Deconvoluting zavegepant drug–drug interactions: A phase I study to evaluate the effects of rifampin and itraconazole on zavegepant pharmacokinetics

Deconvoluting zavegepant drug–drug interactions: A phase I study to evaluate the effects of rifampin and itraconazole on zavegepant pharmacokinetics

Abstract Zavegepant is a calcitonin gene‐related peptide receptor antagonist for acute migraine treatment. This Phase I, open‐label, fixed‐sequence study evaluated the effects of itraconazole (a strong cytochrome P450 3A4 [CYP3A4] and P‐glycoprotein [P‐gp] inhibitor) on the pharmacokinetics of intra...

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Bibliographic Details
Main Authors: Rajinder Bhardwaj, Jo Ann Malatesta, Jennifer Madonia, Matt S. Anderson, Beth Morris, Kyle T. Matschke, Robert Croop, Richard Bertz, Jing Liu
Format: Article
Language:English
Published: Wiley 2024-12-01
Series:Clinical and Translational Science
Online Access:https://doi.org/10.1111/cts.70048
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