R-loop formation contributes to mTORC1 activation-dependent DNA replication stress induced by p53 deficiency

R-loop formation contributes to mTORC1 activation-dependent DNA replication stress induced by p53 deficiency

DNA replication stress is a significant contributor to spontaneous DNA damage and genome instability. While the impact of p53 deficiency on increasing DNA replication stress is known, the specific molecular mechanism underlying this phenome...

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Bibliographic Details
Main Authors: Li Xiaolei, Yang Cheng, Zhang Xiaohui, Wang Feiyang, Sun Longhua, Zhang Wei, Xu Xinping
Format: Article
Language:English
Published: China Science Publishing & Media Ltd. 2024-11-01
Series:Acta Biochimica et Biophysica Sinica
Subjects:
p53
mTORC1
DNA replication stress
R loops
RNR
Online Access:https://www.sciengine.com/doi/10.3724/abbs.2024188
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