Lowering blood pressure after acute intracerebral haemorrhage: protocol for a systematic review and meta-analysis using individual patient data from randomised controlled trials participating in the Blood Pressure in Acute Stroke Collaboration (BASC)
Introduction Conflicting results from multiple randomised trials indicate that the methods and effects of blood pressure (BP) reduction after acute intracerebral haemorrhage (ICH) are complex. The Blood pressure in Acute Stroke Collaboration is an international collaboration, which aims to determine...
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BMJ Publishing Group
2019-07-01
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| Online Access: | https://bmjopen.bmj.com/content/9/7/e030121.full |
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| author | Keith W Muir Gary Ford Philip M Bath Adnan I Qureshi Thompson G Robinson Rustam Al-Shahi Salman Hisatomi Arima Lisa J Woodhouse Eivind Berge Nikola Sprigg Xia Wang Tom J Moullaali Zhe Kang Law Candice Delcourt Kailash Krishnan Else C Sandset Craig S Anderson Yuko Palesch John Potter Jeff Saver Nerses Sanossian Ken Butcher Kennedy R Lees Janneke Horn |
| author_facet | Keith W Muir Gary Ford Philip M Bath Adnan I Qureshi Thompson G Robinson Rustam Al-Shahi Salman Hisatomi Arima Lisa J Woodhouse Eivind Berge Nikola Sprigg Xia Wang Tom J Moullaali Zhe Kang Law Candice Delcourt Kailash Krishnan Else C Sandset Craig S Anderson Yuko Palesch John Potter Jeff Saver Nerses Sanossian Ken Butcher Kennedy R Lees Janneke Horn |
| author_sort | Keith W Muir |
| collection | DOAJ |
| description | Introduction Conflicting results from multiple randomised trials indicate that the methods and effects of blood pressure (BP) reduction after acute intracerebral haemorrhage (ICH) are complex. The Blood pressure in Acute Stroke Collaboration is an international collaboration, which aims to determine the optimal management of BP after acute stroke including ICH.Methods and analysis A systematic review will be undertaken according to the Preferred Reporting Items for Systematic review and Meta-Analysis of Individual Participant Data (IPD) guideline. A search of Cochrane Central Register of Controlled Trials, EMBASE and MEDLINE from inception will be conducted to identify randomised controlled trials of BP management in adults with acute spontaneous (non-traumatic) ICH enrolled within the first 7 days of symptom onset. Authors of studies that meet the inclusion criteria will be invited to share their IPD. The primary outcome will be functional outcome according to the modified Rankin Scale. Safety outcomes will be early neurological deterioration, symptomatic hypotension and serious adverse events. Secondary outcomes will include death and neuroradiological and haemodynamic variables. Meta-analyses of pooled IPD using the intention-to-treat dataset of included trials, including subgroup analyses to assess modification of the effects of BP lowering by time to treatment, treatment strategy and patient’s demographic, clinical and prestroke neuroradiological characteristics.Ethics and dissemination No new patient data will be collected nor is there any deviation from the original purposes of each study where ethical approvals were granted; therefore, further ethical approval is not required. Results will be reported in international peer-reviewed journals.PROSPERO registration number CRD42019141136. |
| format | Article |
| id | doaj-art-716c07f1051c41daaaa9cea12bdad31f |
| institution | Kabale University |
| issn | 2044-6055 |
| language | English |
| publishDate | 2019-07-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open |
| spelling | doaj-art-716c07f1051c41daaaa9cea12bdad31f2024-11-22T20:55:09ZengBMJ Publishing GroupBMJ Open2044-60552019-07-019710.1136/bmjopen-2019-030121Lowering blood pressure after acute intracerebral haemorrhage: protocol for a systematic review and meta-analysis using individual patient data from randomised controlled trials participating in the Blood Pressure in Acute Stroke Collaboration (BASC)Keith W Muir0Gary Ford1Philip M Bath2Adnan I Qureshi3Thompson G Robinson4Rustam Al-Shahi Salman5Hisatomi Arima6Lisa J Woodhouse7Eivind Berge8Nikola Sprigg9Xia Wang10Tom J Moullaali11Zhe Kang Law12Candice Delcourt13Kailash Krishnan14Else C Sandset15Craig S Anderson16Yuko PaleschJohn Potter17Jeff SaverNerses SanossianKen Butcher18Kennedy R Lees19Janneke Horn20School of Psychology and Neuroscience, University of Glasgow, Glasgow, UK5Health Science Networks, Oxford University Hospitals, UK4 Stroke Trials Unit, Division of Clinical Neuroscience, University of Nottingham, Nottingham, Nottinghamshire, UK3 Zeenat Qureshi Stroke Institute and Department of Neurology, University of Missouri, Columbia, Missouri, USA1Cerebral Haemodynamics in Ageing and Stroke Medicine (CHiASM) Research Group, Department of Cardiovascular Sciences, University of Leicester, UK3 Edinburgh Clinical Trials Unit, The University of Edinburgh, Edinburgh, UKDepartment of Preventive Medicine and Public Health, Faculty of Medicine, Fukuoka University, Fukuoka, Japan1 Stroke, Division of Clinical Neurosciences, University of Nottingham, Nottingham, UK4 Department of Internal Medicine and Cardiology, Oslo University Hospital, Oslo, Norway1 Stroke, Division of Clinical Neurosciences, University of Nottingham, Nottingham, UKDepartment