SLC7A5 is required for cancer cell growth under arginine-limited conditions

SLC7A5 is required for cancer cell growth under arginine-limited conditions

Summary: Tumor cells must optimize metabolite acquisition between synthesis and uptake from a microenvironment characterized by hypoxia, lactate accumulation, and depletion of many amino acids, including arginine. We performed a metabolism-focused functional screen using CRISPR-Cas9 to identify path...

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Bibliographic Details
Main Authors: Kyle N. Dunlap, Austin Bender, Alexis Bowles, Alex J. Bott, Joshua Tay, Allie H. Grossmann, Jared Rutter, Gregory S. Ducker
Format: Article
Language:English
Published: Elsevier 2025-01-01
Series:Cell Reports
Subjects:
CP: Cancer
CP: Metabolism
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124724014815
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