Tailoring cell-inspired biomaterials to fuel cancer therapy
Cancer stands as a predominant cause of mortality across the globe. Traditional cancer treatments, including surgery, radiotherapy, and chemotherapy, are effective yet face challenges like normal tissue damage, complications, and drug resistance. Biomaterials, with their advantages of high efficacy,...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-02-01
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| Series: | Materials Today Bio |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2590006424004423 |
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| author | Qi-Hui Wang Shi Cheng Chun-Yu Han Shuang Yang Sheng-Rui Gao Wan-Zhong Yin Wen-Zhi Song |
| author_facet | Qi-Hui Wang Shi Cheng Chun-Yu Han Shuang Yang Sheng-Rui Gao Wan-Zhong Yin Wen-Zhi Song |
| author_sort | Qi-Hui Wang |
| collection | DOAJ |
| description | Cancer stands as a predominant cause of mortality across the globe. Traditional cancer treatments, including surgery, radiotherapy, and chemotherapy, are effective yet face challenges like normal tissue damage, complications, and drug resistance. Biomaterials, with their advantages of high efficacy, targeting, and spatiotemporal controllability, have been widely used in cancer treatment. However, the biocompatibility limitations of traditional synthetic materials have restricted their clinical translation and application. Natural cell-inspired biomaterials inherently possess the targeting abilities of cells, biocompatibility, and immune evasion capabilities. Therefore, cell-inspired biomaterials can be used alone or in combination with other drugs or treatment strategies for cancer therapy. In this review, we first introduce the timeline of key milestones in cell-inspired biomaterials for cancer therapy. Then, we describe the abnormalities in cancer including biophysics, cellular biology, and molecular biology aspects. Afterwards, we summarize the design strategies of cell-inspired antitumor biomaterials. Subsequently, we elaborate on the application of antitumor biomaterials inspired by various cell types. Finally, we explore the current challenges and prospects of cell-inspired antitumor materials. This review aims to provide new opportunities and references for the development of antitumor cell-inspired biomaterials. |
| format | Article |
| id | doaj-art-71838dc3681b4b8ba82e3a7f7d4c80dc |
| institution | Kabale University |
| issn | 2590-0064 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Materials Today Bio |
| spelling | doaj-art-71838dc3681b4b8ba82e3a7f7d4c80dc2025-01-17T04:52:02ZengElsevierMaterials Today Bio2590-00642025-02-0130101381Tailoring cell-inspired biomaterials to fuel cancer therapyQi-Hui Wang0Shi Cheng1Chun-Yu Han2Shuang Yang3Sheng-Rui Gao4Wan-Zhong Yin5Wen-Zhi Song6Department of Stomatology, China-Japan Union Hospital, Jilin University, 126#Xiantai Street, Jingkai District, Changchun, 130031, PR ChinaState Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School & Hospital of Stomatology, Wuhan University, Wuhan, 430079, PR ChinaDepartment of Stomatology, China-Japan Union Hospital, Jilin University, 126#Xiantai Street, Jingkai District, Changchun, 130031, PR ChinaDepartment of Stomatology, China-Japan Union Hospital, Jilin University, 126#Xiantai Street, Jingkai District, Changchun, 130031, PR ChinaDepartment of Otorhinolaryngology, Head and Neck Surgery, The First Hospital of Jilin University, Changchun, 130061, PR ChinaDepartment of Otorhinolaryngology, Head and Neck Surgery, The First Hospital of Jilin University, Changchun, 130061, PR China; Corresponding author.Department of Stomatology, China-Japan Union Hospital, Jilin University, 126#Xiantai Street, Jingkai District, Changchun, 130031, PR China; Corresponding author.Cancer stands as a predominant cause of mortality across the globe. Traditional cancer treatments, including surgery, radiotherapy, and chemotherapy, are effective yet face challenges like normal tissue damage, complications, and drug resistance. Biomaterials, with their advantages of high efficacy, targeting, and spatiotemporal controllability, have been widely used in cancer treatment. However, the biocompatibility limitations of traditional synthetic materials have restricted their clinical translation and application. Natural cell-inspired biomaterials inherently possess the targeting abilities of cells, biocompatibility, and immune evasion capabilities. Therefore, cell-inspired biomaterials can be used alone or in combination with other drugs or treatment strategies for cancer therapy. In this review, we first introduce the timeline of key milestones in cell-inspired biomaterials for cancer therapy. Then, we describe the abnormalities in cancer including biophysics, cellular biology, and molecular biology aspects. Afterwards, we summarize the design strategies of cell-inspired antitumor biomaterials. Subsequently, we elaborate on the application of antitumor biomaterials inspired by various cell types. Finally, we explore the current challenges and prospects of cell-inspired antitumor materials. This review aims to provide new opportunities and references for the development of antitumor cell-inspired biomaterials.http://www.sciencedirect.com/science/article/pii/S2590006424004423Cell-inspiredBiomaterialsCancer therapy |
| spellingShingle | Qi-Hui Wang Shi Cheng Chun-Yu Han Shuang Yang Sheng-Rui Gao Wan-Zhong Yin Wen-Zhi Song Tailoring cell-inspired biomaterials to fuel cancer therapy Materials Today Bio Cell-inspired Biomaterials Cancer therapy |
| title | Tailoring cell-inspired biomaterials to fuel cancer therapy |
| title_full | Tailoring cell-inspired biomaterials to fuel cancer therapy |
| title_fullStr | Tailoring cell-inspired biomaterials to fuel cancer therapy |
| title_full_unstemmed | Tailoring cell-inspired biomaterials to fuel cancer therapy |
| title_short | Tailoring cell-inspired biomaterials to fuel cancer therapy |
| title_sort | tailoring cell inspired biomaterials to fuel cancer therapy |
| topic | Cell-inspired Biomaterials Cancer therapy |
| url | http://www.sciencedirect.com/science/article/pii/S2590006424004423 |
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