Platycodin D-mediated METTL16 downregulation promotes docetaxel treatment of prostate cancer by regulating ferroptosis

Abstract Background The development of chemotherapy resistance critically constrains the therapeutic efficacy of docetaxel (DTX) in prostate cancer (PCa). Platycodin D (PD) is isolated from the plant Platycodon grandiflorus, and has been found to possess anti-tumor effect. However, whether PD can en...

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Bibliographic Details
Main Authors: Chengwen Sun, Xiaoxiao Sun, Yougan Chen, Yuwei Wu, Congming Xiang, Sheng Wu
Format: Article
Language:English
Published: BMC 2025-07-01
Series:BMC Cancer
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Online Access:https://doi.org/10.1186/s12885-025-14291-w
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