Outcomes and associated factors of cervical human papillomavirus infection among 608 women in Shenzhen, China, 2018–2023
ObjectiveThis study aimed to uncover the patterns of Human papillomavirus (HPV) infection outcomes in women and assess the risk factors that may affect these outcomes.MethodsA retrospective study was conducted on 608 women who tested positive for HPV-DNA during their initial visit to the outpatient...
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Frontiers Media S.A.
2025-01-01
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fpubh.2024.1523839/full |
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| author | Zhenghan Lv Xuesen He Zhiju Li Yue Yuan Xinyi Zhou Changqing Tu Yinqi Yang Yanshan Huang Lili Yin Huihui Chen Yanling Tao Yanling Tao |
| author_facet | Zhenghan Lv Xuesen He Zhiju Li Yue Yuan Xinyi Zhou Changqing Tu Yinqi Yang Yanshan Huang Lili Yin Huihui Chen Yanling Tao Yanling Tao |
| author_sort | Zhenghan Lv |
| collection | DOAJ |
| description | ObjectiveThis study aimed to uncover the patterns of Human papillomavirus (HPV) infection outcomes in women and assess the risk factors that may affect these outcomes.MethodsA retrospective study was conducted on 608 women who tested positive for HPV-DNA during their initial visit to the outpatient department of Shenzhen Longgang Central Hospital from 2018 to 2023 and who had subsequent HPV-DNA testing as part of their post-visit monitoring. The monitoring intervals were every 6 months. The rank sum test was used to analyze ranked data. The Kaplan–Meier method was used to analyze the turning negative time. Univariate analysis was performed using the log-rank test, and multivariate analysis was performed using the Cox model to analyze independent risk factors.ResultsThe results showed that the median age was 40.00 years (interquartile 33.00–47.00 years), the total conversion rate of the HPV-negative patients was 38.98%, and the median conversion time of the HPV-negative patients was 8.95 months (interquartile 4.20–16.175 months). Age, infection status and type of health insurance were significantly correlated with HPV outcome (p < 0.05).ConclusionAmong women infected with HPV, the overall rate of negative HPV infection was 38.93%, and the duration of negative conversion was 8.95 months. The study revealed that age, HPV infection status, and type of medical insurance are independent predictors of the persistence of negative HPV test outcomes. |
| format | Article |
| id | doaj-art-70f72ab177db49e8b4b89eee5de83e23 |
| institution | Kabale University |
| issn | 2296-2565 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Public Health |
| spelling | doaj-art-70f72ab177db49e8b4b89eee5de83e232025-01-14T06:10:37ZengFrontiers Media S.A.Frontiers in Public Health2296-25652025-01-011210.3389/fpubh.2024.15238391523839Outcomes and associated factors of cervical human papillomavirus infection among 608 women in Shenzhen, China, 2018–2023Zhenghan Lv0Xuesen He1Zhiju Li2Yue Yuan3Xinyi Zhou4Changqing Tu5Yinqi Yang6Yanshan Huang7Lili Yin8Huihui Chen9Yanling Tao10Yanling Tao11Clinical Medical College of Shenzhen, Guangzhou University of Chinese Medicine, Shenzhen, ChinaDepartment of Preventive and Health Care, Longgang District Central Hospital of Shenzhen, Shenzhen, ChinaDepartment of Preventive and Health Care, Longgang District Central Hospital of Shenzhen, Shenzhen, ChinaDepartment of Preventive and Health Care, Longgang District Central Hospital of Shenzhen, Shenzhen, ChinaDepartment of Preventive and Health Care, Longgang District Central Hospital of Shenzhen, Shenzhen, ChinaDepartment of Preventive and Health Care, Longgang District Central Hospital of Shenzhen, Shenzhen, ChinaDepartment of Preventive and Health Care, Longgang District Central Hospital of Shenzhen, Shenzhen, ChinaDepartment of Preventive and Health Care, Longgang District Central Hospital of Shenzhen, Shenzhen, ChinaClinical Medical College of Shenzhen, Guangzhou University of Chinese Medicine, Shenzhen, ChinaClinical Medical College of Shenzhen, Guangzhou University of Chinese Medicine, Shenzhen, ChinaClinical Medical College of Shenzhen, Guangzhou University of Chinese Medicine, Shenzhen, ChinaLonggang District Central Hospital of Shenzhen, Shenzhen, ChinaObjectiveThis study aimed to uncover the patterns of Human papillomavirus (HPV) infection outcomes in women and assess the risk factors that may affect these outcomes.MethodsA retrospective study was conducted on 608 women who tested positive for HPV-DNA during their initial visit to the outpatient department of Shenzhen Longgang Central Hospital from 2018 to 2023 and who had subsequent HPV-DNA testing as part of their post-visit monitoring. The monitoring intervals were every 6 months. The rank sum test was used to analyze ranked data. The Kaplan–Meier method was used to analyze the turning negative time. Univariate analysis was performed using the log-rank test, and multivariate analysis was performed using the Cox model to analyze independent risk factors.ResultsThe results showed that the median age was 40.00 years (interquartile 33.00–47.00 years), the total conversion rate of the HPV-negative patients was 38.98%, and the median conversion time of the HPV-negative patients was 8.95 months (interquartile 4.20–16.175 months). Age, infection status and type of health insurance were significantly correlated with HPV outcome (p < 0.05).ConclusionAmong women infected with HPV, the overall rate of negative HPV infection was 38.93%, and the duration of negative conversion was 8.95 months. The study revealed that age, HPV infection status, and type of medical insurance are independent predictors of the persistence of negative HPV test outcomes.https://www.frontiersin.org/articles/10.3389/fpubh.2024.1523839/fullhuman papillomavirusoutcomeprognosisclearance ratecervical lesionsnegative conversion |
| spellingShingle | Zhenghan Lv Xuesen He Zhiju Li Yue Yuan Xinyi Zhou Changqing Tu Yinqi Yang Yanshan Huang Lili Yin Huihui Chen Yanling Tao Yanling Tao Outcomes and associated factors of cervical human papillomavirus infection among 608 women in Shenzhen, China, 2018–2023 Frontiers in Public Health human papillomavirus outcome prognosis clearance rate cervical lesions negative conversion |
| title | Outcomes and associated factors of cervical human papillomavirus infection among 608 women in Shenzhen, China, 2018–2023 |
| title_full | Outcomes and associated factors of cervical human papillomavirus infection among 608 women in Shenzhen, China, 2018–2023 |
| title_fullStr | Outcomes and associated factors of cervical human papillomavirus infection among 608 women in Shenzhen, China, 2018–2023 |
| title_full_unstemmed | Outcomes and associated factors of cervical human papillomavirus infection among 608 women in Shenzhen, China, 2018–2023 |
| title_short | Outcomes and associated factors of cervical human papillomavirus infection among 608 women in Shenzhen, China, 2018–2023 |
| title_sort | outcomes and associated factors of cervical human papillomavirus infection among 608 women in shenzhen china 2018 2023 |
| topic | human papillomavirus outcome prognosis clearance rate cervical lesions negative conversion |
| url | https://www.frontiersin.org/articles/10.3389/fpubh.2024.1523839/full |
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