Fluorescence‐Based Detector Design Principles for Low Vapor Pressure Analytes
Abstract Fluorescence‐based sensing is a promising method for detecting trace quantities (vapors) of chemical threats. However, direct detection at standard temperature and pressure of chemicals with low volatilities, such as the salts of illegal drugs, is difficult to achieve. Herein, the developme...
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Wiley-VCH
2025-01-01
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| Series: | Advanced Sensor Research |
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| Online Access: | https://doi.org/10.1002/adsr.202400092 |
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| author | Alex S. Loch Paul L. Burn Paul E. Shaw |
| author_facet | Alex S. Loch Paul L. Burn Paul E. Shaw |
| author_sort | Alex S. Loch |
| collection | DOAJ |
| description | Abstract Fluorescence‐based sensing is a promising method for detecting trace quantities (vapors) of chemical threats. However, direct detection at standard temperature and pressure of chemicals with low volatilities, such as the salts of illegal drugs, is difficult to achieve. Herein, the development of a testing platform designed to maximize the response from fluorescent material detection of low volatility analytes, using the salts of illicit drugs as exemplars, is described. The challenges encountered in detecting low‐volatility analytes are highlighted, and the hardware solutions employed to overcome them are detailed. The testing platform is composed of a swab heating unit, a sensing chamber, and optical components that enable detection of illicit drugs via a fluorescence quenching mechanism. The swab heating unit facilitates volatilization of the analytes, with the shape of the sensing chamber and its fabrication material optimized to maximize the interaction of the analyte with the sensing element, increasing sensitivity. The detection platform is able to detect trace amounts (down to 30 ng) of (±)‐3,4‐methylenedioxyamphetamine hydrochloride (MDA•HCl), along with other common illicit drug salts such as cocaine hydrochloride (cocaine•HCl), fentanyl•HCl, and methamphetamine•HCl (MA•HCl). |
| format | Article |
| id | doaj-art-712683be88924f28bb48fa4ada00c34e |
| institution | Kabale University |
| issn | 2751-1219 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wiley-VCH |
| record_format | Article |
| series | Advanced Sensor Research |
| spelling | doaj-art-712683be88924f28bb48fa4ada00c34e2025-01-09T21:16:46ZengWiley-VCHAdvanced Sensor Research2751-12192025-01-0141n/an/a10.1002/adsr.202400092Fluorescence‐Based Detector Design Principles for Low Vapor Pressure AnalytesAlex S. Loch0Paul L. Burn1Paul E. Shaw2Centre for Organic Photonics & Electronics School of Chemistry and Molecular Biosciences The University of Queensland Queensland 4072 AustraliaCentre for Organic Photonics & Electronics School of Chemistry and Molecular Biosciences The University of Queensland Queensland 4072 AustraliaCentre for Organic Photonics & Electronics School of Chemistry and Molecular Biosciences The University of Queensland Queensland 4072 AustraliaAbstract Fluorescence‐based sensing is a promising method for detecting trace quantities (vapors) of chemical threats. However, direct detection at standard temperature and pressure of chemicals with low volatilities, such as the salts of illegal drugs, is difficult to achieve. Herein, the development of a testing platform designed to maximize the response from fluorescent material detection of low volatility analytes, using the salts of illicit drugs as exemplars, is described. The challenges encountered in detecting low‐volatility analytes are highlighted, and the hardware solutions employed to overcome them are detailed. The testing platform is composed of a swab heating unit, a sensing chamber, and optical components that enable detection of illicit drugs via a fluorescence quenching mechanism. The swab heating unit facilitates volatilization of the analytes, with the shape of the sensing chamber and its fabrication material optimized to maximize the interaction of the analyte with the sensing element, increasing sensitivity. The detection platform is able to detect trace amounts (down to 30 ng) of (±)‐3,4‐methylenedioxyamphetamine hydrochloride (MDA•HCl), along with other common illicit drug salts such as cocaine hydrochloride (cocaine•HCl), fentanyl•HCl, and methamphetamine•HCl (MA•HCl).https://doi.org/10.1002/adsr.202400092devicefluorescenceillicit drugssaltssensing |
| spellingShingle | Alex S. Loch Paul L. Burn Paul E. Shaw Fluorescence‐Based Detector Design Principles for Low Vapor Pressure Analytes Advanced Sensor Research device fluorescence illicit drugs salts sensing |
| title | Fluorescence‐Based Detector Design Principles for Low Vapor Pressure Analytes |
| title_full | Fluorescence‐Based Detector Design Principles for Low Vapor Pressure Analytes |
| title_fullStr | Fluorescence‐Based Detector Design Principles for Low Vapor Pressure Analytes |
| title_full_unstemmed | Fluorescence‐Based Detector Design Principles for Low Vapor Pressure Analytes |
| title_short | Fluorescence‐Based Detector Design Principles for Low Vapor Pressure Analytes |
| title_sort | fluorescence based detector design principles for low vapor pressure analytes |
| topic | device fluorescence illicit drugs salts sensing |
| url | https://doi.org/10.1002/adsr.202400092 |
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