Role of endoscopic submucosal dissection in treatment of rectal gastroenteropancreatic neuroendocrine neoplasms
Introduction : A significant rise in incidence of rectal gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs) has been observed in the last decade. Most detected gastroenteropancreatic neuroendocrine tumors (GEP-NETs) are well differentiated and less than 2 cm in diameter. Endoscopic submucosa...
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Termedia Publishing House
2016-12-01
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| Series: | Gastroenterology Review |
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| Online Access: | https://www.termedia.pl/Role-of-endoscopic-submucosal-dissection-in-treatment-of-rectal-gastroenteropancreatic-neuroendocrine-neoplasms,41,28913,1,1.html |
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| author | Michał Spychalski Włodzimierz Koptas Piotr Zelga Adam Dziki |
| author_facet | Michał Spychalski Włodzimierz Koptas Piotr Zelga Adam Dziki |
| author_sort | Michał Spychalski |
| collection | DOAJ |
| description | Introduction : A significant rise in incidence of rectal gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs) has been observed in the last decade. Most detected gastroenteropancreatic neuroendocrine tumors (GEP-NETs) are well differentiated and less than 2 cm in diameter. Endoscopic submucosal dissection (ESD) is a new method for endoscopic treatment of such tumors, difficult to resect by conventional endoscopic techniques and thus subject to surgical treatment.
Aim: To present the results of the endoscopic treatment of GEP NET tumors in the rectum using ESD in single academic center.
Material and methods : From June 2013 to April 2014, 4 cases of GEP-NET in the rectum were treated by ESD in our center. Effectiveness of dissection, complications and tumor recurrence after 3 months of treatment were then retrospectively investigated.
Results : The group contained 2 patients with primary rectal GEP-NET (1 male, 1 female; age range: 48–60 years) and 2 with scars after incomplete polypectomy of rectal GEP-NET (1 male, 1 female; 61–65 years). Primary rectal GEP-NET diameters were 0.6 cm and 1.5 cm. Scar resection specimen diameters were 0.7 cm and 1 cm. Mean resection time was 28 min. The en bloc resection rate was 100% (2 of 2) and the histologically complete resection was confirmed in both cases. No foci of neuroendocrine neoplasia were reported in dissected scars. No complications were observed. After 3 months, 3 patients underwent follow-up colonoscopy – no local recurrence was reported.
Conclusions : Endoscopic submucosal dissection of rectal GEP-NET should be recommended as a treatment of choice when dealing with lesions over 1 cm in diameter without invasion of the muscle layer. Due to technical difficulties, performing this procedure should be reserved for centers with appropriately trained endoscopic staff. |
| format | Article |
| id | doaj-art-7175467be47f414c92bd81624f90b53d |
| institution | Kabale University |
| issn | 1895-5770 1897-4317 |
| language | English |
| publishDate | 2016-12-01 |
| publisher | Termedia Publishing House |
| record_format | Article |
| series | Gastroenterology Review |
| spelling | doaj-art-7175467be47f414c92bd81624f90b53d2025-01-10T14:06:16ZengTermedia Publishing HouseGastroenterology Review1895-57701897-43172016-12-01121172110.5114/pg.2016.6463528913Role of endoscopic submucosal dissection in treatment of rectal gastroenteropancreatic neuroendocrine neoplasmsMichał SpychalskiWłodzimierz KoptasPiotr ZelgaAdam DzikiIntroduction : A significant rise in incidence of rectal gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs) has been observed in the last decade. Most detected gastroenteropancreatic neuroendocrine tumors (GEP-NETs) are well differentiated and less than 2 cm in diameter. Endoscopic submucosal dissection (ESD) is a new method for endoscopic treatment of such tumors, difficult to resect by conventional endoscopic techniques and thus subject to surgical treatment. Aim: To present the results of the endoscopic treatment of GEP NET tumors in the rectum using ESD in single academic center. Material and methods : From June 2013 to April 2014, 4 cases of GEP-NET in the rectum were treated by ESD in our center. Effectiveness of dissection, complications and tumor recurrence after 3 months of treatment were then retrospectively investigated. Results : The group contained 2 patients with primary rectal GEP-NET (1 male, 1 female; age range: 48–60 years) and 2 with scars after incomplete polypectomy of rectal GEP-NET (1 male, 1 female; 61–65 years). Primary rectal GEP-NET diameters were 0.6 cm and 1.5 cm. Scar resection specimen diameters were 0.7 cm and 1 cm. Mean resection time was 28 min. The en bloc resection rate was 100% (2 of 2) and the histologically complete resection was confirmed in both cases. No foci of neuroendocrine neoplasia were reported in dissected scars. No complications were observed. After 3 months, 3 patients underwent follow-up colonoscopy – no local recurrence was reported. Conclusions : Endoscopic submucosal dissection of rectal GEP-NET should be recommended as a treatment of choice when dealing with lesions over 1 cm in diameter without invasion of the muscle layer. Due to technical difficulties, performing this procedure should be reserved for centers with appropriately trained endoscopic staff.https://www.termedia.pl/Role-of-endoscopic-submucosal-dissection-in-treatment-of-rectal-gastroenteropancreatic-neuroendocrine-neoplasms,41,28913,1,1.htmlendoscopic submucosal dissection gastroenteropancreatic neuroendocrine tumors colorectal |
| spellingShingle | Michał Spychalski Włodzimierz Koptas Piotr Zelga Adam Dziki Role of endoscopic submucosal dissection in treatment of rectal gastroenteropancreatic neuroendocrine neoplasms Gastroenterology Review endoscopic submucosal dissection gastroenteropancreatic neuroendocrine tumors colorectal |
| title | Role of endoscopic submucosal dissection in treatment of rectal gastroenteropancreatic neuroendocrine neoplasms |
| title_full | Role of endoscopic submucosal dissection in treatment of rectal gastroenteropancreatic neuroendocrine neoplasms |
| title_fullStr | Role of endoscopic submucosal dissection in treatment of rectal gastroenteropancreatic neuroendocrine neoplasms |
| title_full_unstemmed | Role of endoscopic submucosal dissection in treatment of rectal gastroenteropancreatic neuroendocrine neoplasms |
| title_short | Role of endoscopic submucosal dissection in treatment of rectal gastroenteropancreatic neuroendocrine neoplasms |
| title_sort | role of endoscopic submucosal dissection in treatment of rectal gastroenteropancreatic neuroendocrine neoplasms |
| topic | endoscopic submucosal dissection gastroenteropancreatic neuroendocrine tumors colorectal |
| url | https://www.termedia.pl/Role-of-endoscopic-submucosal-dissection-in-treatment-of-rectal-gastroenteropancreatic-neuroendocrine-neoplasms,41,28913,1,1.html |
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