Comparison of mediastinoscopy and thoracoscope minimally invasive esophagectomy in the treatment of esophageal cancer: a meta-analysis and system review
Abstract Objective The efficacy and safety of transcervical inflatable mediastinoscopic esophagectomy (TIME) in the treatment of esophageal cancer are unclear. The objective of this meta-analysis was to evaluate the efficacy and safety of TIME treatment for esophageal cancer and to compare it with t...
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2025-01-01
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| Series: | BMC Cancer |
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| Online Access: | https://doi.org/10.1186/s12885-024-13307-1 |
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| author | Jincheng Wang Linxian Zhao Jie Lin Yating Yu Ti Tong Yinghao Zhao |
| author_facet | Jincheng Wang Linxian Zhao Jie Lin Yating Yu Ti Tong Yinghao Zhao |
| author_sort | Jincheng Wang |
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| description | Abstract Objective The efficacy and safety of transcervical inflatable mediastinoscopic esophagectomy (TIME) in the treatment of esophageal cancer are unclear. The objective of this meta-analysis was to evaluate the efficacy and safety of TIME treatment for esophageal cancer and to compare it with thoracoscopic assisted minimally invasive esophagectomy (TAMIE) for the treatment of esophageal cancer. Methods A literature search was performed using PubMed, Embase, and the Cochrane Library to retrieve articles published up to January 2024 to comparatively assess studies of TIME and TAMIE. Meta-analysis was performed using randomized/fixed-effects models and heterogeneity was assessed. Results A total of 819 patients were included in the nine studies herein. Among them, 409 patients with esophageal cancer underwent mediastinoscopy-assisted esophagectomy, and 410 patients with esophageal cancer underwent thoracolaparoscopy-assisted esophagectomy. There was no statistical difference between the TIME and TAMIE groups in intraoperative bleeding, incidence of anastomotic fistula, chylothorax, postoperative bleeding, arrhythmia, postoperative complications and in-hospital mortality. In addition, the operative time in the TIME group, 3-day postoperative induced flux, postoperative hospitalization time, number of lymph node dissection, and incidence of pulmonary complications were smaller than those in the TAMIE group, and the differences were all statistically significant. However, in terms of the incidence of recurrent laryngeal nerve injury (including hoarseness), the TIME group was higher than the TAMIE group. Conclusion TIME is a safe and feasible alternative to TAMIE for the treatment of resectable esophageal cancer, but further randomized studies are needed to better assess the long-term benefits of TIME compared with TAMIE. |
| format | Article |
| id | doaj-art-714915a12efa4f88b31ceae3761d223a |
| institution | Kabale University |
| issn | 1471-2407 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Cancer |
| spelling | doaj-art-714915a12efa4f88b31ceae3761d223a2025-01-12T12:27:32ZengBMCBMC Cancer1471-24072025-01-0125111310.1186/s12885-024-13307-1Comparison of mediastinoscopy and thoracoscope minimally invasive esophagectomy in the treatment of esophageal cancer: a meta-analysis and system reviewJincheng Wang0Linxian Zhao1Jie Lin2Yating Yu3Ti Tong4Yinghao Zhao5Department of Thoracic Surgery, the Second Hospital of Jilin UniversityDepartment of General Surgery, The Second Hospital of Jilin UniversityDepartment of Hepatobiliary and Pancreatic Surgery, the Second Hospital of Jilin UniversityDepartment of Thoracic Surgery, the Second Hospital of Jilin UniversityDepartment of Thoracic Surgery, the Second Hospital of Jilin UniversityDepartment of Thoracic Surgery, the Second Hospital of Jilin UniversityAbstract Objective The efficacy and safety of transcervical inflatable mediastinoscopic esophagectomy (TIME) in the treatment of esophageal cancer are unclear. The objective of this meta-analysis was to evaluate the efficacy and safety of TIME treatment for esophageal cancer and to compare it with thoracoscopic assisted minimally invasive esophagectomy (TAMIE) for the treatment of esophageal cancer. Methods A literature search was performed using PubMed, Embase, and the Cochrane Library to retrieve articles published up to January 2024 to comparatively assess studies of TIME and TAMIE. Meta-analysis was performed using randomized/fixed-effects models and heterogeneity was assessed. Results A total of 819 patients were included in the nine studies herein. Among them, 409 patients with esophageal cancer underwent mediastinoscopy-assisted esophagectomy, and 410 patients with esophageal cancer underwent thoracolaparoscopy-assisted esophagectomy. There was no statistical difference between the TIME and TAMIE groups in intraoperative bleeding, incidence of anastomotic fistula, chylothorax, postoperative bleeding, arrhythmia, postoperative complications and in-hospital mortality. In addition, the operative time in the TIME group, 3-day postoperative induced flux, postoperative hospitalization time, number of lymph node dissection, and incidence of pulmonary complications were smaller than those in the TAMIE group, and the differences were all statistically significant. However, in terms of the incidence of recurrent laryngeal nerve injury (including hoarseness), the TIME group was higher than the TAMIE group. Conclusion TIME is a safe and feasible alternative to TAMIE for the treatment of resectable esophageal cancer, but further randomized studies are needed to better assess the long-term benefits of TIME compared with TAMIE.https://doi.org/10.1186/s12885-024-13307-1MediastinoscopyThoracoscopeEsophageal cancerMeta-analysis |
| spellingShingle | Jincheng Wang Linxian Zhao Jie Lin Yating Yu Ti Tong Yinghao Zhao Comparison of mediastinoscopy and thoracoscope minimally invasive esophagectomy in the treatment of esophageal cancer: a meta-analysis and system review BMC Cancer Mediastinoscopy Thoracoscope Esophageal cancer Meta-analysis |
| title | Comparison of mediastinoscopy and thoracoscope minimally invasive esophagectomy in the treatment of esophageal cancer: a meta-analysis and system review |
| title_full | Comparison of mediastinoscopy and thoracoscope minimally invasive esophagectomy in the treatment of esophageal cancer: a meta-analysis and system review |
| title_fullStr | Comparison of mediastinoscopy and thoracoscope minimally invasive esophagectomy in the treatment of esophageal cancer: a meta-analysis and system review |
| title_full_unstemmed | Comparison of mediastinoscopy and thoracoscope minimally invasive esophagectomy in the treatment of esophageal cancer: a meta-analysis and system review |
| title_short | Comparison of mediastinoscopy and thoracoscope minimally invasive esophagectomy in the treatment of esophageal cancer: a meta-analysis and system review |
| title_sort | comparison of mediastinoscopy and thoracoscope minimally invasive esophagectomy in the treatment of esophageal cancer a meta analysis and system review |
| topic | Mediastinoscopy Thoracoscope Esophageal cancer Meta-analysis |
| url | https://doi.org/10.1186/s12885-024-13307-1 |
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