of Rheumatology, Royal North Shore Hospital, Northern Clinical School, Faculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, AustraliaThe George Institute for Global Health, Faculty of Medicine, University of New South Wales, Sydney, New South Wales, AustraliaStroke Trials Unit, Mental Health and Clinical Neurosciences, University of Nottingham, Nottingham, UKDepartment of Clinical Medicine, Faculty of Medicine, Health and Human Sciences, Macquarie University, Sydney, New South Wales, AustraliaStroke, Nottingham University Hospitals NHS Trust, Nottingham, UKDepartment of Neurology, Oslo University Hospital, Oslo, NorwayGlobal Brain Health Program, The George Institute for Global Health, University of New South Wales, Sydney, New South Wales, AustraliaStroke Research Group, Norfolk and Norwich University Hospital, UKDepartment of Neurology, Liverpool Hospital, Ingham Institute for Applied Medical Research, University of New South Wales South Western Sydney Clinical School, Liverpool, New South Wales, Australiaprofessor of cerebrovascular medicineAmsterdam Neuroscience - Brain Imaging, Amsterdam, The NetherlandsIntroduction Conflicting results from multiple randomised trials indicate that the methods and effects of blood pressure (BP) reduction after acute intracerebral haemorrhage (ICH) are complex. The Blood pressure in Acute Stroke Collaboration is an international collaboration, which aims to determine the optimal management of BP after acute stroke including ICH.Methods and analysis A systematic review will be undertaken according to the Preferred Reporting Items for Systematic review and Meta-Analysis of Individual Participant Data (IPD) guideline. A search of Cochrane Central Register of Controlled Trials, EMBASE and MEDLINE from inception will be conducted to identify randomised controlled trials of BP management in adults with acute spontaneous (non-traumatic) ICH enrolled within the first 7 days of symptom onset. Authors of studies that meet the inclusion criteria will be invited to share their IPD. The primary outcome will be functional outcome according to the modified Rankin Scale. Safety outcomes will be early neurological deterioration, symptomatic hypotension and serious adverse events. Secondary outcomes will include death and neuroradiological and haemodynamic variables. Meta-analyses of pooled IPD using the intention-to-treat dataset of included trials, including subgroup analyses to assess modification of the effects of BP lowering by time to treatment, treatment strategy and patient’s demographic, clinical and prestroke neuroradiological characteristics.Ethics and dissemination No new patient data will be collected nor is there any deviation from the original purposes of each study where ethical approvals were granted; therefore, further ethical approval is not required. Results will be reported in international peer-reviewed journals.PROSPERO registration number CRD42019141136.https://bmjopen.bmj.com/content/9/7/e030121.full |
| spellingShingle | Keith W Muir Gary Ford Philip M Bath Adnan I Qureshi Thompson G Robinson Rustam Al-Shahi Salman Hisatomi Arima Lisa J Woodhouse Eivind Berge Nikola Sprigg Xia Wang Tom J Moullaali Zhe Kang Law Candice Delcourt Kailash Krishnan Else C Sandset Craig S Anderson Yuko Palesch John Potter Jeff Saver Nerses Sanossian Ken Butcher Kennedy R Lees Janneke Horn Lowering blood pressure after acute intracerebral haemorrhage: protocol for a systematic review and meta-analysis using individual patient data from randomised controlled trials participating in the Blood Pressure in Acute Stroke Collaboration (BASC) BMJ Open |
| title | Lowering blood pressure after acute intracerebral haemorrhage: protocol for a systematic review and meta-analysis using individual patient data from randomised controlled trials participating in the Blood Pressure in Acute Stroke Collaboration (BASC) |
| title_full | Lowering blood pressure after acute intracerebral haemorrhage: protocol for a systematic review and meta-analysis using individual patient data from randomised controlled trials participating in the Blood Pressure in Acute Stroke Collaboration (BASC) |
| title_fullStr | Lowering blood pressure after acute intracerebral haemorrhage: protocol for a systematic review and meta-analysis using individual patient data from randomised controlled trials participating in the Blood Pressure in Acute Stroke Collaboration (BASC) |
| title_full_unstemmed | Lowering blood pressure after acute intracerebral haemorrhage: protocol for a systematic review and meta-analysis using individual patient data from randomised controlled trials participating in the Blood Pressure in Acute Stroke Collaboration (BASC) |
| title_short | Lowering blood pressure after acute intracerebral haemorrhage: protocol for a systematic review and meta-analysis using individual patient data from randomised controlled trials participating in the Blood Pressure in Acute Stroke Collaboration (BASC) |
| title_sort | lowering blood pressure after acute intracerebral haemorrhage protocol for a systematic review and meta analysis using individual patient data from randomised controlled trials participating in the blood pressure in acute stroke collaboration basc |
| url | https://bmjopen.bmj.com/content/9/7/e030121.full |
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