Best practices in the laboratory diagnosis, prognostication, prediction, and monitoring of Graves’ disease: role of TRAbs
Abstract Graves' disease (GD) is an autoimmune disorder characterized by activation of the TSH receptor by stimulatory autoantibodies (TSH Receptor Antibodies, or TRAbs), leading to unregulated thyroid hormone production. Diagnosis is largely based on the typical clinical picture and laboratory...
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BMC
2024-12-01
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| Series: | BMC Endocrine Disorders |
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| Online Access: | https://doi.org/10.1186/s12902-024-01809-9 |
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| author | Sanjay Kalra Shahjada Selim Dina Shrestha Noel Somasundaram Syed Abbas Raza Manash P. Baruah Saptarshi Bhattacharya Sharvil Gadve Ganapathi Bantwal Rakesh Sahay |
| author_facet | Sanjay Kalra Shahjada Selim Dina Shrestha Noel Somasundaram Syed Abbas Raza Manash P. Baruah Saptarshi Bhattacharya Sharvil Gadve Ganapathi Bantwal Rakesh Sahay |
| author_sort | Sanjay Kalra |
| collection | DOAJ |
| description | Abstract Graves' disease (GD) is an autoimmune disorder characterized by activation of the TSH receptor by stimulatory autoantibodies (TSH Receptor Antibodies, or TRAbs), leading to unregulated thyroid hormone production. Diagnosis is largely based on the typical clinical picture and laboratory thyroid panel. Establishment of elevated serum levels of TRAbs by competitive binding assay or cell-binding assay has its unique role in diagnosis and management of GD, especially in the differential diagnosis, therapy selection, prognostication, evaluation of thyroid function during pregnancy, peri-conceptional and neonatal thyroid workup, and in certain special situation. Inclusion of TRAbs in GD diagnostic algorithm can improve cost-effectiveness of GD management. The current best practice guidelines were developed to provide evidence-based recommendations in the use of TRABs in GD management for healthcare providers in South Asia. A panel of endocrinologists with minimum 10 years of clinical experience in thyroid disorders reviewed existing literature and their quality, and after deliberation and discussion, developed 21 recommendations surrounding the best practices surrounding the role of TRAbs in GD management. |
| format | Article |
| id | doaj-art-71a561f0f9b44f89a0653d0cd248821c |
| institution | Kabale University |
| issn | 1472-6823 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Endocrine Disorders |
| spelling | doaj-art-71a561f0f9b44f89a0653d0cd248821c2024-12-22T12:30:54ZengBMCBMC Endocrine Disorders1472-68232024-12-0124111210.1186/s12902-024-01809-9Best practices in the laboratory diagnosis, prognostication, prediction, and monitoring of Graves’ disease: role of TRAbsSanjay Kalra0Shahjada Selim1Dina Shrestha2Noel Somasundaram3Syed Abbas Raza4Manash P. Baruah5Saptarshi Bhattacharya6Sharvil Gadve7Ganapathi Bantwal8Rakesh Sahay9Bharti HospitalDepartment of Endocrinology, Bangabandhu Sheikh Mujib Medical University (BSMMU)Norvic International Hospital and Medical CollegeThe National Hospital of Sri LankaShaukat Khanum Cancer Hospital & Research CenterDiabetes, Endocrine & Metabolic Disease, Apollo Excelcare HospitalsEndocrinology and Diabetes, Indraprastha Apollo HospitalsExcel Endocrine CentreDepartment of Endocrinology, St. John’s Medical College & HospitalDepartment of Endocrinology, Osmania Medical College & Osmania General HospitalAbstract Graves' disease (GD) is an autoimmune disorder characterized by activation of the TSH receptor by stimulatory autoantibodies (TSH Receptor Antibodies, or TRAbs), leading to unregulated thyroid hormone production. Diagnosis is largely based on the typical clinical picture and laboratory thyroid panel. Establishment of elevated serum levels of TRAbs by competitive binding assay or cell-binding assay has its unique role in diagnosis and management of GD, especially in the differential diagnosis, therapy selection, prognostication, evaluation of thyroid function during pregnancy, peri-conceptional and neonatal thyroid workup, and in certain special situation. Inclusion of TRAbs in GD diagnostic algorithm can improve cost-effectiveness of GD management. The current best practice guidelines were developed to provide evidence-based recommendations in the use of TRABs in GD management for healthcare providers in South Asia. A panel of endocrinologists with minimum 10 years of clinical experience in thyroid disorders reviewed existing literature and their quality, and after deliberation and discussion, developed 21 recommendations surrounding the best practices surrounding the role of TRAbs in GD management.https://doi.org/10.1186/s12902-024-01809-9Graves’ diseaseTSH receptor antibodiesTRAbsSouth AsiaBest practicesDiagnosis |
| spellingShingle | Sanjay Kalra Shahjada Selim Dina Shrestha Noel Somasundaram Syed Abbas Raza Manash P. Baruah Saptarshi Bhattacharya Sharvil Gadve Ganapathi Bantwal Rakesh Sahay Best practices in the laboratory diagnosis, prognostication, prediction, and monitoring of Graves’ disease: role of TRAbs BMC Endocrine Disorders Graves’ disease TSH receptor antibodies TRAbs South Asia Best practices Diagnosis |
| title | Best practices in the laboratory diagnosis, prognostication, prediction, and monitoring of Graves’ disease: role of TRAbs |
| title_full | Best practices in the laboratory diagnosis, prognostication, prediction, and monitoring of Graves’ disease: role of TRAbs |
| title_fullStr | Best practices in the laboratory diagnosis, prognostication, prediction, and monitoring of Graves’ disease: role of TRAbs |
| title_full_unstemmed | Best practices in the laboratory diagnosis, prognostication, prediction, and monitoring of Graves’ disease: role of TRAbs |
| title_short | Best practices in the laboratory diagnosis, prognostication, prediction, and monitoring of Graves’ disease: role of TRAbs |
| title_sort | best practices in the laboratory diagnosis prognostication prediction and monitoring of graves disease role of trabs |
| topic | Graves’ disease TSH receptor antibodies TRAbs South Asia Best practices Diagnosis |
| url | https://doi.org/10.1186/s12902-024-01809-9 |
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