Associations of reverse triiodothyronine serum levels with anxiety, depression, and health related quality of life after experiencing acute ischemic stroke
AimThis study intended to explore associations of reverse triiodothyronine (rT3) with emotional disturbances and health-related quality of life (HRQoL) after experiencing acute ischemic stroke (AIS).Materials and methodsSerum samples from individuals with AIS were collected on admission to three Lit...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2024.1474490/full |
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| author | Saulius Taroza Helene Plamondon Aurelija Podlipskyte Nijole Kazukauskiene Nicolas Francisco Narvaez Linares Marilou Poitras Julius Burkauskas Narseta Mickuviene |
| author_facet | Saulius Taroza Helene Plamondon Aurelija Podlipskyte Nijole Kazukauskiene Nicolas Francisco Narvaez Linares Marilou Poitras Julius Burkauskas Narseta Mickuviene |
| author_sort | Saulius Taroza |
| collection | DOAJ |
| description | AimThis study intended to explore associations of reverse triiodothyronine (rT3) with emotional disturbances and health-related quality of life (HRQoL) after experiencing acute ischemic stroke (AIS).Materials and methodsSerum samples from individuals with AIS were collected on admission to three Lithuania stroke centers and investigated for free tetraiodothyronine, free triiodothyronine (fT3), rT3, and thyroid stimulating hormone levels. At discharge, emotional disturbance was evaluated using the Hospital Depression and Anxiety Scale (HADS), and HRQoL using the EQ-5D-5L scale.ResultsAnalyses included 159 individuals (59.7% male and 40.3% female; mean (SD) aged 66.4 [10.3] years), 52.83% of which showed increased rT3 levels upon admission. After adjustment for age, sex, National Institutes of Health Stroke Scale scores, previous stroke, modified Rankin Scale before AIS ≤ 2, and diabetes mellitus, multivariable linear regression revealed negative associations of rT3 with HADS total score (β = −0.163; p = 0.046) and HADS-D subscale score (β = −0.187; p = 0.019). Analyses supported a positive relationship between the fT3 ratio to rT3 with HADS-D score (β = 0.157; p = 0.046) and rT3, rT3 × fT3 product with EQ-5D index score (β = 0.157; p = 0.044 and β = 0.179; p = 0.023, respectively).ConclusionWe found that individuals who experienced AIS and had higher levels of rT3 at hospital admission had less emotional disturbance and better HRQoL when discharged. |
| format | Article |
| id | doaj-art-715b943e8cd7456b8a869bb76700995f |
| institution | Kabale University |
| issn | 1664-2295 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj-art-715b943e8cd7456b8a869bb76700995f2025-01-07T15:41:46ZengFrontiers Media S.A.Frontiers in Neurology1664-22952025-01-011510.3389/fneur.2024.14744901474490Associations of reverse triiodothyronine serum levels with anxiety, depression, and health related quality of life after experiencing acute ischemic strokeSaulius Taroza0Helene Plamondon1Aurelija Podlipskyte2Nijole Kazukauskiene3Nicolas Francisco Narvaez Linares4Marilou Poitras5Julius Burkauskas6Narseta Mickuviene7Laboratory of Behavioral Medicine, Neuroscience Institute, Lithuanian University of Health Sciences, Palanga, LithuaniaBehavioural Neuroscience Group, School of Psychology, University of Ottawa, Ottawa, ON, CanadaLaboratory of Behavioral Medicine, Neuroscience Institute, Lithuanian University of Health Sciences, Palanga, LithuaniaLaboratory of Behavioral Medicine, Neuroscience Institute, Lithuanian University of Health Sciences, Palanga, LithuaniaBehavioural Neuroscience Group, School of Psychology, University of Ottawa, Ottawa, ON, CanadaBehavioural Neuroscience Group, School of Psychology, University of Ottawa, Ottawa, ON, CanadaLaboratory of Behavioral Medicine, Neuroscience Institute, Lithuanian University of Health Sciences, Palanga, LithuaniaLaboratory of Behavioral Medicine, Neuroscience Institute, Lithuanian University of Health Sciences, Palanga, LithuaniaAimThis study intended to explore associations of reverse triiodothyronine (rT3) with emotional disturbances and health-related quality of life (HRQoL) after experiencing acute ischemic stroke (AIS).Materials and methodsSerum samples from individuals with AIS were collected on admission to three Lithuania stroke centers and investigated for free tetraiodothyronine, free triiodothyronine (fT3), rT3, and thyroid stimulating hormone levels. At discharge, emotional disturbance was evaluated using the Hospital Depression and Anxiety Scale (HADS), and HRQoL using the EQ-5D-5L scale.ResultsAnalyses included 159 individuals (59.7% male and 40.3% female; mean (SD) aged 66.4 [10.3] years), 52.83% of which showed increased rT3 levels upon admission. After adjustment for age, sex, National Institutes of Health Stroke Scale scores, previous stroke, modified Rankin Scale before AIS ≤ 2, and diabetes mellitus, multivariable linear regression revealed negative associations of rT3 with HADS total score (β = −0.163; p = 0.046) and HADS-D subscale score (β = −0.187; p = 0.019). Analyses supported a positive relationship between the fT3 ratio to rT3 with HADS-D score (β = 0.157; p = 0.046) and rT3, rT3 × fT3 product with EQ-5D index score (β = 0.157; p = 0.044 and β = 0.179; p = 0.023, respectively).ConclusionWe found that individuals who experienced AIS and had higher levels of rT3 at hospital admission had less emotional disturbance and better HRQoL when discharged.https://www.frontiersin.org/articles/10.3389/fneur.2024.1474490/fullreverse T3strokedepressionanxietyhealth-related quality of life |
| spellingShingle | Saulius Taroza Helene Plamondon Aurelija Podlipskyte Nijole Kazukauskiene Nicolas Francisco Narvaez Linares Marilou Poitras Julius Burkauskas Narseta Mickuviene Associations of reverse triiodothyronine serum levels with anxiety, depression, and health related quality of life after experiencing acute ischemic stroke Frontiers in Neurology reverse T3 stroke depression anxiety health-related quality of life |
| title | Associations of reverse triiodothyronine serum levels with anxiety, depression, and health related quality of life after experiencing acute ischemic stroke |
| title_full | Associations of reverse triiodothyronine serum levels with anxiety, depression, and health related quality of life after experiencing acute ischemic stroke |
| title_fullStr | Associations of reverse triiodothyronine serum levels with anxiety, depression, and health related quality of life after experiencing acute ischemic stroke |
| title_full_unstemmed | Associations of reverse triiodothyronine serum levels with anxiety, depression, and health related quality of life after experiencing acute ischemic stroke |
| title_short | Associations of reverse triiodothyronine serum levels with anxiety, depression, and health related quality of life after experiencing acute ischemic stroke |
| title_sort | associations of reverse triiodothyronine serum levels with anxiety depression and health related quality of life after experiencing acute ischemic stroke |
| topic | reverse T3 stroke depression anxiety health-related quality of life |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2024.1474490/full |
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