The role of pH in symptomatic relief and effective treatment of gastroesophageal reflux disease
Gastroesophageal reflux disease (GERD) is a condition in which gastroduodenal contents pass into the oesophagus and cause troublesome symptoms and complications. The aetiopathogenesis of gastroesophageal reflux disease is complex and multifactorial. Acid reflux plays an important role in the GERD pa...
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| Format: | Article |
| Language: | English |
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Termedia Publishing House
2017-12-01
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| Series: | Gastroenterology Review |
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| Online Access: | https://www.termedia.pl/The-role-of-pH-in-symptomatic-relief-and-effective-treatment-of-gastroesophageal-reflux-disease,41,31240,1,1.html |
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| _version_ | 1841548314985627648 |
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| author | Anita Gąsiorowska |
| author_facet | Anita Gąsiorowska |
| author_sort | Anita Gąsiorowska |
| collection | DOAJ |
| description | Gastroesophageal reflux disease (GERD) is a condition in which gastroduodenal contents pass into the oesophagus and cause troublesome symptoms and complications. The aetiopathogenesis of gastroesophageal reflux disease is complex and multifactorial. Acid reflux plays an important role in the GERD pathogenesis, both in erosive and non-erosive reflux disease. Reduction of GERD symptoms and mucosal healing correlates with the number of hours that intragastric acid is suppressed to a pH > 4.0. Mucosal healing was achieved in most of patients who received different types of proton pump inhibitors, but only in 50% of those who received H2 blockers. These findings seem to be best accounted for by differences in the duration and degree of acid suppression achieved by different classes of drugs and perhaps between agents within those classes. |
| format | Article |
| id | doaj-art-71e60195c8b1427eb37863faec34c8d3 |
| institution | Kabale University |
| issn | 1895-5770 1897-4317 |
| language | English |
| publishDate | 2017-12-01 |
| publisher | Termedia Publishing House |
| record_format | Article |
| series | Gastroenterology Review |
| spelling | doaj-art-71e60195c8b1427eb37863faec34c8d32025-01-10T14:06:17ZengTermedia Publishing HouseGastroenterology Review1895-57701897-43172017-12-0112424424910.5114/pg.2017.7209731240The role of pH in symptomatic relief and effective treatment of gastroesophageal reflux diseaseAnita GąsiorowskaGastroesophageal reflux disease (GERD) is a condition in which gastroduodenal contents pass into the oesophagus and cause troublesome symptoms and complications. The aetiopathogenesis of gastroesophageal reflux disease is complex and multifactorial. Acid reflux plays an important role in the GERD pathogenesis, both in erosive and non-erosive reflux disease. Reduction of GERD symptoms and mucosal healing correlates with the number of hours that intragastric acid is suppressed to a pH > 4.0. Mucosal healing was achieved in most of patients who received different types of proton pump inhibitors, but only in 50% of those who received H2 blockers. These findings seem to be best accounted for by differences in the duration and degree of acid suppression achieved by different classes of drugs and perhaps between agents within those classes.https://www.termedia.pl/The-role-of-pH-in-symptomatic-relief-and-effective-treatment-of-gastroesophageal-reflux-disease,41,31240,1,1.htmlgastroesophageal reflux disease pH monitoring proton pump inhibitors |
| spellingShingle | Anita Gąsiorowska The role of pH in symptomatic relief and effective treatment of gastroesophageal reflux disease Gastroenterology Review gastroesophageal reflux disease pH monitoring proton pump inhibitors |
| title | The role of pH in symptomatic relief and effective treatment of gastroesophageal reflux disease |
| title_full | The role of pH in symptomatic relief and effective treatment of gastroesophageal reflux disease |
| title_fullStr | The role of pH in symptomatic relief and effective treatment of gastroesophageal reflux disease |
| title_full_unstemmed | The role of pH in symptomatic relief and effective treatment of gastroesophageal reflux disease |
| title_short | The role of pH in symptomatic relief and effective treatment of gastroesophageal reflux disease |
| title_sort | role of ph in symptomatic relief and effective treatment of gastroesophageal reflux disease |
| topic | gastroesophageal reflux disease pH monitoring proton pump inhibitors |
| url | https://www.termedia.pl/The-role-of-pH-in-symptomatic-relief-and-effective-treatment-of-gastroesophageal-reflux-disease,41,31240,1,1.html |
| work_keys_str_mv | AT anitagasiorowska theroleofphinsymptomaticreliefandeffectivetreatmentofgastroesophagealrefluxdisease AT anitagasiorowska roleofphinsymptomaticreliefandeffectivetreatmentofgastroesophagealrefluxdisease |