yl)-5,6,6-trimethylhept-4-en-3-one |
| title_fullStr | (<i>E</i>)-1-(Benzo[<i>d</i>][1,3]dioxol-5-yl)-5,6,6-trimethylhept-4-en-3-one |
| title_full_unstemmed | (<i>E</i>)-1-(Benzo[<i>d</i>][1,3]dioxol-5-yl)-5,6,6-trimethylhept-4-en-3-one |
| title_short | (<i>E</i>)-1-(Benzo[<i>d</i>][1,3]dioxol-5-yl)-5,6,6-trimethylhept-4-en-3-one |
| title_sort | i e i 1 benzo i d i 1 3 dioxol 5 yl 5 6 6 trimethylhept 4 en 3 one |
| topic | stiripentol analogs aldol addition lithium enolate acid dehydration |
| url | https://www.mdpi.com/1422-8599/2024/4/M1938 |
| work_keys_str_mv | AT marioricomolina iei1benzoidi13dioxol5yl566trimethylhept4en3one AT joaquinaltarejos iei1benzoidi13dioxol5yl566trimethylhept4en3one AT sofiasalido iei1benzoidi13dioxol5yl566trimethylhept4en3one |