Comparison of dexmedetomidine and clonidine as an adjuvant to lignocaine with adrenaline in infiltration anesthesia in tympanoplasty: A randomized controlled trial
Background: Recent trends in surgical practice involve using local anesthesia for procedures like middle ear tympanoplasty due to its benefits, but patients often experience discomfort. Researchers are investigating alpha-2 agonists like clonidine and dexmedetomidine to enhance pain relief. We condu...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2024-12-01
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| Series: | The Indian Anaesthetists' Forum |
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| Online Access: | https://journals.lww.com/10.4103/TheIAForum.TheIAForum_123_23 |
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| author | Veena Mathur Pradeep Kumar Sonam Mittal Deepika Meena Maina Singh Veena Patodi |
| author_facet | Veena Mathur Pradeep Kumar Sonam Mittal Deepika Meena Maina Singh Veena Patodi |
| author_sort | Veena Mathur |
| collection | DOAJ |
| description | Background:
Recent trends in surgical practice involve using local anesthesia for procedures like middle ear tympanoplasty due to its benefits, but patients often experience discomfort. Researchers are investigating alpha-2 agonists like clonidine and dexmedetomidine to enhance pain relief. We conducted a double-blind study comparing dexmedetomidine and clonidine’s effectiveness in extending pain relief after tympanoplasty using local infiltration.
Aim and Objective:
In light of this context, we undertook a randomized, double-blind investigation to compare the efficacy of dexmedetomidine and clonidine in extending the duration of pain relief via local infiltration for tympanoplasty.
Materials and Methods:
This prospective, randomized, double-blind study was conducted on total of 60 patients belonging to the American Society of Anesthesiologists Class I and II scheduled for tympanoplasty under local anesthesia. All patients were divided into two groups: Group LC, received local infiltration with 12 mL of lignocaine (2%) with adrenaline (1:200,000) plus clonidine (1 μg/kg) and Group LD, received local infiltration with 12 mL of lignocaine (2%) with adrenaline (1:200,000) plus dexmedetomidine (1 μg/kg).
Results:
Both the groups were comparable regarding demographic profile, perioperative hemodynamics, and total duration of surgery. Time of onset of analgesia was faster in Group LD (89.53 ± 5.54 vs. 94.17 ± 6.19 s) (P = 0.0034) and total duration of analgesia was also prolonged in Group LD (562.40 ± 24.82 vs. 332.30 ± 12.39 min) (P < 0.0001).
Conclusion:
We concluded that in comparison to clonidine, dexmedetomidine is more effective in terms of faster onset and prolongation of total duration of analgesia when used with local infiltration anesthesia. |
| format | Article |
| id | doaj-art-71601be432ff4f5ea87108b841944b34 |
| institution | Kabale University |
| issn | 0973-0311 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | The Indian Anaesthetists' Forum |
| spelling | doaj-art-71601be432ff4f5ea87108b841944b342025-01-07T05:53:40ZengWolters Kluwer Medknow PublicationsThe Indian Anaesthetists' Forum0973-03112024-12-01252798510.4103/TheIAForum.TheIAForum_123_23Comparison of dexmedetomidine and clonidine as an adjuvant to lignocaine with adrenaline in infiltration anesthesia in tympanoplasty: A randomized controlled trialVeena MathurPradeep KumarSonam MittalDeepika MeenaMaina SinghVeena PatodiBackground: Recent trends in surgical practice involve using local anesthesia for procedures like middle ear tympanoplasty due to its benefits, but patients often experience discomfort. Researchers are investigating alpha-2 agonists like clonidine and dexmedetomidine to enhance pain relief. We conducted a double-blind study comparing dexmedetomidine and clonidine’s effectiveness in extending pain relief after tympanoplasty using local infiltration. Aim and Objective: In light of this context, we undertook a randomized, double-blind investigation to compare the efficacy of dexmedetomidine and clonidine in extending the duration of pain relief via local infiltration for tympanoplasty. Materials and Methods: This prospective, randomized, double-blind study was conducted on total of 60 patients belonging to the American Society of Anesthesiologists Class I and II scheduled for tympanoplasty under local anesthesia. All patients were divided into two groups: Group LC, received local infiltration with 12 mL of lignocaine (2%) with adrenaline (1:200,000) plus clonidine (1 μg/kg) and Group LD, received local infiltration with 12 mL of lignocaine (2%) with adrenaline (1:200,000) plus dexmedetomidine (1 μg/kg). Results: Both the groups were comparable regarding demographic profile, perioperative hemodynamics, and total duration of surgery. Time of onset of analgesia was faster in Group LD (89.53 ± 5.54 vs. 94.17 ± 6.19 s) (P = 0.0034) and total duration of analgesia was also prolonged in Group LD (562.40 ± 24.82 vs. 332.30 ± 12.39 min) (P < 0.0001). Conclusion: We concluded that in comparison to clonidine, dexmedetomidine is more effective in terms of faster onset and prolongation of total duration of analgesia when used with local infiltration anesthesia.https://journals.lww.com/10.4103/TheIAForum.TheIAForum_123_23clonidinedexmedetomidinelocal infiltrationmonitored anesthesia care |
| spellingShingle | Veena Mathur Pradeep Kumar Sonam Mittal Deepika Meena Maina Singh Veena Patodi Comparison of dexmedetomidine and clonidine as an adjuvant to lignocaine with adrenaline in infiltration anesthesia in tympanoplasty: A randomized controlled trial The Indian Anaesthetists' Forum clonidine dexmedetomidine local infiltration monitored anesthesia care |
| title | Comparison of dexmedetomidine and clonidine as an adjuvant to lignocaine with adrenaline in infiltration anesthesia in tympanoplasty: A randomized controlled trial |
| title_full | Comparison of dexmedetomidine and clonidine as an adjuvant to lignocaine with adrenaline in infiltration anesthesia in tympanoplasty: A randomized controlled trial |
| title_fullStr | Comparison of dexmedetomidine and clonidine as an adjuvant to lignocaine with adrenaline in infiltration anesthesia in tympanoplasty: A randomized controlled trial |
| title_full_unstemmed | Comparison of dexmedetomidine and clonidine as an adjuvant to lignocaine with adrenaline in infiltration anesthesia in tympanoplasty: A randomized controlled trial |
| title_short | Comparison of dexmedetomidine and clonidine as an adjuvant to lignocaine with adrenaline in infiltration anesthesia in tympanoplasty: A randomized controlled trial |
| title_sort | comparison of dexmedetomidine and clonidine as an adjuvant to lignocaine with adrenaline in infiltration anesthesia in tympanoplasty a randomized controlled trial |
| topic | clonidine dexmedetomidine local infiltration monitored anesthesia care |
| url | https://journals.lww.com/10.4103/TheIAForum.TheIAForum_123_23 |
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