Quercetin Alleviates Hyperglycemic-Generated Endoplasmic Reticulum Stress-Contacted Apoptosis of Rat Nucleus Pulposus Cells

Quercetin Alleviates Hyperglycemic-Generated Endoplasmic Reticulum Stress-Contacted Apoptosis of Rat Nucleus Pulposus Cells

Background: Previous research has shown that apoptosis of nucleus pulposus (NP) cells contributes to intervertebral disc degeneration (IDD) progression. Endoplasmic reticulum (ER) stress is a reaction to diverse stimuli in eukaryotes and is tightly contacted with apoptosis. Quercetin, a naturally oc...

Full description

Saved in:

Bibliographic Details
Main Authors:	Zhen Yu, Xianfeng Wang, Yusen Hu, Xinfa Wang, Zhenghuan Zhu, Xu Xu, Yiming Wang, Ailiang Zhang
Format:	Article
Language:	English
Published:	Galenos Publishing House 2025-01-01
Series:	Balkan Medical Journal
Online Access:	https://balkanmedicaljournal.org/abstract.php?id=2668
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Goose astrovirus induces apoptosis and endoplasmic reticulum stress in gosling hepatocytes
by: Zhihua Lu, et al.
Published: (2025-01-01)

Rutin Alleviates Zearalenone-Induced Endoplasmic Reticulum Stress and Mitochondrial Pathway Apoptosis in Porcine Endometrial Stromal Cells by Promoting the Expression of Nrf2
by: Chuangjiang Chen, et al.
Published: (2024-12-01)

DPSCs Protect Architectural Integrity and Alleviate Intervertebral Disc Degeneration by Regulating Nucleus Pulposus Immune Status
by: Xiwen Dong, et al.
Published: (2022-01-01)

Nucleus Pulposus Cell Conditioned Medium Promotes Mesenchymal Stem Cell Differentiation into Nucleus Pulposus-Like Cells under Hypoxic Conditions
by: Arjun Sinkemani, et al.
Published: (2020-01-01)

Effects of Duhuo Jisheng Decoction on Calcium Homeostasis and Apoptosis of Chondrocytes under Endoplasmic Reticulum Stress
by: Qing LIN, et al.
Published: (2020-12-01)

Endoplasmic Reticulum Is at the Crossroads of Autophagy, Inflammation, and Apoptosis Signaling Pathways and Participates in the Pathogenesis of Diabetes Mellitus
by: Jing Su, et al.
Published: (2013-01-01)

Endoplasmic reticulum stress improved chicken tenderness, promoted apoptosis and autophagy during postmortem ageing
by: Yuwei Chai, et al.
Published: (2024-07-01)

Nucleus pulposus cell network modelling in the intervertebral disc
by: Sofia Tseranidou, et al.
Published: (2025-01-01)

Mesenchymal Stem Cells May Alleviate the Intervertebral Disc Degeneration by Reducing the Oxidative Stress in Nucleus Pulposus Cells
by: Yongzhao Zhao, et al.
Published: (2022-01-01)

mTOR Modulates the Endoplasmic Reticulum Stress-Induced CD4+ T Cell Apoptosis Mediated by ROS in Septic Immunosuppression
by: Hao Wang, et al.
Published: (2022-01-01)

Cancer Microenvironment and Endoplasmic Reticulum Stress Response
by: Claudia Giampietri, et al.
Published: (2015-01-01)

Proteomic Analysis of Rough and Smooth Endoplasmic Reticulum
by: Jacques Paiement, et al.
Published: (2002-01-01)

Remodeling of Mitochondria–Endoplasmic Reticulum Contact Sites Accompanies LUHMES Differentiation
by: Emad Norouzi Esfahani, et al.
Published: (2025-01-01)

Curcumin Improves Epithelial Barrier Integrity of Caco-2 Monolayers by Inhibiting Endoplasmic Reticulum Stress and Subsequent Apoptosis
by: Xinxin Zhou, et al.
Published: (2021-01-01)

Inverse Agonist of Retinoid-Related Orphan Receptor-Alpha Prevents Apoptosis and Degeneration in Nucleus Pulposus Cells via Upregulation of YAP
by: Tongzhou Liang, et al.
Published: (2021-01-01)

Retracted: Effect of Fas and Bcl-2 DNA Damages Response Expression in Stem Cells on Apoptosis of Nucleus Pulposus of Intervertebral Disc
by: Stem Cells International
Published: (2024-01-01)

