Aging impairs CD8 T cell responses in adoptive T-cell therapy against solid tumors

Aging impairs CD8 T cell responses in adoptive T-cell therapy against solid tumors

Age-associated defects in T cell-mediated immunity can increase the risk of cancers, but how aging influences adoptive T-cell therapy (ACT) for cancers remains unclear. Here, using a mouse model of melanoma, we demonstrate that aging diminishes anti-tumor activity of engineered CD8 T cells expressin...

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Bibliographic Details
Main Authors: Gulfiya Kadyrzhanova, Miho Tamai, Shukla Sarkar, Rajkumar Singh Kalra, Hiroki Ishikawa
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-01-01
Series:Frontiers in Immunology
Subjects:
aging
adoptive T-cell therapy
cancer
CD8 T cells
Epas1
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1484303/full
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