Research progress of endoplasmic reticulum stress in peritoneal dialysis
by: Li Yan-ling, et al.
Published: (2025-01-01)

Clinical characteristics associated with cervical hydrated nucleus pulposus extrusion in dogs
by: Megan Lin, et al.
Published: (2025-01-01)

Targeting endoplasmic reticulum stress: an innovative therapeutic strategy for podocyte-related kidney diseases
by: Jiao Lv, et al.
Published: (2025-01-01)

Age-Related Changes in Nucleus Pulposus Mesenchymal Stem Cells: An In Vitro Study in Rats
by: Yachao Zhao, et al.
Published: (2017-01-01)

Effect of Compression Loading on Human Nucleus Pulposus-Derived Mesenchymal Stem Cells
by: Hang Liang, et al.
Published: (2018-01-01)

PDE4B promotes ferroptosis in nucleus pulposus cells and is involved in intervertebral disc degeneration
by: Weixing Xu, et al.
Published: (2025-02-01)

Mechanisms of Alcohol-Induced Endoplasmic Reticulum Stress and Organ Injuries
by: Cheng Ji
Published: (2012-01-01)

MANF overexpression ameliorates oxidative stress-induced apoptosis of human nucleus pulposus cells by facilitating mitophagy through promoting MFN2 expression
by: Liang Ma, et al.
Published: (2025-01-01)

Effects of Changes in Osmolarity on the Biological Activity of Human Normal Nucleus Pulposus Mesenchymal Stem Cells
by: Hua Zhang, et al.
Published: (2022-01-01)

Aloin Regulates Matrix Metabolism and Apoptosis in Human Nucleus Pulposus Cells via the TAK1/NF-κB/NLRP3 Signaling Pathway
by: Taiqiu Chen, et al.
Published: (2022-01-01)

Mitochondria-Associated Endoplasmic Reticulum Membranes in Microglia: One Contact Site to Rule Them all
by: Elisa Navarro, et al.
Published: (2025-01-01)

Endoplasmic Reticulum Stress: Its Role in Disease and Novel Prospects for Therapy
by: Axel H. Schönthal
Published: (2012-01-01)

Gallic acid showed neuroprotection against endoplasmic reticulum stress in rats
by: Abdulmutalip Karaaslanlı, et al.
Published: (2025-01-01)

Sestrin2 Overexpression Ameliorates Endoplasmic Reticulum Stress-Induced Apoptosis via Inhibiting mTOR Pathway in HepG2 Cells
by: Huiling Hu, et al.
Published: (2022-01-01)

High Concentration of Glucose Increases Reactive Oxygen Species Generation and Apoptosis Induced by Endoplasmic Reticulum Stress Pathway in Rabbit Corneal Epithelial Cells
by: Jiajun Lu, et al.
Published: (2018-01-01)

The Upregulation of COX2 in Human Degenerated Nucleus Pulposus: The Association of Inflammation with Intervertebral Disc Degeneration
by: Chang Liu, et al.
Published: (2021-01-01)

Fibrocyte enrichment and myofibroblastic adaptation causes nucleus pulposus fibrosis and associates with disc degeneration severity
by: Yi Sun, et al.
Published: (2025-01-01)

Role of Mitochondria-Associated Endoplasmic Reticulum Membrane in Inflammation-Mediated Metabolic Diseases
by: Themis Thoudam, et al.
Published: (2016-01-01)

Endoplasmic Reticulum Chaperon Tauroursodeoxycholic Acid Attenuates Aldosterone-Infused Renal Injury
by: Honglei Guo, et al.
Published: (2016-01-01)

Endoplasmic Reticulum Stress in Intestinal Epithelial Cell Function and Inflammatory Bowel Disease
by: Katherine Luo, et al.
Published: (2015-01-01)

Endoplasmic Reticulum Stress-Associated Lipid Droplet Formation and Type II Diabetes
by: Xuebao Zhang, et al.
Published: (2012-01-01)

Identification of critical endoplasmic reticulum stress-related genes in advanced atherosclerotic plaque
by: Ning Zhao, et al.
Published: (2025-01-01)

High Glucose-Induced Oxidative Stress Mediates Apoptosis and Extracellular Matrix Metabolic Imbalances Possibly via p38 MAPK Activation in Rat Nucleus Pulposus Cells
by: Xiaofei Cheng, et al.
Published: (2016-01-01)

Therapeutic potential of targeting the IRF2/POSTN/Notch1 axis in nucleus pulposus cells for intervertebral disc degeneration
by: Daxue Zhu, et al.
Published: (2025-01-01)